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Recurrent Transformed T-cell Non-Hodgkin Lymphoma

MedGen UID:
1709037
•Concept ID:
C5237460
•
Neoplastic Process

Definition

The reemergence of T-cell non-Hodgkin lymphoma transformed after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Transformed T-cell Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Management of aggressive lymphoma after CAR T-cell therapy failure.
Nastoupil LJ, Kambhampati S
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):364-369. doi: 10.1182/hematology.2023000437. PMID: 38066908Free PMC Article
ABCs of ADCs in management of relapsed/refractory diffuse large B-cell lymphoma.
Alderuccio JP, Sharman JP
Blood Rev 2022 Nov;56:100967. Epub 2022 Apr 22 doi: 10.1016/j.blre.2022.100967. PMID: 35489963
Changing the paradigms of treatment in peripheral T-cell lymphoma: from biology to clinical practice.
O'Connor OA, Bhagat G, Ganapathi K, Pedersen MB, D'Amore F, Radeski D, Bates SE
Clin Cancer Res 2014 Oct 15;20(20):5240-54. doi: 10.1158/1078-0432.CCR-14-2020. PMID: 25320373

Recent clinical studies

Therapy

Blinatumomab consolidation post-autologous stem cell transplantation in patients with diffuse large B-cell lymphoma.
Ghobadi A, Foley NC, Cohen J, Rettig MP, Cashen AF, Gehrs L, Christ S, Street E, Wallace N, Ritchey J, Mehta-Shah N, Westervelt P, Fehniger TA, Kahl B, Bartlett NL, DiPersio JF
Blood Adv 2024 Feb 13;8(3):513-522. doi: 10.1182/bloodadvances.2023011130. PMID: 37871306Free PMC Article
Management of aggressive lymphoma after CAR T-cell therapy failure.
Nastoupil LJ, Kambhampati S
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):364-369. doi: 10.1182/hematology.2023000437. PMID: 38066908Free PMC Article
Richter transformation-is there light at the end of this tunnel?
Eyre TA
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):427-432. doi: 10.1182/hematology.2023000442. PMID: 38066897Free PMC Article
Mosunetuzumab monotherapy is active and tolerable in patients with relapsed/refractory diffuse large B-cell lymphoma.
Bartlett NL, Assouline S, Giri P, Schuster SJ, Cheah CY, Matasar M, Gregory GP, Yoon DH, Shadman M, Fay K, Yoon SS, Panizo C, Flinn I, Johnston A, Bosch F, Sehn LH, Wei MC, Yin S, To I, Li CC, Huang H, Kwan A, Penuel E, Budde LE
Blood Adv 2023 Sep 12;7(17):4926-4935. doi: 10.1182/bloodadvances.2022009260. PMID: 37067952Free PMC Article
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407

Prognosis

Richter transformation-is there light at the end of this tunnel?
Eyre TA
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):427-432. doi: 10.1182/hematology.2023000442. PMID: 38066897Free PMC Article
Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma.
Song X, Chang S, Seminario-Vidal L, de Mingo Pulido A, Tordesillas L, Song X, Reed RA, Harkins A, Whiddon S, Nguyen JV, Segura CM, Zhang C, Yoder S, Sayegh Z, Zhao Y, Messina JL, Harro CM, Zhang X, Conejo-Garcia JR, Berglund A, Sokol L, Zhang J, Rodriguez PC, Mulé JJ, Futreal AP, Tsai KY, Chen PL
Cancer Discov 2022 May 2;12(5):1294-1313. doi: 10.1158/2159-8290.CD-21-1207. PMID: 35247891Free PMC Article
Genetic and epigenetic insights into cutaneous T-cell lymphoma.
Tensen CP, Quint KD, Vermeer MH
Blood 2022 Jan 6;139(1):15-33. doi: 10.1182/blood.2019004256. PMID: 34570882
How we treat mature B-cell neoplasms (indolent B-cell lymphomas).
Lumish M, Falchi L, Imber BS, Scordo M, von Keudell G, Joffe E
J Hematol Oncol 2021 Jan 6;14(1):5. doi: 10.1186/s13045-020-01018-6. PMID: 33407745Free PMC Article
Novel insights into the pathogenesis of T-cell lymphomas.
Van Arnam JS, Lim MS, Elenitoba-Johnson KSJ
Blood 2018 May 24;131(21):2320-2330. Epub 2018 Apr 17 doi: 10.1182/blood-2017-11-764357. PMID: 29666117

Clinical prediction guides

Blinatumomab consolidation post-autologous stem cell transplantation in patients with diffuse large B-cell lymphoma.
Ghobadi A, Foley NC, Cohen J, Rettig MP, Cashen AF, Gehrs L, Christ S, Street E, Wallace N, Ritchey J, Mehta-Shah N, Westervelt P, Fehniger TA, Kahl B, Bartlett NL, DiPersio JF
Blood Adv 2024 Feb 13;8(3):513-522. doi: 10.1182/bloodadvances.2023011130. PMID: 37871306Free PMC Article
Safety and efficacy of tisagenlecleucel in patients with relapsed or refractory B-cell lymphoma: the first real-world evidence in Japan.
Goto H, Kitawaki T, Fujii N, Kato K, Onishi Y, Fukuhara N, Yamauchi T, Toratani K, Kobayashi H, Yoshida S, Shimo M, Onodera K, Senjo H, Onozawa M, Hirata K, Yokota I, Teshima T
Int J Clin Oncol 2023 Jun;28(6):816-826. Epub 2023 Apr 18 doi: 10.1007/s10147-023-02334-w. PMID: 37071252
t(10;12)(q24;q15): A new cytogenetic marker in hematological malignancies.
Bernués M, González T, Corchete LA, Santos S, Durán MA, López-Andrade B, Riso LL, Martínez-Serra J, Ramos R, Iglesias J, Royo I, Rosell J
Cancer Genet 2022 Jun;264-265:60-65. Epub 2022 Mar 26 doi: 10.1016/j.cancergen.2022.03.004. PMID: 35397254
Mechanisms of and approaches to overcoming resistance to immunotherapy.
Schultz L, Gardner R
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):226-232. doi: 10.1182/hematology.2019000018. PMID: 31808880Free PMC Article
Mycosis Fungoides: A 10-year Turkish Experience.
Baykal Selcuk L, Aksu Arica D, Yayli S, Seyman Ü, Bahadir S
Acta Dermatovenerol Croat 2019 Sep;27(3):153-158. PMID: 31542058

Recent systematic reviews

A systematic review and meta-analysis of CD22 CAR T-cells alone or in combination with CD19 CAR T-cells.
Fergusson NJ, Adeel K, Kekre N, Atkins H, Hay KA
Front Immunol 2023;14:1178403. Epub 2023 Apr 27 doi: 10.3389/fimmu.2023.1178403. PMID: 37180149Free PMC Article
Chimeric antigen receptor T-cell therapy in adults with B-cell acute lymphoblastic leukemia.
Grover P, Veilleux O, Tian L, Sun R, Previtera M, Curran E, Muffly L
Blood Adv 2022 Mar 8;6(5):1608-1618. doi: 10.1182/bloodadvances.2020003482. PMID: 34610109Free PMC Article

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