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Neonatal electrographic only seizure

MedGen UID:
1713608
•Concept ID:
C5397817
•
Disease or Syndrome
Synonyms: Neonatal electrographic-only seizure; Neonatal focal electrographic-only epileptic seizure
SNOMED CT: Neonatal focal electrographic-only epileptic seizure (1287615008); Neonatal electrographic-only seizure (1287615008)
 
HPO: HP:0032811

Definition

Neonatal electrographic only seizure is an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end, which is not associated with a clinical manifestation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal electrographic only seizure

Professional guidelines

PubMed

Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Variability in Preferred Management of Electrographic Seizures in Neonatal Hypoxic Ischemic Encephalopathy.
McNally MA, Hartman AL
Pediatr Neurol 2017 Dec;77:37-41. Epub 2017 Jun 15 doi: 10.1016/j.pediatrneurol.2017.06.006. PMID: 28982530
Electroencephalographic criteria for nonconvulsive status epilepticus: synopsis and comprehensive survey.
Sutter R, Kaplan PW
Epilepsia 2012 Aug;53 Suppl 3:1-51. doi: 10.1111/j.1528-1167.2012.03593.x. PMID: 22862158

Recent clinical studies

Etiology

Remote Monitoring for Seizures During Therapeutic Hypothermia in Neonates With Hypoxic-Ischemic Encephalopathy.
Variane GFT, Dahlen A, Pietrobom RFR, Rodrigues DP, Magalhães M, Mimica MJ, Llaguno NS, Leandro DMK, Girotto PN, Sampaio LB, Van Meurs KP
JAMA Netw Open 2023 Nov 1;6(11):e2343429. doi: 10.1001/jamanetworkopen.2023.43429. PMID: 37966836Free PMC Article
Anti-seizure medications for neonates with seizures.
Abiramalatha T, Thanigainathan S, Ramaswamy VV, Pressler R, Brigo F, Hartmann H
Cochrane Database Syst Rev 2023 Oct 24;10(10):CD014967. doi: 10.1002/14651858.CD014967.pub2. PMID: 37873971Free PMC Article
Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.
Pressler RM, Cilio MR, Mizrahi EM, Moshé SL, Nunes ML, Plouin P, Vanhatalo S, Yozawitz E, de Vries LS, Puthenveettil Vinayan K, Triki CC, Wilmshurst JM, Yamamoto H, Zuberi SM
Epilepsia 2021 Mar;62(3):615-628. Epub 2021 Feb 1 doi: 10.1111/epi.16815. PMID: 33522601

Diagnosis

Anti-seizure medications for neonates with seizures.
Abiramalatha T, Thanigainathan S, Ramaswamy VV, Pressler R, Brigo F, Hartmann H
Cochrane Database Syst Rev 2023 Oct 24;10(10):CD014967. doi: 10.1002/14651858.CD014967.pub2. PMID: 37873971Free PMC Article
Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Neonatal Seizures-Perspective in Low-and Middle-Income Countries.
Vegda H, Krishnan V, Variane G, Bagayi V, Ivain P, Pressler RM
Indian J Pediatr 2022 Mar;89(3):245-253. Epub 2022 Jan 20 doi: 10.1007/s12098-021-04039-2. PMID: 35050459Free PMC Article
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.
Pressler RM, Cilio MR, Mizrahi EM, Moshé SL, Nunes ML, Plouin P, Vanhatalo S, Yozawitz E, de Vries LS, Puthenveettil Vinayan K, Triki CC, Wilmshurst JM, Yamamoto H, Zuberi SM
Epilepsia 2021 Mar;62(3):615-628. Epub 2021 Feb 1 doi: 10.1111/epi.16815. PMID: 33522601

Therapy

Anti-seizure medications for neonates with seizures.
Abiramalatha T, Thanigainathan S, Ramaswamy VV, Pressler R, Brigo F, Hartmann H
Cochrane Database Syst Rev 2023 Oct 24;10(10):CD014967. doi: 10.1002/14651858.CD014967.pub2. PMID: 37873971Free PMC Article
Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives.
Donovan MD, Griffin BT, Kharoshankaya L, Cryan JF, Boylan GB
Drugs 2016 Apr;76(6):647-61. doi: 10.1007/s40265-016-0554-7. PMID: 26943929
Occult neonatal seizures.
Clancy RR, Legido A, Lewis D
Epilepsia 1988 May-Jun;29(3):256-61. doi: 10.1111/j.1528-1157.1988.tb03715.x. PMID: 3371282

Prognosis

Clinical and electroencephalography characteristics of 45 patients with neonatal seizures.
Li L, Deng Y, Chen J, Xie L, Lan X, Hu Y, Hong S, Jiang L
Neurophysiol Clin 2023 Feb;53(1):102886. Epub 2023 Jun 7 doi: 10.1016/j.neucli.2023.102886. PMID: 37295040
Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study.
Massey SL, Glass HC, Shellhaas RA, Bonifacio S, Chang T, Chu C, Cilio MR, Lemmon ME, McCulloch CE, Soul JS, Thomas C, Wusthoff CJ, Xiao R, Abend NS
J Pediatr 2022 Mar;242:63-73. Epub 2021 Oct 30 doi: 10.1016/j.jpeds.2021.10.058. PMID: 34728234Free PMC Article
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Symptomatic seizures in preterm newborns: a review on clinical features and prognosis.
Spagnoli C, Falsaperla R, Deolmi M, Corsello G, Pisani F
Ital J Pediatr 2018 Nov 1;44(1):115. doi: 10.1186/s13052-018-0573-y. PMID: 30382869Free PMC Article
Controversies regarding neonatal seizure recognition.
Scher MS
Epileptic Disord 2002 Jun;4(2):139-58. PMID: 12105077

Clinical prediction guides

Temporal evolution of electrographic seizures in newborn infants with hypoxic-ischaemic encephalopathy requiring therapeutic hypothermia: a secondary analysis of the ANSeR studies.
Pavel AM, Rennie JM, de Vries LS, Mathieson SR, Livingstone V, Finder M, Foran A, Shah DK, Pressler RM, Weeke LC, Dempsey EM, Murray DM, Boylan GB; ANSeR Consortium
Lancet Child Adolesc Health 2024 Mar;8(3):214-224. Epub 2024 Jan 18 doi: 10.1016/S2352-4642(23)00296-1. PMID: 38246187Free PMC Article
Remote Monitoring for Seizures During Therapeutic Hypothermia in Neonates With Hypoxic-Ischemic Encephalopathy.
Variane GFT, Dahlen A, Pietrobom RFR, Rodrigues DP, Magalhães M, Mimica MJ, Llaguno NS, Leandro DMK, Girotto PN, Sampaio LB, Van Meurs KP
JAMA Netw Open 2023 Nov 1;6(11):e2343429. doi: 10.1001/jamanetworkopen.2023.43429. PMID: 37966836Free PMC Article
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.
Pavel AM, O'Toole JM, Proietti J, Livingstone V, Mitra S, Marnane WP, Finder M, Dempsey EM, Murray DM, Boylan GB; ANSeR Consortium
Epilepsia 2023 Feb;64(2):456-468. Epub 2022 Dec 20 doi: 10.1111/epi.17468. PMID: 36398397Free PMC Article
Neonatal seizures: When semiology points to etiology.
Santarone ME, Pietrafusa N, Fusco L
Seizure 2020 Aug;80:161-165. Epub 2020 Jun 18 doi: 10.1016/j.seizure.2020.06.025. PMID: 32585613
Controversies regarding neonatal seizure recognition.
Scher MS
Epileptic Disord 2002 Jun;4(2):139-58. PMID: 12105077

Recent systematic reviews

Anti-seizure medications for neonates with seizures.
Abiramalatha T, Thanigainathan S, Ramaswamy VV, Pressler R, Brigo F, Hartmann H
Cochrane Database Syst Rev 2023 Oct 24;10(10):CD014967. doi: 10.1002/14651858.CD014967.pub2. PMID: 37873971Free PMC Article
Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702

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