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Intratubular light-chain casts

MedGen UID:
1711885
•Concept ID:
C5397648
•
Finding
HPO: HP:0032630

Definition

The presence of casts containing immunoglobulin light chains within the lumina of the renal tubules. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntratubular light-chain casts

Recent clinical studies

Etiology

Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis.
Gibier JB, Gnemmi V, Glowacki F, Boyle EM, Lopez B, MacNamara E, Hoffmann M, Azar R, Guincestre T, Bourdon F, Copin MC, Buob D
Mod Pathol 2018 Mar;31(3):452-462. Epub 2017 Oct 20 doi: 10.1038/modpathol.2017.124. PMID: 29052601
Fanconi's syndrome, kappa light-chain myeloma, non-amyloid fibrils and cytoplasmic crystals in renal tubular epithelium.
Orfila C, Lepert JC, Modesto A, Bernadet P, Suc JM
Am J Nephrol 1991;11(4):345-9. doi: 10.1159/000168336. PMID: 1665955

Diagnosis

Unique morphology of intratubular light chain casts in multiple myeloma: the amyloid cast nephropathy.
Sharma A, Bansal S, Jain R
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):629-31. doi: 10.4103/0377-4929.142712. PMID: 25308025

Prognosis

A practical approach to the pathology of renal intratubular casts.
Dvanajscak Z, Cossey LN, Larsen CP
Semin Diagn Pathol 2020 May;37(3):127-134. Epub 2020 Feb 14 doi: 10.1053/j.semdp.2020.02.001. PMID: 32147230
Unusual morphology of amyloid cast nephropathy in renal biopsy portending poor prognosis.
Rajagopal MD, Nachiappa Ganesh R, Parameswaran S, Puthiyottil D
BMJ Case Rep 2018 Dec 22;11(1) doi: 10.1136/bcr-2018-225899. PMID: 30580293Free PMC Article
The pathogenesis of acute kidney impairment in patients with multiple myeloma.
Batuman V
Adv Chronic Kidney Dis 2012 Sep;19(5):282-6. doi: 10.1053/j.ackd.2012.04.009. PMID: 22920637

Clinical prediction guides

Fanconi's syndrome, kappa light-chain myeloma, non-amyloid fibrils and cytoplasmic crystals in renal tubular epithelium.
Orfila C, Lepert JC, Modesto A, Bernadet P, Suc JM
Am J Nephrol 1991;11(4):345-9. doi: 10.1159/000168336. PMID: 1665955

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