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Renal interstitial granulomas

MedGen UID:
1710690
Concept ID:
C5397658
Pathologic Function
Synonym: Renal interstitial granulomata
 
HPO: HP:0032641

Definition

Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present. [from HPO]

Professional guidelines

PubMed

Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L
Eur J Intern Med 2015 Sep;26(7):545-53. Epub 2015 May 9 doi: 10.1016/j.ejim.2015.04.022. PMID: 25971154
Hilderson I, Van Laecke S, Wauters A, Donck J
Nephrol Dial Transplant 2014 Oct;29(10):1841-7. Epub 2013 Nov 13 doi: 10.1093/ndt/gft442. PMID: 24235078

Recent clinical studies

Etiology

Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Sharma A, Nada R, Naidu GS, Minz RW, Kohli HS, Sakhuja V, Gupta KL, Rathi M
Int J Rheum Dis 2016 Jan;19(1):74-81. Epub 2015 Aug 13 doi: 10.1111/1756-185X.12729. PMID: 26269223
Mahévas M, Lescure FX, Boffa JJ, Delastour V, Belenfant X, Chapelon C, Cordonnier C, Makdassi R, Piette JC, Naccache JM, Cadranel J, Duhaut P, Choukroun G, Ducroix JP, Valeyre D
Medicine (Baltimore) 2009 Mar;88(2):98-106. doi: 10.1097/MD.0b013e31819de50f. PMID: 19282700

Diagnosis

Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L
Eur J Intern Med 2015 Sep;26(7):545-53. Epub 2015 May 9 doi: 10.1016/j.ejim.2015.04.022. PMID: 25971154

Therapy

Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Anupama BK, Sampat P, Gambhir HS
J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211001659. doi: 10.1177/23247096211001659. PMID: 33733898Free PMC Article
Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Zhang Y, Ahmed H, Haririan A, Ugarte R, Papadimitriou JC, Drachenberg CB
Transpl Infect Dis 2018 Oct;20(5):e12939. Epub 2018 Jun 22 doi: 10.1111/tid.12939. PMID: 29863293
Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L
Eur J Intern Med 2015 Sep;26(7):545-53. Epub 2015 May 9 doi: 10.1016/j.ejim.2015.04.022. PMID: 25971154

Prognosis

Maiti J, Mathew GG, Jayaprakash V, Sreedhar S
Indian J Pharmacol 2024 Jul 1;56(4):290-292. Epub 2024 Sep 10 doi: 10.4103/ijp.ijp_19_24. PMID: 39250627Free PMC Article
Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Zhang Y, Ahmed H, Haririan A, Ugarte R, Papadimitriou JC, Drachenberg CB
Transpl Infect Dis 2018 Oct;20(5):e12939. Epub 2018 Jun 22 doi: 10.1111/tid.12939. PMID: 29863293

Clinical prediction guides

Maiti J, Mathew GG, Jayaprakash V, Sreedhar S
Indian J Pharmacol 2024 Jul 1;56(4):290-292. Epub 2024 Sep 10 doi: 10.4103/ijp.ijp_19_24. PMID: 39250627Free PMC Article
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Yang S, Chai D, Li Y, Wang Y, Zhan X, Zhang L, Wang J, Ye Q
Clin Rheumatol 2022 Mar;41(3):783-793. Epub 2021 Nov 27 doi: 10.1007/s10067-021-05964-5. PMID: 34839416
Sharma A, Nada R, Naidu GS, Minz RW, Kohli HS, Sakhuja V, Gupta KL, Rathi M
Int J Rheum Dis 2016 Jan;19(1):74-81. Epub 2015 Aug 13 doi: 10.1111/1756-185X.12729. PMID: 26269223
Mahévas M, Lescure FX, Boffa JJ, Delastour V, Belenfant X, Chapelon C, Cordonnier C, Makdassi R, Piette JC, Naccache JM, Cadranel J, Duhaut P, Choukroun G, Ducroix JP, Valeyre D
Medicine (Baltimore) 2009 Mar;88(2):98-106. doi: 10.1097/MD.0b013e31819de50f. PMID: 19282700

Recent systematic reviews

Wang C, Liu H, Zhang T, Xu H, Shen J, Feng J, Sun L
Clin Chim Acta 2019 Feb;489:68-74. Epub 2018 Nov 7 doi: 10.1016/j.cca.2018.11.014. PMID: 30414436

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