U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Focal impaired awareness bilateral motor seizure

MedGen UID:
1713986
•Concept ID:
C5397724
•
Disease or Syndrome
HPO: HP:0032714

Definition

A focal bilateral motor seizure characterized by impairment of awareness at some point during the seizure. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal impaired awareness bilateral motor seizure

Professional guidelines

PubMed

Efficacy and safety of adjunctive perampanel treatment in pediatric patients with epilepsy aged 4-12 years: a real-world study.
Zeng Q, Xia X, Jiang L, Chen J, Liu Y, Hu Y
J Neurol 2024 Jul;271(7):4566-4576. Epub 2024 May 8 doi: 10.1007/s00415-024-12416-y. PMID: 38717610
Hypothalamic hamartomas in adulthood: Clinical spectrum and treatment outcome-A unicenter experience.
Conde Blanco E, Anciones Martín C, Manzanares I, Gil López F, Roldán P, Donaire A, Rumiá J, Carreño M
Brain Behav 2019 Nov;9(11):e01412. Epub 2019 Oct 2 doi: 10.1002/brb3.1412. PMID: 31578831Free PMC Article
Genotype/phenotype of 6 Chinese cases with Niemann-Pick disease type C.
Xiong H, Higaki K, Wei CJ, Bao XH, Zhang YH, Fu N, Qin J, Adachi K, Kumura Y, Ninomiya H, Nanba E, Wu XR
Gene 2012 May 1;498(2):332-5. Epub 2012 Feb 4 doi: 10.1016/j.gene.2012.01.026. PMID: 22326530

Recent clinical studies

Etiology

Focal epilepsies: Update on diagnosis and classification.
Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Duration of postictal impaired awareness after bilateral tonic-clonic seizures: EEG and patient characteristics.
Kanth KM, Zimmerman CS, Toprani SC, Seyal M
Epilepsy Behav 2022 Mar;128:108576. Epub 2022 Feb 2 doi: 10.1016/j.yebeh.2022.108576. PMID: 35123240
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Diagnosis

Diabetes ketoacidosis and Recurrent Childhood Stroke-like Episodes.
Liu RC, Sheu JN, Liu CS, Tsai JD
Acta Neurol Taiwan 2024 Mar 30;33(1):41-42. PMID: 37853548
Focal epilepsies: Update on diagnosis and classification.
Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Conversational analysis of consciousness during seizures.
Uchitel J, McDade C, Mathew M, Mantri S, Jenson D, Husain AM
Epilepsy Behav 2020 Nov;112:107486. Epub 2020 Sep 29 doi: 10.1016/j.yebeh.2020.107486. PMID: 33181894
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Therapy

Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention.
Cutillo G, Tolba H, Hirsch LJ
Epilepsy Behav 2021 Apr;117:107815. Epub 2021 Feb 26 doi: 10.1016/j.yebeh.2021.107815. PMID: 33640562
Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?
Guignet M, Campbell A, White HS
Epilepsia 2020 Nov;61(11):2329-2339. Epub 2020 Oct 16 doi: 10.1111/epi.16718. PMID: 33063849
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Prognosis

Characterization of seizures and EEG findings in creatine transporter deficiency due to SLC6A8 mutation.
Abdennadher M, Inati SK, Rahhal S, Khan O, Bartolini L, Thurm A, Theodore W, Miller JS, Porter FD, Bianconi S
Am J Med Genet A 2024 Feb;194(2):337-345. Epub 2023 Oct 18 doi: 10.1002/ajmg.a.63418. PMID: 37850681
Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.
Juan E, Górska U, Kozma C, Papantonatos C, Bugnon T, Denis C, Kremen V, Worrell G, Struck AF, Bateman LM, Merricks EM, Blumenfeld H, Tononi G, Schevon C, Boly M
Brain 2023 Jan 5;146(1):109-123. doi: 10.1093/brain/awac291. PMID: 36383415Free PMC Article
Distribution of postictal slowing has an additional yield to interictal epileptiform discharge in predicting surgical outcomes in temporal lobe epilepsy.
Shaaban S, Kakisaka Y, Belal T, Jin K, Osawa SI, Tominaga T, Elmenshawi I, Nakasato N
Epilepsia Open 2022 Dec;7(4):802-809. Epub 2022 Oct 29 doi: 10.1002/epi4.12660. PMID: 36225084Free PMC Article
Cluster analysis: Predicting the seizure outcome in temporal lobe epilepsy.
Asadi-Pooya AA, Farazdaghi M
Epilepsy Behav 2022 Jan;126:108495. Epub 2021 Dec 16 doi: 10.1016/j.yebeh.2021.108495. PMID: 34923259
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Clinical prediction guides

Diabetes ketoacidosis and Recurrent Childhood Stroke-like Episodes.
Liu RC, Sheu JN, Liu CS, Tsai JD
Acta Neurol Taiwan 2024 Mar 30;33(1):41-42. PMID: 37853548
Duration of epileptic seizure types: A data-driven approach.
Meritam Larsen P, Wüstenhagen S, Terney D, Gardella E, Aurlien H, Beniczky S
Epilepsia 2023 Feb;64(2):469-478. Epub 2023 Jan 3 doi: 10.1111/epi.17492. PMID: 36597206Free PMC Article
Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.
Juan E, Górska U, Kozma C, Papantonatos C, Bugnon T, Denis C, Kremen V, Worrell G, Struck AF, Bateman LM, Merricks EM, Blumenfeld H, Tononi G, Schevon C, Boly M
Brain 2023 Jan 5;146(1):109-123. doi: 10.1093/brain/awac291. PMID: 36383415Free PMC Article
Focal impaired awareness seizures in a rodent model: A functional anatomy.
Adotevi N, Kapur J
Epilepsia Open 2022 Mar;7(1):110-123. Epub 2021 Dec 17 doi: 10.1002/epi4.12563. PMID: 34822222Free PMC Article
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Recent systematic reviews

Dyke-Davidoff-Masson Syndrome: Main clinical and radiological findings- systematic literature review.
Rondão MBA, Hsu BRRHS, Centeno RS, de Aguiar PHP
Seizure 2023 Aug;110:58-68. Epub 2023 Jun 3 doi: 10.1016/j.seizure.2023.04.020. PMID: 37327751
Optimal timing of interictal FDG-PET for epilepsy surgery: A systematic review on time since last seizure.
de Laat NN, Tolboom N, Leijten FSS
Epilepsia Open 2022 Sep;7(3):512-517. Epub 2022 Jun 20 doi: 10.1002/epi4.12617. PMID: 35666076Free PMC Article
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention.
Cutillo G, Tolba H, Hirsch LJ
Epilepsy Behav 2021 Apr;117:107815. Epub 2021 Feb 26 doi: 10.1016/j.yebeh.2021.107815. PMID: 33640562

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...