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Absent TSH response to thyrotrophin-releasing hormone stimulation test

MedGen UID:
1725687
•Concept ID:
C5421595
•
Finding
HPO: HP:0033081

Definition

Failure to increase serum TSH levels in response to a TRH stimulation test. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbsent TSH response to thyrotrophin-releasing hormone stimulation test

Professional guidelines

PubMed

Monitoring treatment of congenital hypothyroidism by highly sensitive immunoradiometric assay for thyroid stimulating hormone.
Sato H, Inomata H, Sasaki N, Niimi H, Nakajima H
Endocrinol Jpn 1987 Aug;34(4):569-75. doi: 10.1507/endocrj1954.34.569. PMID: 3119318
Long-term treatment of acromegaly with bromocryptine: postprandial HGH levels and response to TRH and glucose administration.
Benker G, Zäh W, Hackenberg K, Hamburger B, Günnewig H, Reinwein D
Horm Metab Res 1976 Jul;8(4):291-5. doi: 10.1055/s-0028-1093638. PMID: 182633

Recent clinical studies

Therapy

Circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors.
Darzy KH, Shalet SM
J Clin Endocrinol Metab 2005 Dec;90(12):6490-7. Epub 2005 Oct 4 doi: 10.1210/jc.2005-1593. PMID: 16204362
Thyrotropin (TSH)-releasing hormone stimulation test responses employing third and fourth generation TSH assays.
Spencer CA, Schwarzbein D, Guttler RB, LoPresti JS, Nicoloff JT
J Clin Endocrinol Metab 1993 Feb;76(2):494-8. doi: 10.1210/jcem.76.2.8432796. PMID: 8432796
Thyrotropin releasing hormone does not stimulate prolactin release in the preterm human fetus.
Roti E, Gardini E, Minelli R, Bianconi L, Alboni A, Braverman LE
Acta Endocrinol (Copenh) 1990 Apr;122(4):462-6. doi: 10.1530/acta.0.1220462. PMID: 2110411
Oral thyrotropin-releasing hormone (TRH) test in acromegaly.
Marek J, Límanová Z, Srámková J
Endokrinologie 1981 Oct;78(1):57-66. PMID: 6797816
Suppression of the TSH response to TRH by thyroxine therapy in differentiated thyroid carcinoma patients.
Lamberg BA, Rantanen M, Saarinen P, Liewendahl K, Sivula A
Acta Endocrinol (Copenh) 1979 Jun;91(2):248-56. doi: 10.1530/acta.0.0910248. PMID: 111446

Prognosis

The secretion of human growth hormone stimulated by human growth hormone releasing factor following severe cranio-cerebral trauma.
Gottardis M, Nigitsch C, Schmutzhard E, Neumann M, Putensen C, Hackl JM, Koller W
Intensive Care Med 1990;16(3):163-6. doi: 10.1007/BF01724795. PMID: 2112565
Use of a sensitive thyrotropin assay for monitoring treatment with levothyroxine.
Watts NB
Arch Intern Med 1989 Feb;149(2):309-12. PMID: 2644903
Changes in basal and stimulated TSH and other parameters of thyroid function in acromegaly after transsphenoidal surgery.
Geelhoed-Duijvestijn PH, Bussemaker JK, Roelfsema F
Acta Endocrinol (Copenh) 1989 Aug;121(2):207-15. doi: 10.1530/acta.0.1210207. PMID: 2505466

Clinical prediction guides

Immeasurably low and non-TRH-stimulatable TSH associated with normal I-123 uptake in two goitrous euthyroid patients: possible existence of other thyroid-hormone regulated thyroid stimulators other than TSH.
Ikekubo K, Hino M, Saiki Y, Son C, Iwakura T, Kobayashi H, Ishihara T
Endocr J 2005 Feb;52(1):61-8. doi: 10.1507/endocrj.52.61. PMID: 15758559
The secretion of human growth hormone stimulated by human growth hormone releasing factor following severe cranio-cerebral trauma.
Gottardis M, Nigitsch C, Schmutzhard E, Neumann M, Putensen C, Hackl JM, Koller W
Intensive Care Med 1990;16(3):163-6. doi: 10.1007/BF01724795. PMID: 2112565
Use of a sensitive thyrotropin assay for monitoring treatment with levothyroxine.
Watts NB
Arch Intern Med 1989 Feb;149(2):309-12. PMID: 2644903
Human serum thyrotrophin measurement by ultrasensitive immunoradiometric assay as a first-line test in the evaluation of thyroid function.
Martino E, Bambini G, Bartalena L, Mammoli C, Aghini-Lombardi F, Baschieri L, Pinchera A
Clin Endocrinol (Oxf) 1986 Feb;24(2):141-8. doi: 10.1111/j.1365-2265.1986.tb00756.x. PMID: 3085992
Stimulation of growth hormone release by luteinizing hormone-releasing hormone in two males with isolated gonadotropin deficiency.
Kasagi K, Oishi M, Nishikawa M, Kurata S, Inada M, Kato Y, Imura H
Endocrinol Jpn 1976 Oct;23(5):383-90. doi: 10.1507/endocrj1954.23.383. PMID: 827432

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