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Intratubular bilirubin casts

MedGen UID:: 1719858
•Concept ID:: C5397642
•: Finding

HPO:	HP:0032624

Definition

A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. On H&E (red brown), PAS (amaranth purple), trichrome (red with ragged contours), Hall (olive-emerald green). [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIntratubular bilirubin casts

Abnormality of the upper urinary tract
- Abnormality of the kidney
  - Abnormal renal morphology
    - Abnormal nephron morphology
      - Abnormal renal tubule morphology
        Renal intratubular casts
        Intratubular bilirubin casts

Recent clinical studies

Etiology

Cholemic Nephropathy Causes Acute Kidney Injury and Is Accompanied by Loss of Aquaporin 2 in Collecting Ducts.

Bräsen JH, Mederacke YS, Schmitz J, Diahovets K, Khalifa A, Hartleben B, Person F, Wiech T, Steenbergen E, Großhennig A, Manns MP, Schmitt R, Mederacke I
Hepatology 2019 May;69(5):2107-2119. Epub 2019 Mar 14 doi: 10.1002/hep.30499. PMID: 30633816

Bile Cast Nephropathy in Cirrhotic Patients: Effects of Chronic Hyperbilirubinemia.

Foshat M, Ruff HM, Fischer WG, Beach RE, Fowler MR, Ju H, Aronson JF, Afrouzian M
Am J Clin Pathol 2017 May 1;147(5):525-535. doi: 10.1093/ajcp/aqx030. PMID: 28398539

Diagnosis

Cholemic Nephropathy Causes Acute Kidney Injury and Is Accompanied by Loss of Aquaporin 2 in Collecting Ducts.

Bräsen JH, Mederacke YS, Schmitz J, Diahovets K, Khalifa A, Hartleben B, Person F, Wiech T, Steenbergen E, Großhennig A, Manns MP, Schmitt R, Mederacke I
Hepatology 2019 May;69(5):2107-2119. Epub 2019 Mar 14 doi: 10.1002/hep.30499. PMID: 30633816

Therapy

Cholemic Nephropathy Causes Acute Kidney Injury and Is Accompanied by Loss of Aquaporin 2 in Collecting Ducts.

Bräsen JH, Mederacke YS, Schmitz J, Diahovets K, Khalifa A, Hartleben B, Person F, Wiech T, Steenbergen E, Großhennig A, Manns MP, Schmitt R, Mederacke I
Hepatology 2019 May;69(5):2107-2119. Epub 2019 Mar 14 doi: 10.1002/hep.30499. PMID: 30633816

Prognosis

Cholemic Nephropathy Causes Acute Kidney Injury and Is Accompanied by Loss of Aquaporin 2 in Collecting Ducts.

Bräsen JH, Mederacke YS, Schmitz J, Diahovets K, Khalifa A, Hartleben B, Person F, Wiech T, Steenbergen E, Großhennig A, Manns MP, Schmitt R, Mederacke I
Hepatology 2019 May;69(5):2107-2119. Epub 2019 Mar 14 doi: 10.1002/hep.30499. PMID: 30633816

Clinical prediction guides

Cholemic Nephropathy Causes Acute Kidney Injury and Is Accompanied by Loss of Aquaporin 2 in Collecting Ducts.

Bräsen JH, Mederacke YS, Schmitz J, Diahovets K, Khalifa A, Hartleben B, Person F, Wiech T, Steenbergen E, Großhennig A, Manns MP, Schmitt R, Mederacke I
Hepatology 2019 May;69(5):2107-2119. Epub 2019 Mar 14 doi: 10.1002/hep.30499. PMID: 30633816

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