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Renal interstitial hemorrhage

MedGen UID:: 1715002
•Concept ID:: C5397638
•: Pathologic Function

Synonym:	Renal interstitial haemorrhage

HPO:	HP:0032617

Definition

A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRenal interstitial hemorrhage

Abnormality of the genitourinary system
- Abnormality of the urinary system
  - Abnormality of the upper urinary tract
    - Abnormality of the kidney
      - Abnormal renal morphology
        Abnormal renal insterstitial morphology
        Renal interstitial hemorrhage

Professional guidelines

PubMed

Management of acute kidney injury in symptomatic multiple myeloma.

Bridoux F, Leung N, Belmouaz M, Royal V, Ronco P, Nasr SH, Fermand JP; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2021 Mar;99(3):570-580. Epub 2021 Jan 10 doi: 10.1016/j.kint.2020.11.010. PMID: 33440212

Urine Sediment Examination in the Diagnosis and Management of Kidney Disease: Core Curriculum 2019.

Cavanaugh C, Perazella MA
Am J Kidney Dis 2019 Feb;73(2):258-272. Epub 2018 Sep 21 doi: 10.1053/j.ajkd.2018.07.012. PMID: 30249419

International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.

Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS
Blood 2017 Mar 23;129(12):1646-1657. Epub 2017 Jan 13 doi: 10.1182/blood-2016-10-746933. PMID: 28087540 Free PMC Article

See all (113)

Recent clinical studies

Etiology

Imaging findings of COPA Syndrome.

Nguyen HN, Salman R, Vogel TP, Silva-Carmona M, DeGuzman M, Guillerman RP
Pediatr Radiol 2023 May;53(5):844-853. Epub 2023 Feb 7 doi: 10.1007/s00247-023-05600-1. PMID: 36746811

The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.

Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394 Free PMC Article

Monoclonal gammopathies of renal significance.

Caravaca-Fontán F, Gutiérrez E, Delgado Lillo R, Praga M
Nefrologia 2017 Sep-Oct;37(5):465-477. doi: 10.1016/j.nefro.2017.03.012. PMID: 28946960

International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.

IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.

Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001

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Diagnosis

Glomerulonephritis Histopathological Pattern Change.

AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R
BMC Nephrol 2020 May 18;21(1):186. doi: 10.1186/s12882-020-01836-3. PMID: 32423387 Free PMC Article

Renal involvement in IgG4-related disease.

Boffa JJ, Esteve E, Buob D
Presse Med 2020 Apr;49(1):104017. Epub 2020 Mar 29 doi: 10.1016/j.lpm.2020.104017. PMID: 32234380

IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.

Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001

IgG4-related kidney disease.

Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849

IgG4-related kidney disease.

Cornell LD
Semin Diagn Pathol 2012 Nov;29(4):245-50. doi: 10.1053/j.semdp.2012.07.004. PMID: 23068304

See all (1473)

Therapy

Mouse Models of Diabetes, Obesity and Related Kidney Disease.

Glastras SJ, Chen H, Teh R, McGrath RT, Chen J, Pollock CA, Wong MG, Saad S
PLoS One 2016;11(8):e0162131. Epub 2016 Aug 31 doi: 10.1371/journal.pone.0162131. PMID: 27579698 Free PMC Article

IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.

Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001

IgG4-related kidney disease.

Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849

IgG4-related kidney disease.

Cornell LD
Semin Diagn Pathol 2012 Nov;29(4):245-50. doi: 10.1053/j.semdp.2012.07.004. PMID: 23068304

Snakebite nephropathy.

Sitprija V
Nephrology (Carlton) 2006 Oct;11(5):442-8. doi: 10.1111/j.1440-1797.2006.00599.x. PMID: 17014559

See all (1443)

Prognosis

Comparative study on clinicopathological features and prognosis of IgA vasculitis nephritis and IgA nephropathy in children.

Lv Y, Fu R, Peng XJ, Wang Y, Yin TT, Deng YQ
BMC Pediatr 2023 Aug 24;23(1):423. doi: 10.1186/s12887-023-04243-3. PMID: 37620917 Free PMC Article

Acute Kidney Injury in Cancer Immunotherapy Recipients.

Joseph A, Lafarge A, Azoulay E, Zafrani L
Cells 2022 Dec 10;11(24) doi: 10.3390/cells11243991. PMID: 36552755 Free PMC Article

The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors.

Seethapathy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, Cortazar FB, Leaf DE, Mooradian MJ, Villani AC, Sullivan RJ, Reynolds K, Sise ME
Clin J Am Soc Nephrol 2019 Dec 6;14(12):1692-1700. Epub 2019 Oct 31 doi: 10.2215/CJN.00990119. PMID: 31672794 Free PMC Article

Monoclonal gammopathies of renal significance.

Caravaca-Fontán F, Gutiérrez E, Delgado Lillo R, Praga M
Nefrologia 2017 Sep-Oct;37(5):465-477. doi: 10.1016/j.nefro.2017.03.012. PMID: 28946960

IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.

Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001

See all (1194)

Clinical prediction guides

Glomerulonephritis Histopathological Pattern Change.

AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R
BMC Nephrol 2020 May 18;21(1):186. doi: 10.1186/s12882-020-01836-3. PMID: 32423387 Free PMC Article

Fluid Volume Overload and Congestion in Heart Failure: Time to Reconsider Pathophysiology and How Volume Is Assessed.

Miller WL
Circ Heart Fail 2016 Aug;9(8):e002922. doi: 10.1161/CIRCHEARTFAILURE.115.002922. PMID: 27436837

IgG4-related kidney disease.

Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849

IgG4-related kidney disease.

Cornell LD
Semin Diagn Pathol 2012 Nov;29(4):245-50. doi: 10.1053/j.semdp.2012.07.004. PMID: 23068304

Leptospiral nephropathy.

Sitprija V, Losuwanrak K, Kanjanabuch T
Semin Nephrol 2003 Jan;23(1):42-8. doi: 10.1053/snep.2003.50004. PMID: 12563600

See all (1308)

Recent systematic reviews

The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases.

Genovese F, Bager C, Frederiksen P, Vazquez D, Sand JMB, Jenkins RG, Maher TM, Stewart ID, Molyneaux PL, Fahy WA, Wain LV, Vestbo J, Nanthakumar C, Shaker SB, Hoyer N, Leeming DJ, George J, Trebicka J, Rasmussen DGK, Hansen MK, Cockwell P, Kremer D, Bakker SJ, Selby NM, Reese-Petersen AL, González A, Núñez J, Rossing P, Nissen NI, Boisen MK, Chen IM, Zhao L, Karsdal MA, Schuppan D
Matrix Biol 2024 Sep;132:1-9. Epub 2024 Jun 11 doi: 10.1016/j.matbio.2024.06.003. PMID: 38871093

Potential Renal Damage Biomarkers in Alport Syndrome-A Review of the Literature.

Gomes AM, Lopes D, Almeida C, Santos S, Malheiro J, Lousa I, Caldas Afonso A, Beirão I
Int J Mol Sci 2022 Jun 30;23(13) doi: 10.3390/ijms23137276. PMID: 35806283 Free PMC Article

Biopsy-proven kidney involvement in hypocomplementemic urticarial vasculitis.

Corthier A, Jachiet M, Bertin D, Servais A, Barbet C, Bigot A, Doutre MS, Bessis D, Bouffandeau A, Moranne O, Jarrot PA, Bardin N, Terrier B, Burtey S, Puéchal X, Daniel L, Jourde-Chiche N
BMC Nephrol 2022 Feb 16;23(1):67. doi: 10.1186/s12882-022-02689-8. PMID: 35172758 Free PMC Article

Survival after lung transplantation in systemic sclerosis. A systematic review.

Khan IY, Singer LG, de Perrot M, Granton JT, Keshavjee S, Chau C, Kron A, Johnson SR
Respir Med 2013 Dec;107(12):2081-7. Epub 2013 Sep 26 doi: 10.1016/j.rmed.2013.09.015. PMID: 24113572

Evaluation of the Oxford Classification of IgA nephropathy: a systematic review and meta-analysis.

Lv J, Shi S, Xu D, Zhang H, Troyanov S, Cattran DC, Wang H
Am J Kidney Dis 2013 Nov;62(5):891-9. Epub 2013 Jun 29 doi: 10.1053/j.ajkd.2013.04.021. PMID: 23820066

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Renal interstitial hemorrhage

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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