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Neonatal electro-clinical seizure

MedGen UID:
1718888
•Concept ID:
C5397815
•
Disease or Syndrome
Synonyms: Neonatal electro-clinical epileptic seizure; Neonatal focal electro-clinical epileptic seizure
SNOMED CT: Neonatal focal electro-clinical epileptic seizure (1287614007); Neonatal electro-clinical seizure (1287614007); Neonatal electro-clinical epileptic seizure (1287614007)
 
HPO: HP:0032809

Definition

Neonatal electro-clinical seizure is an electrographic event occurring in neonatal period and coupled with a clinical manifestation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal electro-clinical seizure

Professional guidelines

PubMed

CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients.
Le Roux M, Barth M, Gueden S, Desbordes de Cepoy P, Aeby A, Vilain C, Hirsch E, de Saint Martin A, Portes VD, Lesca G, Riquet A, Chaton L, Villeneuve N, Villard L, Cances C, Valton L, Renaldo F, Vermersch AI, Altuzarra C, Nguyen-Morel MA, Van Gils J, Angelini C, Biraben A, Arnaud L, Riant F, Van Bogaert P
Eur J Paediatr Neurol 2021 Jul;33:75-85. Epub 2021 May 26 doi: 10.1016/j.ejpn.2021.05.010. PMID: 34102571
Neonatal epilepsies: Clinical management.
Cornet MC, Sands TT, Cilio MR
Semin Fetal Neonatal Med 2018 Jun;23(3):204-212. Epub 2018 Jan 31 doi: 10.1016/j.siny.2018.01.004. PMID: 29426806
Variability in Preferred Management of Electrographic Seizures in Neonatal Hypoxic Ischemic Encephalopathy.
McNally MA, Hartman AL
Pediatr Neurol 2017 Dec;77:37-41. Epub 2017 Jun 15 doi: 10.1016/j.pediatrneurol.2017.06.006. PMID: 28982530

Recent clinical studies

Etiology

Neonatal seizures during extra corporeal membrane oxygenation support.
Chalia M, Singh D, Boyd SG, Hannam S, Hoskote A, Pressler R
Eur J Pediatr 2024 Jun;183(6):2605-2614. Epub 2024 Mar 15 doi: 10.1007/s00431-024-05510-w. PMID: 38488877
Clinical and electroencephalography characteristics of 45 patients with neonatal seizures.
Li L, Deng Y, Chen J, Xie L, Lan X, Hu Y, Hong S, Jiang L
Neurophysiol Clin 2023 Feb;53(1):102886. Epub 2023 Jun 7 doi: 10.1016/j.neucli.2023.102886. PMID: 37295040
Aggregate Channel Features for newborn face detection in Neonatal Intensive Care Units.
Olmi B, Manfredi C, Frassineti L, Dani C, Lori S, Bertini G, Gabbanini S, Lanata A
Annu Int Conf IEEE Eng Med Biol Soc 2022 Jul;2022:455-458. doi: 10.1109/EMBC48229.2022.9871399. PMID: 36085849
Neonatal epilepsy genetics.
Axeen EJT, Olson HE
Semin Fetal Neonatal Med 2018 Jun;23(3):197-203. Epub 2018 Jan 31 doi: 10.1016/j.siny.2018.01.003. PMID: 29426807
Epidemiology of idiopathic generalized epilepsies.
Jallon P, Latour P
Epilepsia 2005;46 Suppl 9:10-4. doi: 10.1111/j.1528-1167.2005.00309.x. PMID: 16302871

Diagnosis

Clinical and electroencephalography characteristics of 45 patients with neonatal seizures.
Li L, Deng Y, Chen J, Xie L, Lan X, Hu Y, Hong S, Jiang L
Neurophysiol Clin 2023 Feb;53(1):102886. Epub 2023 Jun 7 doi: 10.1016/j.neucli.2023.102886. PMID: 37295040
Electroencephalography in neonatal epilepsies.
Okumura A
Pediatr Int 2020 Sep;62(9):1019-1028. doi: 10.1111/ped.14227. PMID: 32153072
Neonatal epilepsy genetics.
Axeen EJT, Olson HE
Semin Fetal Neonatal Med 2018 Jun;23(3):197-203. Epub 2018 Jan 31 doi: 10.1016/j.siny.2018.01.003. PMID: 29426807
Neonatal epilepsies: Clinical management.
Cornet MC, Sands TT, Cilio MR
Semin Fetal Neonatal Med 2018 Jun;23(3):204-212. Epub 2018 Jan 31 doi: 10.1016/j.siny.2018.01.004. PMID: 29426806
Epilepsy and chromosomal abnormalities.
Sorge G, Sorge A
Ital J Pediatr 2010 May 3;36:36. doi: 10.1186/1824-7288-36-36. PMID: 20438626Free PMC Article

Therapy

Carbamazepine efficacy in a severe electro-clinical presentation of SLC13A5-epilepsy.
Santalucia R, Vilain C, Soblet J, De Laet C, Vuckovic A, König J, Aeby A
Ann Clin Transl Neurol 2022 Jul;9(7):1095-1099. Epub 2022 May 28 doi: 10.1002/acn3.51581. PMID: 35633140Free PMC Article
Neonatal epilepsies: Clinical management.
Cornet MC, Sands TT, Cilio MR
Semin Fetal Neonatal Med 2018 Jun;23(3):204-212. Epub 2018 Jan 31 doi: 10.1016/j.siny.2018.01.004. PMID: 29426806
Type and etiology of pediatric epilepsy in Jordan. A multi-center study.
Al-Qudah AA, Albsoul-Younes A, Masri AT, AbuRahmah SK, Alabadi IA, Nafi OA, Gharaibeh LF, Murtaja AA, Al-Sakran LH, Arabiat HA, Al-Shorman AA
Neurosciences (Riyadh) 2017 Oct;22(4):267-273. doi: 10.17712/nsj.2017.4.20170164. PMID: 29057851Free PMC Article
Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives.
Donovan MD, Griffin BT, Kharoshankaya L, Cryan JF, Boylan GB
Drugs 2016 Apr;76(6):647-61. doi: 10.1007/s40265-016-0554-7. PMID: 26943929
Seizures and adverse events during routine scalp electroencephalography: a clinical and EEG analysis of 1000 records.
Angus-Leppan H
Clin Neurophysiol 2007 Jan;118(1):22-30. Epub 2006 Oct 6 doi: 10.1016/j.clinph.2006.08.014. PMID: 17030013

Prognosis

Neonatal seizures during extra corporeal membrane oxygenation support.
Chalia M, Singh D, Boyd SG, Hannam S, Hoskote A, Pressler R
Eur J Pediatr 2024 Jun;183(6):2605-2614. Epub 2024 Mar 15 doi: 10.1007/s00431-024-05510-w. PMID: 38488877
Clinical and electroencephalography characteristics of 45 patients with neonatal seizures.
Li L, Deng Y, Chen J, Xie L, Lan X, Hu Y, Hong S, Jiang L
Neurophysiol Clin 2023 Feb;53(1):102886. Epub 2023 Jun 7 doi: 10.1016/j.neucli.2023.102886. PMID: 37295040
Electro-clinical and neurodevelopmental outcome in six children with early diagnosis of tuberous sclerosis complex and role of the genetic background.
Savini MN, Mingarelli A, Peron A, La Briola F, Cervi F, Alfano RM, Canevini MP, Vignoli A
Ital J Pediatr 2020 Mar 27;46(1):36. doi: 10.1186/s13052-020-0801-0. PMID: 32216820Free PMC Article
Epidemiology of idiopathic generalized epilepsies.
Jallon P, Latour P
Epilepsia 2005;46 Suppl 9:10-4. doi: 10.1111/j.1528-1167.2005.00309.x. PMID: 16302871
Neonatal seizures.
Rennie JM
Eur J Pediatr 1997 Feb;156(2):83-7. doi: 10.1007/s004310050559. PMID: 9039506

Clinical prediction guides

Expanding the spectrum of neonatal-onset AIFM1-associated disorders.
Zambon AA, Ghezzi D, Baldoli C, Cutillo G, Fontana K, Sofia V, Patricelli MG, Nasca A, Vinci S, Spiga I, Lamantea E, Fanelli GF, Sora MGN, Rovelli R, Poloniato A, Carrera P, Filippi M, Barera G
Ann Clin Transl Neurol 2023 Oct;10(10):1844-1853. Epub 2023 Aug 29 doi: 10.1002/acn3.51876. PMID: 37644805Free PMC Article
Electroencephalographic characteristics of epileptic seizures in preterm neonates.
Janáčková S, Boyd S, Yozawitz E, Tsuchida T, Lamblin MD, Gueden S, Pressler R
Clin Neurophysiol 2016 Aug;127(8):2721-2727. Epub 2016 May 24 doi: 10.1016/j.clinph.2016.05.006. PMID: 27417043
Seizures and EEG features in 74 patients with genetic-dysmorphic syndromes.
Alfei E, Raviglione F, Franceschetti S, D'Arrigo S, Milani D, Selicorni A, Riva D, Zuffardi O, Pantaleoni C, Binelli S
Am J Med Genet A 2014 Dec;164A(12):3154-61. Epub 2014 Sep 24 doi: 10.1002/ajmg.a.36746. PMID: 25257908
Epilepsies and epileptic syndromes starting in the neonatal period.
Yamamoto H, Okumura A, Fukuda M
Brain Dev 2011 Mar;33(3):213-20. Epub 2010 Nov 9 doi: 10.1016/j.braindev.2010.10.009. PMID: 21067877
Epidemiology of idiopathic generalized epilepsies.
Jallon P, Latour P
Epilepsia 2005;46 Suppl 9:10-4. doi: 10.1111/j.1528-1167.2005.00309.x. PMID: 16302871

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