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Chemotherapy-induced alopecia

MedGen UID:
1720394
•Concept ID:
C5236021
•
Disease or Syndrome
Synonyms: Chemotherapy-Induced Alopecia; chemotherapy-induced alopecia
 
Monarch Initiative: MONDO:0005483

Definition

Alopecia caused by treatment with chemotherapeutic agents. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChemotherapy-induced alopecia

Professional guidelines

PubMed

Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?
Wikramanayake TC, Haberland NI, Akhundlu A, Laboy Nieves A, Miteva M
Curr Oncol 2023 Mar 25;30(4):3609-3626. doi: 10.3390/curroncol30040275. PMID: 37185388Free PMC Article
Prevention and management of dermatological toxicities related to anticancer agents: ESMO Clinical Practice Guidelines(☆).
Lacouture ME, Sibaud V, Gerber PA, van den Hurk C, Fernández-Peñas P, Santini D, Jahn F, Jordan K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Feb;32(2):157-170. Epub 2020 Nov 25 doi: 10.1016/j.annonc.2020.11.005. PMID: 33248228
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136

Recent clinical studies

Etiology

Scalp Cooling in Preventing Persistent Chemotherapy-Induced Alopecia: A Randomized Controlled Trial.
Kang D, Cho J, Zhao D, Kim J, Kim N, Kim H, Kim S, Kim JY, Park YH, Im YH, Guallar E, Ahn JS
J Clin Oncol 2024 Sep 10;42(26):3115-3122. Epub 2024 Jun 6 doi: 10.1200/JCO.23.02374. PMID: 38843479
Effectiveness, Safety, and Tolerance of Scalp Cooling for Chemotherapy-Induced Alopecia.
Zhang XY, Yang KL, Liu WQ, Huang J, Ning N
Oncol Nurs Forum 2022 Jun 17;49(4):369-384. doi: 10.1188/22.ONF.369-384. PMID: 35788740
Scalp cooling to prevent chemotherapy-induced alopecia.
Silva GB, Ciccolini K, Donati A, Hurk CVD
An Bras Dermatol 2020 Sep-Oct;95(5):631-637. Epub 2020 Jun 16 doi: 10.1016/j.abd.2020.03.005. PMID: 32622629Free PMC Article
Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial.
Nangia J, Wang T, Osborne C, Niravath P, Otte K, Papish S, Holmes F, Abraham J, Lacouture M, Courtright J, Paxman R, Rude M, Hilsenbeck S, Osborne CK, Rimawi M
JAMA 2017 Feb 14;317(6):596-605. doi: 10.1001/jama.2016.20939. PMID: 28196254
Chemotherapy-induced alopecia management: Clinical experience and practical advice.
Rossi A, Fortuna MC, Caro G, Pranteda G, Garelli V, Pompili U, Carlesimo M
J Cosmet Dermatol 2017 Dec;16(4):537-541. Epub 2017 Feb 2 doi: 10.1111/jocd.12308. PMID: 28150447Free PMC Article

Diagnosis

Hair loss during and after breast cancer therapy.
Rose L, Lustberg M, Ruddy KJ, Cathcart-Rake E, Loprinzi C, Dulmage B
Support Care Cancer 2023 Feb 24;31(3):186. doi: 10.1007/s00520-023-07634-5. PMID: 36826602
Permanent chemotherapy-induced alopecia: awareness and attitudes among health care providers.
Stoehr JR, Kosche C, Choi JN
Support Care Cancer 2020 Jun;28(6):2887-2890. Epub 2019 Nov 19 doi: 10.1007/s00520-019-05169-2. PMID: 31745696
Monitoring chemotherapy-induced alopecia with trichoscopy.
Rossi A, Caterina Fortuna M, Caro G, Cardone M, Garelli V, Grassi S, Carlesimo M
J Cosmet Dermatol 2019 Apr;18(2):575-580. Epub 2018 Jul 11 doi: 10.1111/jocd.12687. PMID: 29992733
Pigmented casts.
Miteva M, Romanelli P, Tosti A
Am J Dermatopathol 2014 Jan;36(1):58-63. doi: 10.1097/DAD.0b013e3182919ac7. PMID: 23823025
Anagen effluvium.
Kanwar AJ, Narang T
Indian J Dermatol Venereol Leprol 2013 Sep-Oct;79(5):604-12. doi: 10.4103/0378-6323.116728. PMID: 23974578

Therapy

Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?
Wikramanayake TC, Haberland NI, Akhundlu A, Laboy Nieves A, Miteva M
Curr Oncol 2023 Mar 25;30(4):3609-3626. doi: 10.3390/curroncol30040275. PMID: 37185388Free PMC Article
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136
Scalp cooling to prevent chemotherapy-induced alopecia.
Silva GB, Ciccolini K, Donati A, Hurk CVD
An Bras Dermatol 2020 Sep-Oct;95(5):631-637. Epub 2020 Jun 16 doi: 10.1016/j.abd.2020.03.005. PMID: 32622629Free PMC Article
Off-Label Use of Topical Minoxidil in Alopecia: A Review.
Stoehr JR, Choi JN, Colavincenzo M, Vanderweil S
Am J Clin Dermatol 2019 Apr;20(2):237-250. doi: 10.1007/s40257-018-0409-y. PMID: 30604379
Hair disorders in patients with cancer.
Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME
J Am Acad Dermatol 2019 May;80(5):1179-1196. Epub 2018 Apr 14 doi: 10.1016/j.jaad.2018.03.055. PMID: 29660422Free PMC Article

Prognosis

Chemotherapy-Induced Alopecia: Examining Patient Perceptions and Adherence to Home Haircare Recommendations.
Sitarz J, Spencer C
Clin J Oncol Nurs 2022 Apr 1;26(2):190-197. doi: 10.1188/22.CJON.190-197. PMID: 35302555
Patient-reported outcome assessment and objective evaluation of chemotherapy-induced alopecia.
Komen MMC, van den Hurk CJG, Nortier JWR, van der Ploeg T, Smorenburg CH, van der Hoeven JJM
Eur J Oncol Nurs 2018 Apr;33:49-55. Epub 2018 Feb 3 doi: 10.1016/j.ejon.2018.01.001. PMID: 29551177
Management of Chemotherapy-Induced Alopecia With Scalp Cooling.
Kruse M, Abraham J
J Oncol Pract 2018 Mar;14(3):149-154. doi: 10.1200/JOP.17.00038. PMID: 29529389
A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention.
Dunnill CJ, Al-Tameemi W, Collett A, Haslam IS, Georgopoulos NT
Oncologist 2018 Jan;23(1):84-96. Epub 2017 Sep 26 doi: 10.1634/theoncologist.2017-0263. PMID: 28951499Free PMC Article
Clinical characteristics of chemotherapy-induced alopecia in childhood.
Choi M, Kim MS, Park SY, Park GH, Jo SJ, Cho KH, Lee JW, Park KD, Shin HY, Kang HJ, Kwon O
J Am Acad Dermatol 2014 Mar;70(3):499-505. Epub 2013 Dec 16 doi: 10.1016/j.jaad.2013.10.034. PMID: 24355411

Clinical prediction guides

Chemotherapy-Induced Alopecia: Examining Patient Perceptions and Adherence to Home Haircare Recommendations.
Sitarz J, Spencer C
Clin J Oncol Nurs 2022 Apr 1;26(2):190-197. doi: 10.1188/22.CJON.190-197. PMID: 35302555
Monitoring chemotherapy-induced alopecia with trichoscopy.
Rossi A, Caterina Fortuna M, Caro G, Cardone M, Garelli V, Grassi S, Carlesimo M
J Cosmet Dermatol 2019 Apr;18(2):575-580. Epub 2018 Jul 11 doi: 10.1111/jocd.12687. PMID: 29992733
Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial.
Nangia J, Wang T, Osborne C, Niravath P, Otte K, Papish S, Holmes F, Abraham J, Lacouture M, Courtright J, Paxman R, Rude M, Hilsenbeck S, Osborne CK, Rimawi M
JAMA 2017 Feb 14;317(6):596-605. doi: 10.1001/jama.2016.20939. PMID: 28196254
Pigmented casts.
Miteva M, Romanelli P, Tosti A
Am J Dermatopathol 2014 Jan;36(1):58-63. doi: 10.1097/DAD.0b013e3182919ac7. PMID: 23823025
Chemotherapy-induced alopecia: new developments.
Hussein AM
South Med J 1993 May;86(5):489-96. doi: 10.1097/00007611-199305000-00001. PMID: 8488392

Recent systematic reviews

Scalp hypothermia to reduce chemotherapy-induced alopecia: A systematic review and meta-analysis.
Lambert KA, Albright BB, Anastasio MK, Kaplan SJ, McNally L
Gynecol Oncol 2024 Sep;188:71-80. Epub 2024 Jun 26 doi: 10.1016/j.ygyno.2024.06.012. PMID: 38936283
Interventions for Preventing Chemotherapy-Induced Alopecia: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.
Zhou T, Han S, Zhu Z, Hu Y, Xing W
Cancer Nurs 2021 Nov-Dec 01;44(6):E567-E577. doi: 10.1097/NCC.0000000000000899. PMID: 33003120
Identifying the supportive care needs of men and women affected by chemotherapy-induced alopecia? A systematic review.
Paterson C, Kozlovskaia M, Turner M, Strickland K, Roberts C, Ogilvie R, Pranavan G, Craft P
J Cancer Surviv 2021 Feb;15(1):14-28. Epub 2020 Jul 18 doi: 10.1007/s11764-020-00907-6. PMID: 32683651
Low-dose oral minoxidil as treatment for non-scarring alopecia: a systematic review.
Sharma AN, Michelle L, Juhasz M, Muller Ramos P, Atanaskova Mesinkovska N
Int J Dermatol 2020 Aug;59(8):1013-1019. Epub 2020 Jun 9 doi: 10.1111/ijd.14933. PMID: 32516434
Efficacy of interventions for prevention of chemotherapy-induced alopecia: a systematic review and meta-analysis.
Shin H, Jo SJ, Kim DH, Kwon O, Myung SK
Int J Cancer 2015 Mar 1;136(5):E442-54. Epub 2014 Aug 11 doi: 10.1002/ijc.29115. PMID: 25081068

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