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Biceps hyperreflexia

MedGen UID:
1764189
•Concept ID:
C5421682
•
Finding
HPO: HP:0033205

Definition

Increased intensity of the biceps reflex. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBiceps hyperreflexia

Conditions with this feature

Hereditary spastic paraplegia 18
MedGen UID:
442343
•Concept ID:
C2749936
•
Disease or Syndrome
Spastic paraplegia-18B (SPG18B) is a severe autosomal recessive neurologic disorder characterized by onset in early childhood of progressive spastic paraplegia resulting in motor disability. Most affected individuals have severe psychomotor retardation. Some may develop significant joint contractures (summary by Alazami et al., 2011 and Yildirim et al., 2011).
See: Condition Record
Hereditary spastic paraplegia 18

Professional guidelines

PubMed

Clinical use of polysynaptic flexion reflexes in the management of spasticity with intrathecal baclofen.
Parise M, García-Larrea L, Mertens P, Sindou M, Mauguière F
Electroencephalogr Clin Neurophysiol 1997 Apr;105(2):141-8. doi: 10.1016/s0924-980x(96)96555-8. PMID: 9152209

Recent clinical studies

Etiology

Nociceptive flexion reflex in small fibers neuropathy and pain assessments†.
Ser MH, Yılmaz B, Sulu C, Gönen MS, Gunduz A
Pain Med 2023 Oct 3;24(10):1161-1168. doi: 10.1093/pm/pnad077. PMID: 37294833
Activation of elbow extensors during passive stretch of flexors in patients with post-stroke spasticity.
Levin MF, Solomon JM, Shah A, Blanchette AK, Feldman AG
Clin Neurophysiol 2018 Oct;129(10):2065-2074. Epub 2018 Jul 24 doi: 10.1016/j.clinph.2018.07.007. PMID: 30077867
Correlation of cord signal change with physical examination findings in patients with cervical myelopathy.
Nemani VM, Kim HJ, Piyaskulkaew C, Nguyen JT, Riew KD
Spine (Phila Pa 1976) 2015 Jan 1;40(1):6-10. doi: 10.1097/BRS.0000000000000659. PMID: 25341986
Enhanced trigemino-cervical-spinal reflex recovery cycle in pain-free migraineurs.
Serrao M, Perrotta A, Bartolo M, Fiermonte G, Pauri F, Rossi P, Parisi L, Pierelli F
Headache 2005 Sep;45(8):1061-8. doi: 10.1111/j.1526-4610.2005.05188.x. PMID: 16109121
Startle responses in hereditary hyperekplexia.
Tijssen MA, Voorkamp LM, Padberg GW, van Dijk JG
Arch Neurol 1997 Apr;54(4):388-93. doi: 10.1001/archneur.1997.00550160034012. PMID: 9109739

Diagnosis

Nociceptive flexion reflex in small fibers neuropathy and pain assessments†.
Ser MH, Yılmaz B, Sulu C, Gönen MS, Gunduz A
Pain Med 2023 Oct 3;24(10):1161-1168. doi: 10.1093/pm/pnad077. PMID: 37294833
Tap-Elicited Clonus of the Biceps and Triceps Brachii.
Nishida Y, Ishiguro T, Yokota T
JAMA Neurol 2022 Feb 1;79(2):194. doi: 10.1001/jamaneurol.2021.4273. PMID: 34807237
Superiority of sonographic evaluation of contracted versus relaxed muscle thickness in motor neuron diseases.
Abraham A, Fainmesser Y, Lovblom LE, Bril V, Drory VE
Clin Neurophysiol 2020 Jul;131(7):1480-1486. Epub 2020 Apr 16 doi: 10.1016/j.clinph.2020.04.003. PMID: 32387966
Stretch reflex excitability in contralateral limbs of stroke survivors is higher than in matched controls.
Afzal T, Chardon MK, Rymer WZ, Suresh NL
J Neuroeng Rehabil 2019 Dec 5;16(1):154. doi: 10.1186/s12984-019-0623-8. PMID: 31806032Free PMC Article
T-wave response in cervical root lesions.
Schott K, Koenig E
Acta Neurol Scand 1991 Oct;84(4):273-6. doi: 10.1111/j.1600-0404.1991.tb04953.x. PMID: 1771998

Therapy

Neurophysiological evidence for muscle tone reduction by intrathecal baclofen at the brainstem level.
Kumru H, Stetkarova I, Schindler C, Vidal J, Kofler M
Clin Neurophysiol 2011 Jun;122(6):1229-37. Epub 2010 Oct 2 doi: 10.1016/j.clinph.2010.09.010. PMID: 20889372
Auditory startle reaction in primary blepharospasm.
Müller J, Rinnerthaler M, Poewe W, Kofler M
Mov Disord 2007 Jan 15;22(2):268-72. doi: 10.1002/mds.21270. PMID: 17149731
Abnormal head nociceptive withdrawal reaction to facial nociceptive stimuli in Parkinson's disease.
Perrotta A, Serrao M, Bartolo M, Valletta L, Locuratolo N, Pujia F, Fattapposta F, Bramanti P, Amabile GA, Pierelli F, Parisi L
Clin Neurophysiol 2005 Sep;116(9):2091-8. doi: 10.1016/j.clinph.2005.05.011. PMID: 16029959
Abnormal perception of the tonic vibration reflex in idiopathic focal dystonia.
Yoneda Y, Rome S, Sagar HJ, Grünewald RA
Eur J Neurol 2000 Sep;7(5):529-33. doi: 10.1046/j.1468-1331.2000.t01-1-00102.x. PMID: 11054138
Idiopathic focal dystonia: a disorder of muscle spindle afferent processing?
Grünewald RA, Yoneda Y, Shipman JM, Sagar HJ
Brain 1997 Dec;120 ( Pt 12):2179-85. doi: 10.1093/brain/120.12.2179. PMID: 9448573

Prognosis

Nociceptive flexion reflex in small fibers neuropathy and pain assessments†.
Ser MH, Yılmaz B, Sulu C, Gönen MS, Gunduz A
Pain Med 2023 Oct 3;24(10):1161-1168. doi: 10.1093/pm/pnad077. PMID: 37294833
Characterization of Differences in the Time Course of Reflex and Voluntary Responses Following Botulinum Toxin Injections in Chronic Stroke Survivors.
Afsharipour B, Chandra S, Li G, Rymer WZ, Suresh NL
IEEE Trans Neural Syst Rehabil Eng 2020 Jul;28(7):1642-1650. doi: 10.1109/TNSRE.2020.2997213. PMID: 32634101
Aging effects of motor prediction on protective balance and startle responses to sudden drop perturbations.
Sanders O, Hsiao HY, Savin DN, Creath RA, Rogers MW
J Biomech 2019 Jun 25;91:23-31. Epub 2019 May 10 doi: 10.1016/j.jbiomech.2019.05.005. PMID: 31128842Free PMC Article
Neurophysiological evidence for muscle tone reduction by intrathecal baclofen at the brainstem level.
Kumru H, Stetkarova I, Schindler C, Vidal J, Kofler M
Clin Neurophysiol 2011 Jun;122(6):1229-37. Epub 2010 Oct 2 doi: 10.1016/j.clinph.2010.09.010. PMID: 20889372
Do associated reactions in the upper limb after stroke contribute to contracture formation?
Ada L, Q'Dwyer N
Clin Rehabil 2001 Apr;15(2):186-94. doi: 10.1191/026921501676635731. PMID: 11330764

Clinical prediction guides

Nociceptive flexion reflex in small fibers neuropathy and pain assessments†.
Ser MH, Yılmaz B, Sulu C, Gönen MS, Gunduz A
Pain Med 2023 Oct 3;24(10):1161-1168. doi: 10.1093/pm/pnad077. PMID: 37294833
Movement perception of the tonic vibration reflex is abnormal in functional limb weakness.
Tinazzi M, Marotta A, Zenorini M, Riello M, Antonini A, Fiorio M
Parkinsonism Relat Disord 2021 Jun;87:1-6. Epub 2021 Apr 20 doi: 10.1016/j.parkreldis.2021.04.011. PMID: 33895678
Superiority of sonographic evaluation of contracted versus relaxed muscle thickness in motor neuron diseases.
Abraham A, Fainmesser Y, Lovblom LE, Bril V, Drory VE
Clin Neurophysiol 2020 Jul;131(7):1480-1486. Epub 2020 Apr 16 doi: 10.1016/j.clinph.2020.04.003. PMID: 32387966
Neurophysiological evidence for muscle tone reduction by intrathecal baclofen at the brainstem level.
Kumru H, Stetkarova I, Schindler C, Vidal J, Kofler M
Clin Neurophysiol 2011 Jun;122(6):1229-37. Epub 2010 Oct 2 doi: 10.1016/j.clinph.2010.09.010. PMID: 20889372
Reflexes from the superficial peroneal nerve during walking in stroke subjects.
Zehr EP, Fujita K, Stein RB
J Neurophysiol 1998 Feb;79(2):848-58. doi: 10.1152/jn.1998.79.2.848. PMID: 9463446

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