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Unresectable Vulvar Squamous Cell Carcinoma

MedGen UID:
1748386
•Concept ID:
C5420647
•
Neoplastic Process

Definition

Vulvar squamous cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Vulvar Squamous Cell Carcinoma

Professional guidelines

PubMed

Management of inguinal lymph nodes in locally advanced, surgically unresectable, squamous cell carcinoma of the vulva.
Swift BE, Khoja L, Matthews J, Croke J, Laframboise S, Leung E, Gien LT
Gynecol Oncol 2024 Aug;187:46-50. Epub 2024 May 8 doi: 10.1016/j.ygyno.2024.04.025. PMID: 38723339

Recent clinical studies

Etiology

NOTCH1 and PIK3CA mutation are related to HPV-associated vulvar squamous cell carcinoma.
Choschzick M, Stergiou C, Gut A, Zoche M, Ross JS, Moch H
Pathol Res Pract 2023 Nov;251:154877. Epub 2023 Oct 7 doi: 10.1016/j.prp.2023.154877. PMID: 37839360
High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Definitive Chemoradiotherapy for Vulvar Cancer.
Natesan D, Susko M, Havrilesky L, Chino J
Int J Gynecol Cancer 2016 Nov;26(9):1699-1705. doi: 10.1097/IGC.0000000000000811. PMID: 27575629
Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article

Diagnosis

Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Basal cell carcinoma of the vulva: a case series.
Mulvany NJ, Rayoo M, Allen DG
Pathology 2012 Oct;44(6):528-33. doi: 10.1097/PAT.0b013e328357a001. PMID: 22935972
Comparison of outcome measures in patients with advanced squamous cell carcinoma of the vulva treated with surgery or primary chemoradiation.
Landrum LM, Skaggs V, Gould N, Walker JL, McMeekin DS
Gynecol Oncol 2008 Mar;108(3):584-90. Epub 2007 Dec 26 doi: 10.1016/j.ygyno.2007.11.010. PMID: 18155755
Groin recurrence in patients with vulvar cancer with negative nodes on superficial inguinal lymphadenectomy.
Gordinier ME, Malpica A, Burke TW, Bodurka DC, Wolf JK, Jhingran A, Ramirez PT, Levenback C
Gynecol Oncol 2003 Sep;90(3):625-8. doi: 10.1016/s0090-8258(03)00374-3. PMID: 13678736

Therapy

A phase 2 study of combined chemo-immunotherapy with cisplatin-pembrolizumab and radiation for unresectable vulvar squamous cell carcinoma.
Yeku O, Russo AL, Lee H, Spriggs D
J Transl Med 2020 Sep 14;18(1):350. doi: 10.1186/s12967-020-02523-5. PMID: 32928237Free PMC Article
High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article
Prolonged continuous infusion cisplatin and 5-fluorouracil with radiation for locally advanced carcinoma of the vulva.
Eifel PJ, Morris M, Burke TW, Levenback C, Gershenson DM
Gynecol Oncol 1995 Oct;59(1):51-6. doi: 10.1006/gyno.1995.1267. PMID: 7557615
Management of locally advanced squamous cell carcinoma of the vulva.
Hoffman MS, Greenberg H, Roberts WS, Fiorica JV, LaPolla JP, Barton DP, Cavanagh D
J Gynecol Surg 1991 Fall;7(3):175-82. doi: 10.1089/gyn.1991.7.175. PMID: 10149781

Prognosis

High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Comparison of outcome measures in patients with advanced squamous cell carcinoma of the vulva treated with surgery or primary chemoradiation.
Landrum LM, Skaggs V, Gould N, Walker JL, McMeekin DS
Gynecol Oncol 2008 Mar;108(3):584-90. Epub 2007 Dec 26 doi: 10.1016/j.ygyno.2007.11.010. PMID: 18155755
Carcinoma of the vulva.
Stehman FB, Look KY
Obstet Gynecol 2006 Mar;107(3):719-33. doi: 10.1097/01.AOG.0000202404.55215.72. PMID: 16507947
Management of locally advanced squamous cell carcinoma of the vulva.
Hoffman MS, Greenberg H, Roberts WS, Fiorica JV, LaPolla JP, Barton DP, Cavanagh D
J Gynecol Surg 1991 Fall;7(3):175-82. doi: 10.1089/gyn.1991.7.175. PMID: 10149781

Clinical prediction guides

High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article
Comparison of outcome measures in patients with advanced squamous cell carcinoma of the vulva treated with surgery or primary chemoradiation.
Landrum LM, Skaggs V, Gould N, Walker JL, McMeekin DS
Gynecol Oncol 2008 Mar;108(3):584-90. Epub 2007 Dec 26 doi: 10.1016/j.ygyno.2007.11.010. PMID: 18155755
Synchronous radiation and cytotoxic chemotherapy for locally advanced or recurrent squamous cancer of the vulva.
Russell AH, Mesic JB, Scudder SA, Rosenberg PJ, Smith LH, Kinney WK, Townsend DE, Trelford JD, Taylor MH, Zukowski CL
Gynecol Oncol 1992 Oct;47(1):14-20. doi: 10.1016/0090-8258(92)90068-t. PMID: 1427394

Recent systematic reviews

Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article

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