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Moist Desquamation

MedGen UID:
1713798
•Concept ID:
C5237171
•
Sign or Symptom

Definition

A skin reaction characterized by sloughing of the epidermis and serous exudate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMoist Desquamation

Professional guidelines

PubMed

Radiotherapy-induced skin reactions: assessment and management.
Glover D, Harmer V
Br J Nurs 2014 Feb 27-Mar 12;23(4):S28, S30-5. doi: 10.12968/bjon.2014.23.Sup2.S28. PMID: 24619051
Evidence-based skin care management in radiation therapy.
McQuestion M
Semin Oncol Nurs 2006 Aug;22(3):163-73. doi: 10.1016/j.soncn.2006.04.004. PMID: 16893745
Concurrent ifosfamide-based chemotherapy and irradiation. Analysis of treatment-related toxicity in 43 patients with sarcoma.
Cormier JN, Patel SR, Herzog CE, Ballo MT, Burgess MA, Feig BW, Hunt KK, Raney RB, Zagars GK, Benjamin RS, Pisters PW
Cancer 2001 Sep 15;92(6):1550-5. doi: 10.1002/1097-0142(20010915)92:6<1550::aid-cncr1481>3.0.co;2-c. PMID: 11745234

Recent clinical studies

Etiology

Prevention of radiation dermatitis with skin hygiene and washing: a systematic review and meta-analysis.
Chan DCW, Wong HCY, Riad MA, Caini S, Wolf JR, van den Hurk C, Beveridge M, Lam H, Bonomo P, Chow E, Behroozian T
Support Care Cancer 2023 Apr 22;31(5):294. doi: 10.1007/s00520-023-07720-8. PMID: 37086339
Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial.
Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J, Gallant F, Rakovitch E, Tran W, Soliman H, Leung E, Vesprini D, Szumacher E, Chen H, Donovan E, Lam J, Spadafora S, Wronski M, Lavoie C, Walde N, Lam E, Wong G, McKenzie E, Ariello K, Kennedy S, Shariati S, Carothers K, Gonzales G, Kagan Y, Chow E
J Clin Oncol 2023 Feb 20;41(6):1250-1264. Epub 2022 Dec 9 doi: 10.1200/JCO.22.01873. PMID: 36493331
Modeling Cutaneous Radiation Injury from Fallout.
Adams TG, Yeddanapudi N, Clay M, Asher J, Appler J, Casagrande R
Disaster Med Public Health Prep 2019 Jun;13(3):463-469. Epub 2018 Aug 31 doi: 10.1017/dmp.2018.74. PMID: 30168409
Radiodermatitis: A Review of Our Current Understanding.
Singh M, Alavi A, Wong R, Akita S
Am J Clin Dermatol 2016 Jun;17(3):277-92. doi: 10.1007/s40257-016-0186-4. PMID: 27021652
Radiotherapy-induced skin reactions: assessment and management.
Glover D, Harmer V
Br J Nurs 2014 Feb 27-Mar 12;23(4):S28, S30-5. doi: 10.12968/bjon.2014.23.Sup2.S28. PMID: 24619051

Diagnosis

Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients.
Duzenli C, Chan EK, Koulis T, Grahame S, Singer J, Morris D, Spence J, Lee T, Burns L, Olson RA
Curr Oncol 2022 Jul 7;29(7):4734-4747. doi: 10.3390/curroncol29070376. PMID: 35877236Free PMC Article
Development of an Illustrated Scale for Acute Radiation Dermatitis in Breast Cancer Patients.
Shumway DA, Kapadia N, Walker EM, Griffith KA, Do TT, Feng M, Boike T, Helfrich Y, DePalma B, Gillespie EF, Miller A, Hayman J, Jagsi R, Pierce LJ
Pract Radiat Oncol 2021 May-Jun;11(3):168-176. Epub 2020 Sep 16 doi: 10.1016/j.prro.2020.09.002. PMID: 32947041
Radiotherapy for patients with unresected locally advanced breast cancer.
Yee C, Alayed Y, Drost L, Karam I, Vesprini D, McCann C, Soliman H, Zhang L, Chow E, Chan S, Lee J
Ann Palliat Med 2018 Oct;7(4):373-384. Epub 2018 Jun 12 doi: 10.21037/apm.2018.05.13. PMID: 30180725
Radiodermatitis: A Review of Our Current Understanding.
Singh M, Alavi A, Wong R, Akita S
Am J Clin Dermatol 2016 Jun;17(3):277-92. doi: 10.1007/s40257-016-0186-4. PMID: 27021652
Prospective evaluation of severe skin toxicity and pain during postmastectomy radiation therapy.
Pignol JP, Vu TT, Mitera G, Bosnic S, Verkooijen HM, Truong P
Int J Radiat Oncol Biol Phys 2015 Jan 1;91(1):157-64. doi: 10.1016/j.ijrobp.2014.09.022. PMID: 25835623

Therapy

Radiotherapy-induced Pathology of the Ear.
Brooks KA, Gross JH
Otolaryngol Clin North Am 2023 Oct;56(5):977-985. Epub 2023 Jul 4 doi: 10.1016/j.otc.2023.05.013. PMID: 37414656
Bacterial Decolonization for Prevention of Radiation Dermatitis: A Randomized Clinical Trial.
Kost Y, Deutsch A, Mieczkowska K, Nazarian R, Muskat A, Hosgood HD, Lin J, Daily JP, Ohri N, Kabarriti R, Shinoda K, McLellan BN
JAMA Oncol 2023 Jul 1;9(7):940-945. doi: 10.1001/jamaoncol.2023.0444. PMID: 37140904Free PMC Article
Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial.
Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J, Gallant F, Rakovitch E, Tran W, Soliman H, Leung E, Vesprini D, Szumacher E, Chen H, Donovan E, Lam J, Spadafora S, Wronski M, Lavoie C, Walde N, Lam E, Wong G, McKenzie E, Ariello K, Kennedy S, Shariati S, Carothers K, Gonzales G, Kagan Y, Chow E
J Clin Oncol 2023 Feb 20;41(6):1250-1264. Epub 2022 Dec 9 doi: 10.1200/JCO.22.01873. PMID: 36493331
Radiodermatitis: A Review of Our Current Understanding.
Singh M, Alavi A, Wong R, Akita S
Am J Clin Dermatol 2016 Jun;17(3):277-92. doi: 10.1007/s40257-016-0186-4. PMID: 27021652
Radiotherapy-induced skin reactions: assessment and management.
Glover D, Harmer V
Br J Nurs 2014 Feb 27-Mar 12;23(4):S28, S30-5. doi: 10.12968/bjon.2014.23.Sup2.S28. PMID: 24619051

Prognosis

Development of an Illustrated Scale for Acute Radiation Dermatitis in Breast Cancer Patients.
Shumway DA, Kapadia N, Walker EM, Griffith KA, Do TT, Feng M, Boike T, Helfrich Y, DePalma B, Gillespie EF, Miller A, Hayman J, Jagsi R, Pierce LJ
Pract Radiat Oncol 2021 May-Jun;11(3):168-176. Epub 2020 Sep 16 doi: 10.1016/j.prro.2020.09.002. PMID: 32947041
Effectiveness and Acceptability of a Moisturizing Cream and a Barrier Cream During Radiation Therapy for Breast Cancer in the Tropics: A Randomized Controlled Trial.
Laffin N, Smyth W, Heyer E, Fasugba O, Abernethy G, Gardner A
Cancer Nurs 2015 May-Jun;38(3):205-14. doi: 10.1097/NCC.0000000000000161. PMID: 24945268
Radiotherapy-induced skin reactions: prevention and cure.
Morgan K
Br J Nurs 2014 Sep 11-24;23(16):S24, S26-32. doi: 10.12968/bjon.2014.23.Sup16.S24. PMID: 25203851
Evaluation the consistency of location of moist desquamation and skin high dose area for breast cancer patients receiving adjuvant radiotherapy after breast conservative surgery.
Sun LM, Huang EY, Liang JA, Meng FY, Chang GH, Tsao MJ
Radiat Oncol 2013 Mar 6;8:50. doi: 10.1186/1748-717X-8-50. PMID: 23497574Free PMC Article
Medical and surgical management for localized radiation injuries.
Nénot JC
Int J Radiat Biol 1990 Apr;57(4):783-95. doi: 10.1080/09553009014550931. PMID: 1969907

Clinical prediction guides

Mepitel Film for the prevention of acute radiation dermatitis in head and neck cancer: a systematic review and meta-analysis of randomized controlled trials.
Lee SF, Wong HCY, Chan AW, Caini S, Shariati S, Rades D, Chan RJ, Kennedy SKF, Wolf JR, van den Hurk C, Behroozian T, Bonomo P, Ho FCH, Chow E, Herst P
Support Care Cancer 2023 Aug 18;31(9):527. doi: 10.1007/s00520-023-07988-w. PMID: 37594538
Bacterial Decolonization for Prevention of Radiation Dermatitis: A Randomized Clinical Trial.
Kost Y, Deutsch A, Mieczkowska K, Nazarian R, Muskat A, Hosgood HD, Lin J, Daily JP, Ohri N, Kabarriti R, Shinoda K, McLellan BN
JAMA Oncol 2023 Jul 1;9(7):940-945. doi: 10.1001/jamaoncol.2023.0444. PMID: 37140904Free PMC Article
Prevention of radiation dermatitis with skin hygiene and washing: a systematic review and meta-analysis.
Chan DCW, Wong HCY, Riad MA, Caini S, Wolf JR, van den Hurk C, Beveridge M, Lam H, Bonomo P, Chow E, Behroozian T
Support Care Cancer 2023 Apr 22;31(5):294. doi: 10.1007/s00520-023-07720-8. PMID: 37086339
Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial.
Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J, Gallant F, Rakovitch E, Tran W, Soliman H, Leung E, Vesprini D, Szumacher E, Chen H, Donovan E, Lam J, Spadafora S, Wronski M, Lavoie C, Walde N, Lam E, Wong G, McKenzie E, Ariello K, Kennedy S, Shariati S, Carothers K, Gonzales G, Kagan Y, Chow E
J Clin Oncol 2023 Feb 20;41(6):1250-1264. Epub 2022 Dec 9 doi: 10.1200/JCO.22.01873. PMID: 36493331
Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy.
Gong P, Dai G, Wu X, Wang X, Xie L, Xu S, Zhong R
Breast 2022 Dec;66:317-323. Epub 2022 Nov 29 doi: 10.1016/j.breast.2022.11.008. PMID: 36463642Free PMC Article

Recent systematic reviews

Mepitel Film for the prevention of acute radiation dermatitis in head and neck cancer: a systematic review and meta-analysis of randomized controlled trials.
Lee SF, Wong HCY, Chan AW, Caini S, Shariati S, Rades D, Chan RJ, Kennedy SKF, Wolf JR, van den Hurk C, Behroozian T, Bonomo P, Ho FCH, Chow E, Herst P
Support Care Cancer 2023 Aug 18;31(9):527. doi: 10.1007/s00520-023-07988-w. PMID: 37594538
Topical corticosteroids for the prevention of severe radiation dermatitis: a systematic review and meta-analysis.
Tam S, Zhou G, Trombetta M, Caini S, Ryan Wolf J, van den Hurk C, Beveridge M, Lam H, Bonomo P, Chow E, Behroozian T
Support Care Cancer 2023 Jun 6;31(7):382. doi: 10.1007/s00520-023-07820-5. PMID: 37280403
Prevention of radiation dermatitis with skin hygiene and washing: a systematic review and meta-analysis.
Chan DCW, Wong HCY, Riad MA, Caini S, Wolf JR, van den Hurk C, Beveridge M, Lam H, Bonomo P, Chow E, Behroozian T
Support Care Cancer 2023 Apr 22;31(5):294. doi: 10.1007/s00520-023-07720-8. PMID: 37086339
Radiodermatitis in Patients With Cancer: Systematic Review and Meta-Analysis.
Ginex PK, Backler C, Croson E, Horrell LN, Moriarty KA, Maloney C, Vrabel M, Morgan RL
Oncol Nurs Forum 2020 Nov 1;47(6):E225-E236. doi: 10.1188/20.ONF.E225-E236. PMID: 33063778
Effectiveness of semi-permeable dressings to treat radiation-induced skin reactions. A systematic review.
Fernández-Castro M, Martín-Gil B, Peña-García I, López-Vallecillo M, García-Puig ME
Eur J Cancer Care (Engl) 2017 Nov;26(6) Epub 2017 Apr 18 doi: 10.1111/ecc.12685. PMID: 28417508

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