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Overt Stroke

MedGen UID:
1754069
•Concept ID:
C5400991
•
Disease or Syndrome
Synonym: Overt Cerebral Infarction

Definition

A cerebral infarction that is evident by new neurological symptoms lasting greater than 24 hours or having an area of diffusion restriction or a T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensity on an MRI of the brain that was consistent with the neurological findings. [from NCI]

Professional guidelines

PubMed

Primary and Secondary Stroke Prevention in Children With Sickle Cell Disease.
Mack AK, Thompson AA
J Pediatr Health Care 2017 Mar-Apr;31(2):145-154. Epub 2016 Jul 14 doi: 10.1016/j.pedhc.2016.06.005. PMID: 27423528
Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
Wang WC, Dwan K
Cochrane Database Syst Rev 2013 Nov 14;(11):CD003146. doi: 10.1002/14651858.CD003146.pub2. PMID: 24226646Free PMC Article
Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management.
Black SE
J R Coll Physicians Edinb 2011 Mar;41(1):49-56. doi: 10.4997/JRCPE.2011.121. PMID: 21365068

Recent clinical studies

Etiology

Distribution of Silent Cerebral Infarcts in Adults With Sickle Cell Disease.
Jones RS, Ford AL, Donahue MJ, Fellah S, Davis LT, Pruthi S, Balamurugan C, Cohen R, Davis S, Debaun MR, Kassim AA, Rodeghier M, Jordan LC
Neurology 2024 May;102(10):e209247. Epub 2024 Apr 29 doi: 10.1212/WNL.0000000000209247. PMID: 38684044Free PMC Article
Sickle Cell Disease and Stroke.
Hirtz D, Kirkham FJ
Pediatr Neurol 2019 Jun;95:34-41. Epub 2019 Feb 27 doi: 10.1016/j.pediatrneurol.2019.02.018. PMID: 30948147
Neuroprotective measures throughout the TAVI pathway.
Shiyovich A, Kornowski R
Minerva Cardioangiol 2019 Feb;67(1):39-56. Epub 2018 Jul 17 doi: 10.23736/S0026-4725.18.04763-1. PMID: 30014679
Dementia and Atrial Fibrillation: Pathophysiological Mechanisms and Therapeutic Implications.
Chopard R, Piazza G, Gale SA, Campia U, Albertsen IE, Kim J, Goldhaber SZ
Am J Med 2018 Dec;131(12):1408-1417. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.06.035. PMID: 30076825
Sickle cell disease.
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Diagnosis

Silent cerebral infarction during immune TTP remission: prevalence, predictors, and impact on cognition.
Chaturvedi S, Yu J, Brown J, Wei A, Selvakumar S, Gerber GF, Moliterno AR, Streiff MB, Kraus P, Logue CM, Yui JC, Naik RP, Latif H, Lanzkron SM, Braunstein EM, Brodsky RA, Gottesman RF, Lin DD
Blood 2023 Jul 27;142(4):325-335. doi: 10.1182/blood.2023019663. PMID: 37216688Free PMC Article
Sickle Cell Disease and Stroke.
Hirtz D, Kirkham FJ
Pediatr Neurol 2019 Jun;95:34-41. Epub 2019 Feb 27 doi: 10.1016/j.pediatrneurol.2019.02.018. PMID: 30948147
Neuroprotective measures throughout the TAVI pathway.
Shiyovich A, Kornowski R
Minerva Cardioangiol 2019 Feb;67(1):39-56. Epub 2018 Jul 17 doi: 10.23736/S0026-4725.18.04763-1. PMID: 30014679
Silent brain infarction--a review of recent observations.
Kovács KR, Czuriga D, Bereczki D, Bornstein NM, Csiba L
Int J Stroke 2013 Jul;8(5):334-47. Epub 2012 Aug 1 doi: 10.1111/j.1747-4949.2012.00851.x. PMID: 22863197
Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management.
Black SE
J R Coll Physicians Edinb 2011 Mar;41(1):49-56. doi: 10.4997/JRCPE.2011.121. PMID: 21365068

Therapy

Molecular and environmental contributors to neurological complications in sickle cell disease.
Karkoska KA, Gollamudi J, Hyacinth HI
Exp Biol Med (Maywood) 2023 Aug;248(15):1319-1332. Epub 2023 Sep 9 doi: 10.1177/15353702231187646. PMID: 37688519Free PMC Article
Stroke in sickle cell disease and the promise of recent disease modifying agents.
Runge A, Brazel D, Pakbaz Z
J Neurol Sci 2022 Nov 15;442:120412. Epub 2022 Sep 9 doi: 10.1016/j.jns.2022.120412. PMID: 36150233
Sickle Cell Disease and Stroke.
Hirtz D, Kirkham FJ
Pediatr Neurol 2019 Jun;95:34-41. Epub 2019 Feb 27 doi: 10.1016/j.pediatrneurol.2019.02.018. PMID: 30948147
Neuroprotective measures throughout the TAVI pathway.
Shiyovich A, Kornowski R
Minerva Cardioangiol 2019 Feb;67(1):39-56. Epub 2018 Jul 17 doi: 10.23736/S0026-4725.18.04763-1. PMID: 30014679
Dementia and Atrial Fibrillation: Pathophysiological Mechanisms and Therapeutic Implications.
Chopard R, Piazza G, Gale SA, Campia U, Albertsen IE, Kim J, Goldhaber SZ
Am J Med 2018 Dec;131(12):1408-1417. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.06.035. PMID: 30076825

Prognosis

Distribution of Silent Cerebral Infarcts in Adults With Sickle Cell Disease.
Jones RS, Ford AL, Donahue MJ, Fellah S, Davis LT, Pruthi S, Balamurugan C, Cohen R, Davis S, Debaun MR, Kassim AA, Rodeghier M, Jordan LC
Neurology 2024 May;102(10):e209247. Epub 2024 Apr 29 doi: 10.1212/WNL.0000000000209247. PMID: 38684044Free PMC Article
Silent cerebral infarction during immune TTP remission: prevalence, predictors, and impact on cognition.
Chaturvedi S, Yu J, Brown J, Wei A, Selvakumar S, Gerber GF, Moliterno AR, Streiff MB, Kraus P, Logue CM, Yui JC, Naik RP, Latif H, Lanzkron SM, Braunstein EM, Brodsky RA, Gottesman RF, Lin DD
Blood 2023 Jul 27;142(4):325-335. doi: 10.1182/blood.2023019663. PMID: 37216688Free PMC Article
The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease.
Ramos K, Guilliams KP, Fields ME
Hematol Oncol Clin North Am 2022 Dec;36(6):1167-1186. doi: 10.1016/j.hoc.2022.07.011. PMID: 36400537Free PMC Article
Genetic modifiers of the beta-haemoglobinopathies.
Thein SL
Br J Haematol 2008 May;141(3):357-66. doi: 10.1111/j.1365-2141.2008.07084.x. PMID: 18410570
Sickle cell disease.
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Clinical prediction guides

Distribution of Silent Cerebral Infarcts in Adults With Sickle Cell Disease.
Jones RS, Ford AL, Donahue MJ, Fellah S, Davis LT, Pruthi S, Balamurugan C, Cohen R, Davis S, Debaun MR, Kassim AA, Rodeghier M, Jordan LC
Neurology 2024 May;102(10):e209247. Epub 2024 Apr 29 doi: 10.1212/WNL.0000000000209247. PMID: 38684044Free PMC Article
Silent cerebral infarction during immune TTP remission: prevalence, predictors, and impact on cognition.
Chaturvedi S, Yu J, Brown J, Wei A, Selvakumar S, Gerber GF, Moliterno AR, Streiff MB, Kraus P, Logue CM, Yui JC, Naik RP, Latif H, Lanzkron SM, Braunstein EM, Brodsky RA, Gottesman RF, Lin DD
Blood 2023 Jul 27;142(4):325-335. doi: 10.1182/blood.2023019663. PMID: 37216688Free PMC Article
The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease.
Ramos K, Guilliams KP, Fields ME
Hematol Oncol Clin North Am 2022 Dec;36(6):1167-1186. doi: 10.1016/j.hoc.2022.07.011. PMID: 36400537Free PMC Article
Genetic modifiers of the beta-haemoglobinopathies.
Thein SL
Br J Haematol 2008 May;141(3):357-66. doi: 10.1111/j.1365-2141.2008.07084.x. PMID: 18410570
Sickle cell disease.
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Recent systematic reviews

Burden of central nervous system complications in sickle cell disease: A systematic review and meta-analysis.
Lee S, Lucas S, Proudman D, Nellesen D, Paulose J, Sheehan VA
Pediatr Blood Cancer 2022 Apr;69(4):e29493. Epub 2022 Jan 17 doi: 10.1002/pbc.29493. PMID: 35038214
A systematic review of the literature for severity predictors in children with sickle cell anemia.
Meier ER, Fasano RM, Levett PR
Blood Cells Mol Dis 2017 Jun;65:86-94. Epub 2017 Feb 2 doi: 10.1016/j.bcmd.2017.01.014. PMID: 28185829
Neurological Outcomes With Embolic Protection Devices in Patients Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Giustino G, Mehran R, Veltkamp R, Faggioni M, Baber U, Dangas GD
JACC Cardiovasc Interv 2016 Oct 24;9(20):2124-2133. doi: 10.1016/j.jcin.2016.07.024. PMID: 27765306
Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.
Lance EI, Casella JF, Everett AD, Barron-Casella E
Proteomics Clin Appl 2014 Dec;8(11-12):813-27. Epub 2014 Nov 6 doi: 10.1002/prca.201400069. PMID: 25290359Free PMC Article
Silent brain infarcts: a systematic review.
Vermeer SE, Longstreth WT Jr, Koudstaal PJ
Lancet Neurol 2007 Jul;6(7):611-9. doi: 10.1016/S1474-4422(07)70170-9. PMID: 17582361

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