U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

del(5q31)

MedGen UID:
1771441
•Concept ID:
C5419218
•
Cell or Molecular Dysfunction
Synonyms: 5q Deletion Including 5q31 Deletion; 5q31 Deletion; Chromosome 5q31 Deletion; Loss of 5q31; Loss of Chromosome 5q Including 5q31

Definition

A cytogenetic abnormality that refers to any loss of genetic material from the long arm of chromosome 5 that includes the band at 5q31. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVdel(5q31)

Professional guidelines

PubMed

Systematic screening at diagnosis of -5/del(5)(q31), -7, or chromosome 8 aneuploidy by interphase fluorescence in situ hybridization in 110 acute myelocytic leukemia and high-risk myelodysplastic syndrome patients: concordances and discrepancies with conventional cytogenetics.
Beyer V, Castagné C, Mühlematter D, Parlier V, Gmür J, Hess U, Kovacsovics T, Meyer-Monard S, Tichelli A, Tobler A, Jacky E, Schanz U, Bargetzi M, Hagemeijer A, de Witte T, van Melle G, Jotterand M
Cancer Genet Cytogenet 2004 Jul 1;152(1):29-41. doi: 10.1016/j.cancergencyto.2003.10.005. PMID: 15193439

Recent clinical studies

Etiology

Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.
Möllgård L, Saft L, Treppendahl MB, Dybedal I, Nørgaard JM, Astermark J, Ejerblad E, Garelius H, Dufva IH, Jansson M, Jädersten M, Kjeldsen L, Linder O, Nilsson L, Vestergaard H, Porwit A, Grønbæk K, Hellström-Lindberg E
Haematologica 2011 Jul;96(7):963-71. doi: 10.3324/haematol.2010.039669. PMID: 21719884Free PMC Article

Diagnosis

Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.
Möllgård L, Saft L, Treppendahl MB, Dybedal I, Nørgaard JM, Astermark J, Ejerblad E, Garelius H, Dufva IH, Jansson M, Jädersten M, Kjeldsen L, Linder O, Nilsson L, Vestergaard H, Porwit A, Grønbæk K, Hellström-Lindberg E
Haematologica 2011 Jul;96(7):963-71. doi: 10.3324/haematol.2010.039669. PMID: 21719884Free PMC Article
Partial chromosome deletion: a new trisomy rescue mechanism?
Vialard F, Molina-Gomes D, Quarello E, Leroy B, Ville Y, Selva J
Fetal Diagn Ther 2009;25(1):111-4. Epub 2009 Feb 25 doi: 10.1159/000203400. PMID: 19246929
Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroup.
Giagounidis AA, Germing U, Strupp C, Hildebrandt B, Heinsch M, Aul C
Ann Hematol 2005 Sep;84(9):569-71. Epub 2005 May 13 doi: 10.1007/s00277-005-1054-0. PMID: 15891887

Therapy

Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.
Möllgård L, Saft L, Treppendahl MB, Dybedal I, Nørgaard JM, Astermark J, Ejerblad E, Garelius H, Dufva IH, Jansson M, Jädersten M, Kjeldsen L, Linder O, Nilsson L, Vestergaard H, Porwit A, Grønbæk K, Hellström-Lindberg E
Haematologica 2011 Jul;96(7):963-71. doi: 10.3324/haematol.2010.039669. PMID: 21719884Free PMC Article
Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroup.
Giagounidis AA, Germing U, Strupp C, Hildebrandt B, Heinsch M, Aul C
Ann Hematol 2005 Sep;84(9):569-71. Epub 2005 May 13 doi: 10.1007/s00277-005-1054-0. PMID: 15891887

Prognosis

Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.
Möllgård L, Saft L, Treppendahl MB, Dybedal I, Nørgaard JM, Astermark J, Ejerblad E, Garelius H, Dufva IH, Jansson M, Jädersten M, Kjeldsen L, Linder O, Nilsson L, Vestergaard H, Porwit A, Grønbæk K, Hellström-Lindberg E
Haematologica 2011 Jul;96(7):963-71. doi: 10.3324/haematol.2010.039669. PMID: 21719884Free PMC Article
Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroup.
Giagounidis AA, Germing U, Strupp C, Hildebrandt B, Heinsch M, Aul C
Ann Hematol 2005 Sep;84(9):569-71. Epub 2005 May 13 doi: 10.1007/s00277-005-1054-0. PMID: 15891887

Clinical prediction guides

Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.
Möllgård L, Saft L, Treppendahl MB, Dybedal I, Nørgaard JM, Astermark J, Ejerblad E, Garelius H, Dufva IH, Jansson M, Jädersten M, Kjeldsen L, Linder O, Nilsson L, Vestergaard H, Porwit A, Grønbæk K, Hellström-Lindberg E
Haematologica 2011 Jul;96(7):963-71. doi: 10.3324/haematol.2010.039669. PMID: 21719884Free PMC Article
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.
Chen TH, Kambal A, Krysiak K, Walshauser MA, Raju G, Tibbitts JF, Walter MJ
Blood 2011 Feb 3;117(5):1530-9. Epub 2010 Dec 1 doi: 10.1182/blood-2010-06-293167. PMID: 21123823Free PMC Article
Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH).
Escobar PA, Smith MT, Vasishta A, Hubbard AE, Zhang L
Mutagenesis 2007 Sep;22(5):321-7. Epub 2007 Jun 16 doi: 10.1093/mutage/gem020. PMID: 17575318

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...