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Renal tubular epithelial cell hyaline droplets

MedGen UID:: 1708809
•Concept ID:: C5397622
•: Cell or Molecular Dysfunction

HPO:	HP:0032600

Definition

Tubular epithelium with round strongly PAS-positive cytoplasmic droplet material in at least one tubular epithelial cell. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRenal tubular epithelial cell hyaline droplets

Abnormality of the upper urinary tract
- Abnormality of the kidney
  - Abnormal renal morphology
    - Abnormal nephron morphology
      - Abnormal renal tubule morphology
        Abnormal renal tubular epithelial morphology
        Renal tubular epithelial cell hyaline droplets

Recent clinical studies

Etiology

An alternative hypothesis on the role of chemically induced protein droplet (alpha 2u-globulin) nephropathy in renal carcinogenesis.

Melnick RL
Regul Toxicol Pharmacol 1992 Oct;16(2):111-25. doi: 10.1016/0273-2300(92)90052-b. PMID: 1279759

Clinical prediction guides

Occurrence of hyaline droplets in renal biopsy specimens: an ultrastructural study.

Sato S, Kitamura H, Ghazizadeh M, Adachi A, Sasaki Y, Ishizaki M, Inoue K, Wakamatsu K, Sugisaki Y
Med Mol Morphol 2005 Mar;38(1):63-71. doi: 10.1007/s00795-004-0272-1. PMID: 16158182

Role of lipids in the progression of renal disease in systemic lupus erythematosus patients.

Luzar B, Ferluga D
Wien Klin Wochenschr 2000 Aug 25;112(15-16):716-21. PMID: 11020963

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