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Focal aware bilateral motor seizure

MedGen UID:
1714577
•Concept ID:
C5397862
•
Disease or Syndrome
HPO: HP:0032856

Definition

A type of focal bilateral motor seizure during which awareness is fully retained throughout. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal aware bilateral motor seizure

Professional guidelines

PubMed

Radiofrequency ablation of the centromedian thalamic nucleus in the treatment of drug-resistant epilepsy.
Aguado-Carrillo G, Velasco AL, Saucedo-Alvarado PE, Cuellar-Herrera M, Trejo-Martínez D, Navarro-Olvera JL, Heres-Becerril SD, Barrera-Domínguez ED, Velasco-Campos F
Epilepsy Behav 2021 Jan;114(Pt A):107560. Epub 2020 Nov 24 doi: 10.1016/j.yebeh.2020.107560. PMID: 33243680
Hypothalamic hamartomas in adulthood: Clinical spectrum and treatment outcome-A unicenter experience.
Conde Blanco E, Anciones Martín C, Manzanares I, Gil López F, Roldán P, Donaire A, Rumiá J, Carreño M
Brain Behav 2019 Nov;9(11):e01412. Epub 2019 Oct 2 doi: 10.1002/brb3.1412. PMID: 31578831Free PMC Article
The phenotype of bilateral hippocampal sclerosis and its management in "real life" clinical settings.
Sen A, Dugan P, Perucca P, Costello D, Choi H, Bazil C, Radtke R, Andrade D, Depondt C, Heavin S, Adcock J, Pickrell WO, McGinty RN, Nascimento F, Smith P, Rees MI, Kwan P, O'Brien TJ, Goldstein D, Delanty N
Epilepsia 2018 Jul;59(7):1410-1420. Epub 2018 Jun 14 doi: 10.1111/epi.14436. PMID: 29901232

Recent clinical studies

Etiology

Sudden unexpected death in epilepsy during cenobamate clinical development.
Rosenfeld WE, Ferrari L, Kerr WT, Sperling MR
Epilepsia 2023 Aug;64(8):2108-2115. Epub 2023 Jun 5 doi: 10.1111/epi.17662. PMID: 37219391
Focal epilepsies: Update on diagnosis and classification.
Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103
Hemispheric epilepsy.
Blume WT
Brain 1998 Oct;121 ( Pt 10):1937-49. doi: 10.1093/brain/121.10.1937. PMID: 9798748

Diagnosis

Focal epilepsies: Update on diagnosis and classification.
Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Dravet syndrome in children-A population-based study.
Bjurulf B, Reilly C, Sigurdsson GV, Thunström S, Kolbjer S, Hallböök T
Epilepsy Res 2022 May;182:106922. Epub 2022 Apr 8 doi: 10.1016/j.eplepsyres.2022.106922. PMID: 35461153
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Epilepsy Overview and Revised Classification of Seizures and Epilepsies.
Pack AM
Continuum (Minneap Minn) 2019 Apr;25(2):306-321. doi: 10.1212/CON.0000000000000707. PMID: 30921011
Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.
Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM
Epilepsia 2017 Apr;58(4):522-530. Epub 2017 Mar 8 doi: 10.1111/epi.13670. PMID: 28276060

Therapy

Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention.
Cutillo G, Tolba H, Hirsch LJ
Epilepsy Behav 2021 Apr;117:107815. Epub 2021 Feb 26 doi: 10.1016/j.yebeh.2021.107815. PMID: 33640562
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Prognosis

Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
Distribution of postictal slowing has an additional yield to interictal epileptiform discharge in predicting surgical outcomes in temporal lobe epilepsy.
Shaaban S, Kakisaka Y, Belal T, Jin K, Osawa SI, Tominaga T, Elmenshawi I, Nakasato N
Epilepsia Open 2022 Dec;7(4):802-809. Epub 2022 Oct 29 doi: 10.1002/epi4.12660. PMID: 36225084Free PMC Article
Epilepsy and EEG Abnormalities in Children with Autism Spectrum Disorders.
Sharma V, Saini AG, Malhi P, Singhi P
Indian J Pediatr 2022 Oct;89(10):975-982. Epub 2021 Nov 29 doi: 10.1007/s12098-021-03928-w. PMID: 34843062
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500
Hemispheric epilepsy.
Blume WT
Brain 1998 Oct;121 ( Pt 10):1937-49. doi: 10.1093/brain/121.10.1937. PMID: 9798748

Clinical prediction guides

Diabetes ketoacidosis and Recurrent Childhood Stroke-like Episodes.
Liu RC, Sheu JN, Liu CS, Tsai JD
Acta Neurol Taiwan 2024 Mar 30;33(1):41-42. PMID: 37853548
Duration of epileptic seizure types: A data-driven approach.
Meritam Larsen P, Wüstenhagen S, Terney D, Gardella E, Aurlien H, Beniczky S
Epilepsia 2023 Feb;64(2):469-478. Epub 2023 Jan 3 doi: 10.1111/epi.17492. PMID: 36597206Free PMC Article
Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
Focal impaired awareness seizures in a rodent model: A functional anatomy.
Adotevi N, Kapur J
Epilepsia Open 2022 Mar;7(1):110-123. Epub 2021 Dec 17 doi: 10.1002/epi4.12563. PMID: 34822222Free PMC Article
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Recent systematic reviews

Dyke-Davidoff-Masson Syndrome: Main clinical and radiological findings- systematic literature review.
Rondão MBA, Hsu BRRHS, Centeno RS, de Aguiar PHP
Seizure 2023 Aug;110:58-68. Epub 2023 Jun 3 doi: 10.1016/j.seizure.2023.04.020. PMID: 37327751
Optimal timing of interictal FDG-PET for epilepsy surgery: A systematic review on time since last seizure.
de Laat NN, Tolboom N, Leijten FSS
Epilepsia Open 2022 Sep;7(3):512-517. Epub 2022 Jun 20 doi: 10.1002/epi4.12617. PMID: 35666076Free PMC Article
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention.
Cutillo G, Tolba H, Hirsch LJ
Epilepsy Behav 2021 Apr;117:107815. Epub 2021 Feb 26 doi: 10.1016/j.yebeh.2021.107815. PMID: 33640562

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