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GVHD Organ

MedGen UID:
1716898
•Concept ID:
C5239198
•
Finding

Definition

The organs involved in the graft vs host disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGVHD Organ

Professional guidelines

PubMed

Off-the-shelf bone marrow-derived mesenchymal stem cell treatment for acute graft-versus-host disease: real-world evidence.
Murata M, Terakura S, Wake A, Miyao K, Ikegame K, Uchida N, Kataoka K, Miyamoto T, Onizuka M, Eto T, Doki N, Ota S, Sato M, Hashii Y, Ichinohe T, Fukuda T, Atsuta Y, Okamoto S, Teshima T
Bone Marrow Transplant 2021 Oct;56(10):2355-2366. Epub 2021 May 11 doi: 10.1038/s41409-021-01304-y. PMID: 33976381
Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report.
Lee SJ, Wolff D, Kitko C, Koreth J, Inamoto Y, Jagasia M, Pidala J, Olivieri A, Martin PJ, Przepiorka D, Pusic I, Dignan F, Mitchell SA, Lawitschka A, Jacobsohn D, Hall AM, Flowers ME, Schultz KR, Vogelsang G, Pavletic S
Biol Blood Marrow Transplant 2015 Jun;21(6):984-99. Epub 2015 Mar 19 doi: 10.1016/j.bbmt.2015.02.025. PMID: 25796139Free PMC Article

Recent clinical studies

Etiology

Characteristics of Graft-Versus-Host Disease (GvHD) After Post-Transplantation Cyclophosphamide Versus Conventional GvHD Prophylaxis.
Saliba RM, Alousi AM, Pidala J, Arora M, Spellman SR, Hemmer MT, Wang T, Abboud C, Ahmed S, Antin JH, Beitinjaneh A, Buchbinder D, Byrne M, Cahn JY, Choe H, Hanna R, Hematti P, Kamble RT, Kitko CL, Laughlin M, Lekakis L, MacMillan ML, Martino R, Mehta PA, Nishihori T, Patel SS, Perales MA, Rangarajan HG, Ringdén O, Rosenthal J, Savani BN, Schultz KR, Seo S, Teshima T, van der Poel M, Verdonck LF, Weisdorf D, Wirk B, Yared JA, Schriber J, Champlin RE, Ciurea SO
Transplant Cell Ther 2022 Oct;28(10):681-693. Epub 2022 Jul 16 doi: 10.1016/j.jtct.2022.07.013. PMID: 35853610Free PMC Article
Risk Factors for Ocular Involvement in Pediatric Graft-Versus-Host Disease.
Hébert M, Archambault C, Doyon C, Ospina LH, Robert MC
Cornea 2021 Sep 1;40(9):1158-1164. doi: 10.1097/ICO.0000000000002659. PMID: 33470680
Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report.
Lee SJ, Wolff D, Kitko C, Koreth J, Inamoto Y, Jagasia M, Pidala J, Olivieri A, Martin PJ, Przepiorka D, Pusic I, Dignan F, Mitchell SA, Lawitschka A, Jacobsohn D, Hall AM, Flowers ME, Schultz KR, Vogelsang G, Pavletic S
Biol Blood Marrow Transplant 2015 Jun;21(6):984-99. Epub 2015 Mar 19 doi: 10.1016/j.bbmt.2015.02.025. PMID: 25796139Free PMC Article
Extracorporeal photopheresis in steroid-refractory acute or chronic graft-versus-host disease: results of a systematic review of prospective studies.
Abu-Dalle I, Reljic T, Nishihori T, Antar A, Bazarbachi A, Djulbegovic B, Kumar A, Kharfan-Dabaja MA
Biol Blood Marrow Transplant 2014 Nov;20(11):1677-86. Epub 2014 May 24 doi: 10.1016/j.bbmt.2014.05.017. PMID: 24867779
NCI, NHLBI first international consensus conference on late effects after pediatric hematopoietic cell transplantation: etiology and pathogenesis of late effects after HCT performed in childhood--methodologic challenges.
Bhatia S, Davies SM, Scott Baker K, Pulsipher MA, Hansen JA
Biol Blood Marrow Transplant 2011 Oct;17(10):1428-35. Epub 2011 Jul 18 doi: 10.1016/j.bbmt.2011.07.005. PMID: 21763253Free PMC Article

Diagnosis

Characteristics of Graft-Versus-Host Disease (GvHD) After Post-Transplantation Cyclophosphamide Versus Conventional GvHD Prophylaxis.
Saliba RM, Alousi AM, Pidala J, Arora M, Spellman SR, Hemmer MT, Wang T, Abboud C, Ahmed S, Antin JH, Beitinjaneh A, Buchbinder D, Byrne M, Cahn JY, Choe H, Hanna R, Hematti P, Kamble RT, Kitko CL, Laughlin M, Lekakis L, MacMillan ML, Martino R, Mehta PA, Nishihori T, Patel SS, Perales MA, Rangarajan HG, Ringdén O, Rosenthal J, Savani BN, Schultz KR, Seo S, Teshima T, van der Poel M, Verdonck LF, Weisdorf D, Wirk B, Yared JA, Schriber J, Champlin RE, Ciurea SO
Transplant Cell Ther 2022 Oct;28(10):681-693. Epub 2022 Jul 16 doi: 10.1016/j.jtct.2022.07.013. PMID: 35853610Free PMC Article
Risk Factors for Ocular Involvement in Pediatric Graft-Versus-Host Disease.
Hébert M, Archambault C, Doyon C, Ospina LH, Robert MC
Cornea 2021 Sep 1;40(9):1158-1164. doi: 10.1097/ICO.0000000000002659. PMID: 33470680
Organ toxicity and quality of life after allogeneic bone marrow transplantation in pediatric patients: a single centre retrospective analysis.
Matthes-Martin S, Lamche M, Ladenstein R, Emminger W, Felsberger C, Topf R, Gadner H, Peters C
Bone Marrow Transplant 1999 May;23(10):1049-53. doi: 10.1038/sj.bmt.1701754. PMID: 10373072

Therapy

IFN-γR/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease.
Lu C, Ma H, Song L, Wang H, Wang L, Li S, Lagana SM, Sepulveda AR, Hoebe K, Pan SS, Yang YG, Lentzsch S, Mapara MY
J Clin Invest 2023 Feb 1;133(3) doi: 10.1172/JCI125986. PMID: 36445781Free PMC Article
Characteristics of Graft-Versus-Host Disease (GvHD) After Post-Transplantation Cyclophosphamide Versus Conventional GvHD Prophylaxis.
Saliba RM, Alousi AM, Pidala J, Arora M, Spellman SR, Hemmer MT, Wang T, Abboud C, Ahmed S, Antin JH, Beitinjaneh A, Buchbinder D, Byrne M, Cahn JY, Choe H, Hanna R, Hematti P, Kamble RT, Kitko CL, Laughlin M, Lekakis L, MacMillan ML, Martino R, Mehta PA, Nishihori T, Patel SS, Perales MA, Rangarajan HG, Ringdén O, Rosenthal J, Savani BN, Schultz KR, Seo S, Teshima T, van der Poel M, Verdonck LF, Weisdorf D, Wirk B, Yared JA, Schriber J, Champlin RE, Ciurea SO
Transplant Cell Ther 2022 Oct;28(10):681-693. Epub 2022 Jul 16 doi: 10.1016/j.jtct.2022.07.013. PMID: 35853610Free PMC Article
Risk Factors for Ocular Involvement in Pediatric Graft-Versus-Host Disease.
Hébert M, Archambault C, Doyon C, Ospina LH, Robert MC
Cornea 2021 Sep 1;40(9):1158-1164. doi: 10.1097/ICO.0000000000002659. PMID: 33470680
Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report.
Lee SJ, Wolff D, Kitko C, Koreth J, Inamoto Y, Jagasia M, Pidala J, Olivieri A, Martin PJ, Przepiorka D, Pusic I, Dignan F, Mitchell SA, Lawitschka A, Jacobsohn D, Hall AM, Flowers ME, Schultz KR, Vogelsang G, Pavletic S
Biol Blood Marrow Transplant 2015 Jun;21(6):984-99. Epub 2015 Mar 19 doi: 10.1016/j.bbmt.2015.02.025. PMID: 25796139Free PMC Article
Extracorporeal photopheresis in steroid-refractory acute or chronic graft-versus-host disease: results of a systematic review of prospective studies.
Abu-Dalle I, Reljic T, Nishihori T, Antar A, Bazarbachi A, Djulbegovic B, Kumar A, Kharfan-Dabaja MA
Biol Blood Marrow Transplant 2014 Nov;20(11):1677-86. Epub 2014 May 24 doi: 10.1016/j.bbmt.2014.05.017. PMID: 24867779

Prognosis

Risk Factors for Ocular Involvement in Pediatric Graft-Versus-Host Disease.
Hébert M, Archambault C, Doyon C, Ospina LH, Robert MC
Cornea 2021 Sep 1;40(9):1158-1164. doi: 10.1097/ICO.0000000000002659. PMID: 33470680
What predicts high risk acute graft-versus-host disease (GVHD) at onset?: identification of those at highest risk by a novel acute GVHD risk score.
MacMillan ML, DeFor TE, Weisdorf DJ
Br J Haematol 2012 Jun;157(6):732-41. Epub 2012 Apr 6 doi: 10.1111/j.1365-2141.2012.09114.x. PMID: 22486355Free PMC Article
NCI, NHLBI first international consensus conference on late effects after pediatric hematopoietic cell transplantation: etiology and pathogenesis of late effects after HCT performed in childhood--methodologic challenges.
Bhatia S, Davies SM, Scott Baker K, Pulsipher MA, Hansen JA
Biol Blood Marrow Transplant 2011 Oct;17(10):1428-35. Epub 2011 Jul 18 doi: 10.1016/j.bbmt.2011.07.005. PMID: 21763253Free PMC Article

Clinical prediction guides

IFN-γR/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease.
Lu C, Ma H, Song L, Wang H, Wang L, Li S, Lagana SM, Sepulveda AR, Hoebe K, Pan SS, Yang YG, Lentzsch S, Mapara MY
J Clin Invest 2023 Feb 1;133(3) doi: 10.1172/JCI125986. PMID: 36445781Free PMC Article
What predicts high risk acute graft-versus-host disease (GVHD) at onset?: identification of those at highest risk by a novel acute GVHD risk score.
MacMillan ML, DeFor TE, Weisdorf DJ
Br J Haematol 2012 Jun;157(6):732-41. Epub 2012 Apr 6 doi: 10.1111/j.1365-2141.2012.09114.x. PMID: 22486355Free PMC Article
Organ toxicity and quality of life after allogeneic bone marrow transplantation in pediatric patients: a single centre retrospective analysis.
Matthes-Martin S, Lamche M, Ladenstein R, Emminger W, Felsberger C, Topf R, Gadner H, Peters C
Bone Marrow Transplant 1999 May;23(10):1049-53. doi: 10.1038/sj.bmt.1701754. PMID: 10373072

Recent systematic reviews

Extracorporeal photopheresis in steroid-refractory acute or chronic graft-versus-host disease: results of a systematic review of prospective studies.
Abu-Dalle I, Reljic T, Nishihori T, Antar A, Bazarbachi A, Djulbegovic B, Kumar A, Kharfan-Dabaja MA
Biol Blood Marrow Transplant 2014 Nov;20(11):1677-86. Epub 2014 May 24 doi: 10.1016/j.bbmt.2014.05.017. PMID: 24867779

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