U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Renal interstitial granulomas

MedGen UID:
1710690
•Concept ID:
C5397658
•
Pathologic Function
Synonym: Renal interstitial granulomata
 
HPO: HP:0032641

Definition

Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present. [from HPO]

Professional guidelines

PubMed

Renal sarcoidosis: approach to diagnosis and management.
Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management.
Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L
Eur J Intern Med 2015 Sep;26(7):545-53. Epub 2015 May 9 doi: 10.1016/j.ejim.2015.04.022. PMID: 25971154
Treatment of renal sarcoidosis: is there a guideline? Overview of the different treatment options.
Hilderson I, Van Laecke S, Wauters A, Donck J
Nephrol Dial Transplant 2014 Oct;29(10):1841-7. Epub 2013 Nov 13 doi: 10.1093/ndt/gft442. PMID: 24235078

Recent clinical studies

Etiology

Renal sarcoidosis.
Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Scleromyxedema.
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Renal sarcoidosis: approach to diagnosis and management.
Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Pauci-immune glomerulonephritis: does negativity of anti-neutrophilic cytoplasmic antibodies matters?
Sharma A, Nada R, Naidu GS, Minz RW, Kohli HS, Sakhuja V, Gupta KL, Rathi M
Int J Rheum Dis 2016 Jan;19(1):74-81. Epub 2015 Aug 13 doi: 10.1111/1756-185X.12729. PMID: 26269223
Renal sarcoidosis: clinical, laboratory, and histologic presentation and outcome in 47 patients.
Mahévas M, Lescure FX, Boffa JJ, Delastour V, Belenfant X, Chapelon C, Cordonnier C, Makdassi R, Piette JC, Naccache JM, Cadranel J, Duhaut P, Choukroun G, Ducroix JP, Valeyre D
Medicine (Baltimore) 2009 Mar;88(2):98-106. doi: 10.1097/MD.0b013e31819de50f. PMID: 19282700

Diagnosis

Renal sarcoidosis.
Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Renal sarcoidosis.
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Scleromyxedema.
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Renal sarcoidosis: approach to diagnosis and management.
Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management.
Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L
Eur J Intern Med 2015 Sep;26(7):545-53. Epub 2015 May 9 doi: 10.1016/j.ejim.2015.04.022. PMID: 25971154

Therapy

Renal sarcoidosis.
Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Nitrofurantoin-Associated Acute Granulomatous Interstitial Nephritis.
Anupama BK, Sampat P, Gambhir HS
J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211001659. doi: 10.1177/23247096211001659. PMID: 33733898Free PMC Article
Renal sarcoidosis: approach to diagnosis and management.
Bergner R, Löffler C
Curr Opin Pulm Med 2018 Sep;24(5):513-520. doi: 10.1097/MCP.0000000000000504. PMID: 29965860
Granulomatous inflammation in BK polyomavirus-associated nephropathy.
Zhang Y, Ahmed H, Haririan A, Ugarte R, Papadimitriou JC, Drachenberg CB
Transpl Infect Dis 2018 Oct;20(5):e12939. Epub 2018 Jun 22 doi: 10.1111/tid.12939. PMID: 29863293
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management.
Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J, Humbert M, Jayne D, Jennette JC, Lazor R, Mahr A, Merkel PA, Mouthon L, Sinico RA, Specks U, Vaglio A, Wechsler ME, Cordier JF, Guillevin L
Eur J Intern Med 2015 Sep;26(7):545-53. Epub 2015 May 9 doi: 10.1016/j.ejim.2015.04.022. PMID: 25971154

Prognosis

Anti-tubercular treatment-induced granulomatous acute interstitial nephritis.
Maiti J, Mathew GG, Jayaprakash V, Sreedhar S
Indian J Pharmacol 2024 Jul 1;56(4):290-292. Epub 2024 Sep 10 doi: 10.4103/ijp.ijp_19_24. PMID: 39250627Free PMC Article
Renal sarcoidosis.
Mehta S, Lightle A, Judson MA
Nephrol Dial Transplant 2023 Mar 31;38(4):803-810. doi: 10.1093/ndt/gfac219. PMID: 35867874
Renal sarcoidosis.
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Scleromyxedema.
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Granulomatous inflammation in BK polyomavirus-associated nephropathy.
Zhang Y, Ahmed H, Haririan A, Ugarte R, Papadimitriou JC, Drachenberg CB
Transpl Infect Dis 2018 Oct;20(5):e12939. Epub 2018 Jun 22 doi: 10.1111/tid.12939. PMID: 29863293

Clinical prediction guides

Anti-tubercular treatment-induced granulomatous acute interstitial nephritis.
Maiti J, Mathew GG, Jayaprakash V, Sreedhar S
Indian J Pharmacol 2024 Jul 1;56(4):290-292. Epub 2024 Sep 10 doi: 10.4103/ijp.ijp_19_24. PMID: 39250627Free PMC Article
Renal sarcoidosis.
Calatroni M, Moroni G, Reggiani F, Ponticelli C
J Nephrol 2023 Jan;36(1):5-15. Epub 2022 Jun 27 doi: 10.1007/s40620-022-01369-y. PMID: 35761015
Patterns of lung diseases predict survival in patients with MPO-ANCA-associated vasculitis: a single-center retrospective study.
Yang S, Chai D, Li Y, Wang Y, Zhan X, Zhang L, Wang J, Ye Q
Clin Rheumatol 2022 Mar;41(3):783-793. Epub 2021 Nov 27 doi: 10.1007/s10067-021-05964-5. PMID: 34839416
Pauci-immune glomerulonephritis: does negativity of anti-neutrophilic cytoplasmic antibodies matters?
Sharma A, Nada R, Naidu GS, Minz RW, Kohli HS, Sakhuja V, Gupta KL, Rathi M
Int J Rheum Dis 2016 Jan;19(1):74-81. Epub 2015 Aug 13 doi: 10.1111/1756-185X.12729. PMID: 26269223
Renal sarcoidosis: clinical, laboratory, and histologic presentation and outcome in 47 patients.
Mahévas M, Lescure FX, Boffa JJ, Delastour V, Belenfant X, Chapelon C, Cordonnier C, Makdassi R, Piette JC, Naccache JM, Cadranel J, Duhaut P, Choukroun G, Ducroix JP, Valeyre D
Medicine (Baltimore) 2009 Mar;88(2):98-106. doi: 10.1097/MD.0b013e31819de50f. PMID: 19282700

Recent systematic reviews

Acute kidney injury as a rare manifestation of pediatric sarcoidosis: A case report and systematic literature review.
Wang C, Liu H, Zhang T, Xu H, Shen J, Feng J, Sun L
Clin Chim Acta 2019 Feb;489:68-74. Epub 2018 Nov 7 doi: 10.1016/j.cca.2018.11.014. PMID: 30414436

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...