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Anti-citrullinated protein antibody positivity

MedGen UID:
1767562
•Concept ID:
C5421563
•
Laboratory or Test Result
HPO: HP:0033034

Definition

The presence autoantibodies in the serum that react do different citrullinated antigens, including filaggrin, fibrinogen, vimentin and collagen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-citrullinated protein antibody positivity

Conditions with this feature

Rheumatoid arthritis
MedGen UID:
2078
•Concept ID:
C0003873
•
Disease or Syndrome
Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component.
See: Condition Record
Rheumatoid arthritis

Professional guidelines

PubMed

Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma.
Borgers JSW, van Wesemael TJ, Gelderman KA, Rispens T, Verdegaal EME, Moes DJAR, Korse CM, Kapiteijn E, Welters MJP, van der Burg SH, van Houdt WJ, van Thienen JV, Haanen JBAG, van der Woude D
J Immunother Cancer 2024 Jun 30;12(6) doi: 10.1136/jitc-2024-009215. PMID: 38945553Free PMC Article
Elderly-Onset Rheumatoid Arthritis: Characteristics and Treatment Options.
Pavlov-Dolijanovic S, Bogojevic M, Nozica-Radulovic T, Radunovic G, Mujovic N
Medicina (Kaunas) 2023 Oct 23;59(10) doi: 10.3390/medicina59101878. PMID: 37893596Free PMC Article
Measuring ACPA in the general population or primary care: is it useful?
Finckh A, Courvoisier D, Lamacchia C; Recherche clinique en rhumatismes inflammatoires
RMD Open 2020 Feb;6(1) doi: 10.1136/rmdopen-2019-001085. PMID: 32079664Free PMC Article

Recent systematic reviews

Baseline patient reported outcomes are more consistent predictors of long-term functional disability than laboratory, imaging or joint count data in patients with early inflammatory arthritis: A systematic review.
Gwinnutt JM, Sharp CA, Symmons DPM, Lunt M, Verstappen SMM
Semin Arthritis Rheum 2018 Dec;48(3):384-398. Epub 2018 Mar 15 doi: 10.1016/j.semarthrit.2018.03.004. PMID: 29680162Free PMC Article

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