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Symptomatic COVID-19 Infection Laboratory-Confirmed

MedGen UID:
1747182
Concept ID:
C5419162
Disease or Syndrome
Synonyms: COVID-19 Symptomatic Laboratory-Confirmed; Symptomatic SARS-CoV-2 Infection Laboratory-Confirmed

Definition

An infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is symptomatic at the time of testing. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSymptomatic COVID-19 Infection Laboratory-Confirmed

Professional guidelines

PubMed

Tomita T, Miyazawa S, Sonoyama T
Medicine (Baltimore) 2024 Jul 26;103(30):e39080. doi: 10.1097/MD.0000000000039080. PMID: 39058834Free PMC Article
Sekkarie A, Woodruff R, Whitaker M, Kramer MR, Zapata LB, Ellington SR, Meaney-Delman DM, Pham H, Patel K, Taylor CA, Chai SJ, Kawasaki B, Meek J, Openo KP, Weigel A, Leegwater L, Como-Sabetti K, Ropp SL, Muse A, Bennett NM, Billing LM, Sutton M, Talbot HK, Hill M, Havers FP; COVID-19-Associated Hospitalization Surveillance Network COVID-NET Surveillance Team
Am J Obstet Gynecol MFM 2022 Nov;4(6):100715. Epub 2022 Aug 12 doi: 10.1016/j.ajogmf.2022.100715. PMID: 35970493Free PMC Article
Yeh R, Elsakka A, Wray R, Johnston RP, Gangai NC, Yarmohammadi H, Schoder H, Pandit-Taskar N
Clin Imaging 2021 Dec;80:262-267. Epub 2021 Aug 8 doi: 10.1016/j.clinimag.2021.08.002. PMID: 34418873Free PMC Article

Recent clinical studies

Etiology

Villar J, Soto Conti CP, Gunier RB, Ariff S, Craik R, Cavoretto PI, Rauch S, Gandino S, Nieto R, Winsey A, Menis C, Rodriguez GB, Savasi V, Tug N, Deantoni S, Fabre M, Martinez de Tejada B, Rodriguez-Sibaja MJ, Livio S, Napolitano R, Maiz N, Sobrero H, Peterson A, Deruelle P, Giudice C, Teji JS, Casale RA, Salomon LJ, Prefumo F, Cheikh Ismail L, Gravett MG, Vale M, Hernández V, Sentilhes L, Easter SR, Capelli C, Marler E, Cáceres DM, Albornoz Crespo G, Ernawati E, Lipschuetz M, Takahashi K, Vecchiarelli C, Hubka T, Ikenoue S, Tavchioska G, Bako B, Ayede AI, Eskenazi B, Thornton JG, Bhutta ZA, Kennedy SH, Papageorghiou AT; INTERCOVID-2022 International Consortium
Lancet 2023 Feb 11;401(10375):447-457. Epub 2023 Jan 17 doi: 10.1016/S0140-6736(22)02467-9. PMID: 36669520Free PMC Article
Al Kaabi N, Zhang Y, Xia S, Yang Y, Al Qahtani MM, Abdulrazzaq N, Al Nusair M, Hassany M, Jawad JS, Abdalla J, Hussein SE, Al Mazrouei SK, Al Karam M, Li X, Yang X, Wang W, Lai B, Chen W, Huang S, Wang Q, Yang T, Liu Y, Ma R, Hussain ZM, Khan T, Saifuddin Fasihuddin M, You W, Xie Z, Zhao Y, Jiang Z, Zhao G, Zhang Y, Mahmoud S, ElTantawy I, Xiao P, Koshy A, Zaher WA, Wang H, Duan K, Pan A, Yang X
JAMA 2021 Jul 6;326(1):35-45. doi: 10.1001/jama.2021.8565. PMID: 34037666Free PMC Article
Folegatti PM, Ewer KJ, Aley PK, Angus B, Becker S, Belij-Rammerstorfer S, Bellamy D, Bibi S, Bittaye M, Clutterbuck EA, Dold C, Faust SN, Finn A, Flaxman AL, Hallis B, Heath P, Jenkin D, Lazarus R, Makinson R, Minassian AM, Pollock KM, Ramasamy M, Robinson H, Snape M, Tarrant R, Voysey M, Green C, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group
Lancet 2020 Aug 15;396(10249):467-478. Epub 2020 Jul 20 doi: 10.1016/S0140-6736(20)31604-4. PMID: 32702298Free PMC Article
Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, Skipper CP, Nascene AA, Nicol MR, Abassi M, Engen NW, Cheng MP, LaBar D, Lother SA, MacKenzie LJ, Drobot G, Marten N, Zarychanski R, Kelly LE, Schwartz IS, McDonald EG, Rajasingham R, Lee TC, Hullsiek KH
N Engl J Med 2020 Aug 6;383(6):517-525. Epub 2020 Jun 3 doi: 10.1056/NEJMoa2016638. PMID: 32492293Free PMC Article
Diao B, Wang C, Tan Y, Chen X, Liu Y, Ning L, Chen L, Li M, Liu Y, Wang G, Yuan Z, Feng Z, Zhang Y, Wu Y, Chen Y
Front Immunol 2020;11:827. Epub 2020 May 1 doi: 10.3389/fimmu.2020.00827. PMID: 32425950Free PMC Article

Diagnosis

Feldstein LR, Britton A, Grant L, Wiegand R, Ruffin J, Babu TM, Briggs Hagen M, Burgess JL, Caban-Martinez AJ, Chu HY, Ellingson KD, Englund JA, Hegmann KT, Jeddy Z, Lauring AS, Lutrick K, Martin ET, Mathenge C, Meece J, Midgley CM, Monto AS, Newes-Adeyi G, Odame-Bamfo L, Olsho LEW, Phillips AL, Rai RP, Saydah S, Smith N, Steinhardt L, Tyner H, Vandermeer M, Vaughan M, Yoon SK, Gaglani M, Naleway AL
JAMA 2024 Feb 6;331(5):408-416. doi: 10.1001/jama.2023.27022. PMID: 38319331Free PMC Article
Villar J, Soto Conti CP, Gunier RB, Ariff S, Craik R, Cavoretto PI, Rauch S, Gandino S, Nieto R, Winsey A, Menis C, Rodriguez GB, Savasi V, Tug N, Deantoni S, Fabre M, Martinez de Tejada B, Rodriguez-Sibaja MJ, Livio S, Napolitano R, Maiz N, Sobrero H, Peterson A, Deruelle P, Giudice C, Teji JS, Casale RA, Salomon LJ, Prefumo F, Cheikh Ismail L, Gravett MG, Vale M, Hernández V, Sentilhes L, Easter SR, Capelli C, Marler E, Cáceres DM, Albornoz Crespo G, Ernawati E, Lipschuetz M, Takahashi K, Vecchiarelli C, Hubka T, Ikenoue S, Tavchioska G, Bako B, Ayede AI, Eskenazi B, Thornton JG, Bhutta ZA, Kennedy SH, Papageorghiou AT; INTERCOVID-2022 International Consortium
Lancet 2023 Feb 11;401(10375):447-457. Epub 2023 Jan 17 doi: 10.1016/S0140-6736(22)02467-9. PMID: 36669520Free PMC Article
Sekkarie A, Woodruff R, Whitaker M, Kramer MR, Zapata LB, Ellington SR, Meaney-Delman DM, Pham H, Patel K, Taylor CA, Chai SJ, Kawasaki B, Meek J, Openo KP, Weigel A, Leegwater L, Como-Sabetti K, Ropp SL, Muse A, Bennett NM, Billing LM, Sutton M, Talbot HK, Hill M, Havers FP; COVID-19-Associated Hospitalization Surveillance Network COVID-NET Surveillance Team
Am J Obstet Gynecol MFM 2022 Nov;4(6):100715. Epub 2022 Aug 12 doi: 10.1016/j.ajogmf.2022.100715. PMID: 35970493Free PMC Article
Marra AR, Kobayashi T, Suzuki H, Alsuhaibani M, Tofaneto BM, Bariani LM, Auler MA, Salinas JL, Edmond MB, Doll M, Kutner JM, Pinho JRR, Rizzo LV, Miraglia JL, Schweizer ML
J Infect 2022 Mar;84(3):297-310. Epub 2022 Jan 1 doi: 10.1016/j.jinf.2021.12.035. PMID: 34982962Free PMC Article
Murillo-Zamora E, Mendoza-Cano O, Delgado-Enciso I, Hernandez-Suarez CM
Public Health 2021 Apr;193:113-115. Epub 2021 Feb 12 doi: 10.1016/j.puhe.2021.01.021. PMID: 33774512Free PMC Article

Therapy

Peltan ID, Caldwell E, Admon AJ, Attia EF, Gundel SJ, Mathews KS, Nagrebetsky A, Sahetya SK, Ulysse C, Brown SM, Chang SY, Goodwin AJ, Hope AA, Iwashyna TJ, Johnson NJ, Lanspa MJ, Richardson LD, Vranas KC, Angus DC, Baron RM, Haaland BA, Hayden DL, Thompson BT, Rice TW, Hough CL
Am J Crit Care 2022 Mar 1;31(2):146-157. doi: 10.4037/ajcc2022549. PMID: 34709373Free PMC Article
Ader F, Bouscambert-Duchamp M, Hites M, Peiffer-Smadja N, Poissy J, Belhadi D, Diallo A, Lê MP, Peytavin G, Staub T, Greil R, Guedj J, Paiva JA, Costagliola D, Yazdanpanah Y, Burdet C, Mentré F; DisCoVeRy Study Group
Lancet Infect Dis 2022 Feb;22(2):209-221. Epub 2021 Sep 14 doi: 10.1016/S1473-3099(21)00485-0. PMID: 34534511Free PMC Article
Al Kaabi N, Zhang Y, Xia S, Yang Y, Al Qahtani MM, Abdulrazzaq N, Al Nusair M, Hassany M, Jawad JS, Abdalla J, Hussein SE, Al Mazrouei SK, Al Karam M, Li X, Yang X, Wang W, Lai B, Chen W, Huang S, Wang Q, Yang T, Liu Y, Ma R, Hussain ZM, Khan T, Saifuddin Fasihuddin M, You W, Xie Z, Zhao Y, Jiang Z, Zhao G, Zhang Y, Mahmoud S, ElTantawy I, Xiao P, Koshy A, Zaher WA, Wang H, Duan K, Pan A, Yang X
JAMA 2021 Jul 6;326(1):35-45. doi: 10.1001/jama.2021.8565. PMID: 34037666Free PMC Article
Folegatti PM, Ewer KJ, Aley PK, Angus B, Becker S, Belij-Rammerstorfer S, Bellamy D, Bibi S, Bittaye M, Clutterbuck EA, Dold C, Faust SN, Finn A, Flaxman AL, Hallis B, Heath P, Jenkin D, Lazarus R, Makinson R, Minassian AM, Pollock KM, Ramasamy M, Robinson H, Snape M, Tarrant R, Voysey M, Green C, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group
Lancet 2020 Aug 15;396(10249):467-478. Epub 2020 Jul 20 doi: 10.1016/S0140-6736(20)31604-4. PMID: 32702298Free PMC Article
Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, Skipper CP, Nascene AA, Nicol MR, Abassi M, Engen NW, Cheng MP, LaBar D, Lother SA, MacKenzie LJ, Drobot G, Marten N, Zarychanski R, Kelly LE, Schwartz IS, McDonald EG, Rajasingham R, Lee TC, Hullsiek KH
N Engl J Med 2020 Aug 6;383(6):517-525. Epub 2020 Jun 3 doi: 10.1056/NEJMoa2016638. PMID: 32492293Free PMC Article

Prognosis

Peltan ID, Caldwell E, Admon AJ, Attia EF, Gundel SJ, Mathews KS, Nagrebetsky A, Sahetya SK, Ulysse C, Brown SM, Chang SY, Goodwin AJ, Hope AA, Iwashyna TJ, Johnson NJ, Lanspa MJ, Richardson LD, Vranas KC, Angus DC, Baron RM, Haaland BA, Hayden DL, Thompson BT, Rice TW, Hough CL
Am J Crit Care 2022 Mar 1;31(2):146-157. doi: 10.4037/ajcc2022549. PMID: 34709373Free PMC Article
Yeh R, Elsakka A, Wray R, Johnston RP, Gangai NC, Yarmohammadi H, Schoder H, Pandit-Taskar N
Clin Imaging 2021 Dec;80:262-267. Epub 2021 Aug 8 doi: 10.1016/j.clinimag.2021.08.002. PMID: 34418873Free PMC Article
Robles-Pérez E, González-Díaz B, Miranda-García M, Borja-Aburto VH
Scand J Work Environ Health 2021 Jul 1;47(5):349-355. Epub 2021 May 31 doi: 10.5271/sjweh.3970. PMID: 34057188Free PMC Article
Murillo-Zamora E, Mendoza-Cano O, Delgado-Enciso I, Hernandez-Suarez CM
Public Health 2021 Apr;193:113-115. Epub 2021 Feb 12 doi: 10.1016/j.puhe.2021.01.021. PMID: 33774512Free PMC Article
Wu Q, Xing Y, Shi L, Li W, Gao Y, Pan S, Wang Y, Wang W, Xing Q
Pediatrics 2020 Jul;146(1) Epub 2020 May 6 doi: 10.1542/peds.2020-0961. PMID: 32376725

Clinical prediction guides

Villar J, Soto Conti CP, Gunier RB, Ariff S, Craik R, Cavoretto PI, Rauch S, Gandino S, Nieto R, Winsey A, Menis C, Rodriguez GB, Savasi V, Tug N, Deantoni S, Fabre M, Martinez de Tejada B, Rodriguez-Sibaja MJ, Livio S, Napolitano R, Maiz N, Sobrero H, Peterson A, Deruelle P, Giudice C, Teji JS, Casale RA, Salomon LJ, Prefumo F, Cheikh Ismail L, Gravett MG, Vale M, Hernández V, Sentilhes L, Easter SR, Capelli C, Marler E, Cáceres DM, Albornoz Crespo G, Ernawati E, Lipschuetz M, Takahashi K, Vecchiarelli C, Hubka T, Ikenoue S, Tavchioska G, Bako B, Ayede AI, Eskenazi B, Thornton JG, Bhutta ZA, Kennedy SH, Papageorghiou AT; INTERCOVID-2022 International Consortium
Lancet 2023 Feb 11;401(10375):447-457. Epub 2023 Jan 17 doi: 10.1016/S0140-6736(22)02467-9. PMID: 36669520Free PMC Article
Sekkarie A, Woodruff R, Whitaker M, Kramer MR, Zapata LB, Ellington SR, Meaney-Delman DM, Pham H, Patel K, Taylor CA, Chai SJ, Kawasaki B, Meek J, Openo KP, Weigel A, Leegwater L, Como-Sabetti K, Ropp SL, Muse A, Bennett NM, Billing LM, Sutton M, Talbot HK, Hill M, Havers FP; COVID-19-Associated Hospitalization Surveillance Network COVID-NET Surveillance Team
Am J Obstet Gynecol MFM 2022 Nov;4(6):100715. Epub 2022 Aug 12 doi: 10.1016/j.ajogmf.2022.100715. PMID: 35970493Free PMC Article
Ader F, Bouscambert-Duchamp M, Hites M, Peiffer-Smadja N, Poissy J, Belhadi D, Diallo A, Lê MP, Peytavin G, Staub T, Greil R, Guedj J, Paiva JA, Costagliola D, Yazdanpanah Y, Burdet C, Mentré F; DisCoVeRy Study Group
Lancet Infect Dis 2022 Feb;22(2):209-221. Epub 2021 Sep 14 doi: 10.1016/S1473-3099(21)00485-0. PMID: 34534511Free PMC Article
Murillo-Zamora E, Mendoza-Cano O, Delgado-Enciso I, Hernandez-Suarez CM
Public Health 2021 Apr;193:113-115. Epub 2021 Feb 12 doi: 10.1016/j.puhe.2021.01.021. PMID: 33774512Free PMC Article
Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, Skipper CP, Nascene AA, Nicol MR, Abassi M, Engen NW, Cheng MP, LaBar D, Lother SA, MacKenzie LJ, Drobot G, Marten N, Zarychanski R, Kelly LE, Schwartz IS, McDonald EG, Rajasingham R, Lee TC, Hullsiek KH
N Engl J Med 2020 Aug 6;383(6):517-525. Epub 2020 Jun 3 doi: 10.1056/NEJMoa2016638. PMID: 32492293Free PMC Article

Recent systematic reviews

Ciapponi A, Berrueta M, Argento FJ, Ballivian J, Bardach A, Brizuela ME, Castellana N, Comandé D, Gottlieb S, Kampmann B, Mazzoni A, Parker EPK, Sambade JM, Stegelmann K, Xiong X, Stergachis A, Buekens P
Drug Saf 2024 Oct;47(10):991-1010. Epub 2024 Jul 15 doi: 10.1007/s40264-024-01458-w. PMID: 39009928Free PMC Article
Wang X, Haeussler K, Spellman A, Phillips LE, Ramiller A, Bausch-Jurken MT, Sharma P, Krivelyova A, Vats S, Van de Velde N
Front Immunol 2023;14:1204831. Epub 2023 Sep 12 doi: 10.3389/fimmu.2023.1204831. PMID: 37771594Free PMC Article
Sabeena S, Ravishankar N, Robin S, Pillai SS
Indian J Public Health 2023 Apr-Jun;67(2):284-291. doi: 10.4103/ijph.ijph_1334_22. PMID: 37459026
Baradaran HR, Dehghanbanadaki H, Moradpour F, Eshrati B, Moradi G, Azami M, Haji Ghadery A, Mehrabi Nejad MM, Moradi Y
Expert Rev Vaccines 2022 Oct;21(10):1455-1464. Epub 2022 Jul 22 doi: 10.1080/14760584.2022.2102001. PMID: 35830883
Marra AR, Kobayashi T, Suzuki H, Alsuhaibani M, Tofaneto BM, Bariani LM, Auler MA, Salinas JL, Edmond MB, Doll M, Kutner JM, Pinho JRR, Rizzo LV, Miraglia JL, Schweizer ML
J Infect 2022 Mar;84(3):297-310. Epub 2022 Jan 1 doi: 10.1016/j.jinf.2021.12.035. PMID: 34982962Free PMC Article

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