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Abnormal Schwann cell morphology

MedGen UID:
1741566
•Concept ID:
C5421564
•
Finding
Synonyms: Abnormal neurilemmal cell morphology; Abnormal neurilemmocyte morphology
 
HPO: HP:0033035

Definition

Abnormality of schwann cells, glial cells that ensheath axons of neurons in the peripheral nervous system and are necessary for their maintenance and function. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal Schwann cell morphology

Professional guidelines

PubMed

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Mesenchymal stem cells as a treatment for multiple sclerosis: a focus on experimental animal studies.
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Charcot-Marie-Tooth neuropathies: diagnosis and management.
Jani-Acsadi A, Krajewski K, Shy ME
Semin Neurol 2008 Apr;28(2):185-94. doi: 10.1055/s-2008-1062264. PMID: 18351520

Recent clinical studies

Therapy

Drug-Induced Demyelinating Neuropathies.
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Molecular mechanisms of inherited demyelinating neuropathies.
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Glia 2008 Nov 1;56(14):1578-1589. doi: 10.1002/glia.20751. PMID: 18803325Free PMC Article
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Curr Opin Neurol 2004 Oct;17(5):579-85. doi: 10.1097/00019052-200410000-00008. PMID: 15367862

Prognosis

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Pipis M, Won S, Poh R, Efthymiou S, Polke JM, Skorupinska M, Blake J, Rossor AM, Moran JJ, Munot P, Muntoni F, Laura M, Svaren J, Reilly MM
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Moss KR, Bopp TS, Johnson AE, Höke A
Neurosci Lett 2021 Jan 23;744:135595. Epub 2020 Dec 24 doi: 10.1016/j.neulet.2020.135595. PMID: 33359733Free PMC Article
Nodopathies of the peripheral nerve: an emerging concept.
Uncini A, Kuwabara S
J Neurol Neurosurg Psychiatry 2015 Nov;86(11):1186-95. Epub 2015 Feb 19 doi: 10.1136/jnnp-2014-310097. PMID: 25699569
Intrapulmonary schwannoma.
Ohtsuka T, Nomori H, Naruke T, Orikasa H, Yamazaki K, Suemasu K
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Clin Lab Med 1986 Mar;6(1):103-16. doi: 10.1016/S0272-2712(18)30828-X. PMID: 3514094Free PMC Article

Clinical prediction guides

Dysregulation of myelination-related genes in schizophrenia.
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Origin and initiation mechanisms of neuroblastoma.
Tsubota S, Kadomatsu K
Cell Tissue Res 2018 May;372(2):211-221. Epub 2018 Feb 14 doi: 10.1007/s00441-018-2796-z. PMID: 29445860

Recent systematic reviews

Intraneural perineurioma: a systematic review with illustrative cases.
Boyanton BL Jr, Jones JK, Shenaq SM, Hicks MJ, Bhattacharjee MB
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