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Unresectable Rectal Adenocarcinoma

MedGen UID:
1707346
•Concept ID:
C5206342
•
Neoplastic Process

Definition

A rectal adenocarcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Rectal Adenocarcinoma

Professional guidelines

PubMed

Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

Recent clinical studies

Etiology

Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival?
Mawdsley S, Glynne-Jones R, Grainger J, Richman P, Makris A, Harrison M, Ashford R, Harrison RA, Osborne M, Livingstone JI, MacDonald P, Mitchell IC, Meyrick-Thomas J, Northover JM, Windsor A, Novell R, Wallace M
Int J Radiat Oncol Biol Phys 2005 Nov 1;63(3):745-52. doi: 10.1016/j.ijrobp.2005.03.003. PMID: 16199310
Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995
Preoperative irradiation and surgery for initially unresectable adenocarcinoma of the rectum.
Mendenhall WM, Souba WW, Bland KI, Million RR, Copeland EM 3rd
Am Surg 1992 Jul;58(7):423-9. PMID: 1616188
Initially unresectable rectal adenocarcinoma treated with preoperative irradiation and surgery.
Mendenhall WM, Million RR, Bland KI, Pfaff WW, Copeland EM 3rd
Ann Surg 1987 Jan;205(1):41-4. doi: 10.1097/00000658-198701000-00007. PMID: 3800461Free PMC Article

Therapy

Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival?
Mawdsley S, Glynne-Jones R, Grainger J, Richman P, Makris A, Harrison M, Ashford R, Harrison RA, Osborne M, Livingstone JI, MacDonald P, Mitchell IC, Meyrick-Thomas J, Northover JM, Windsor A, Novell R, Wallace M
Int J Radiat Oncol Biol Phys 2005 Nov 1;63(3):745-52. doi: 10.1016/j.ijrobp.2005.03.003. PMID: 16199310
Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

Prognosis

Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival?
Mawdsley S, Glynne-Jones R, Grainger J, Richman P, Makris A, Harrison M, Ashford R, Harrison RA, Osborne M, Livingstone JI, MacDonald P, Mitchell IC, Meyrick-Thomas J, Northover JM, Windsor A, Novell R, Wallace M
Int J Radiat Oncol Biol Phys 2005 Nov 1;63(3):745-52. doi: 10.1016/j.ijrobp.2005.03.003. PMID: 16199310
Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995
Preoperative irradiation and surgery for initially unresectable adenocarcinoma of the rectum.
Mendenhall WM, Souba WW, Bland KI, Million RR, Copeland EM 3rd
Am Surg 1992 Jul;58(7):423-9. PMID: 1616188
Initially unresectable rectal adenocarcinoma treated with preoperative irradiation and surgery.
Mendenhall WM, Million RR, Bland KI, Pfaff WW, Copeland EM 3rd
Ann Surg 1987 Jan;205(1):41-4. doi: 10.1097/00000658-198701000-00007. PMID: 3800461Free PMC Article

Clinical prediction guides

Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival?
Mawdsley S, Glynne-Jones R, Grainger J, Richman P, Makris A, Harrison M, Ashford R, Harrison RA, Osborne M, Livingstone JI, MacDonald P, Mitchell IC, Meyrick-Thomas J, Northover JM, Windsor A, Novell R, Wallace M
Int J Radiat Oncol Biol Phys 2005 Nov 1;63(3):745-52. doi: 10.1016/j.ijrobp.2005.03.003. PMID: 16199310
Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy.
Marsh RD, Chu NM, Vauthey JN, Mendenhall WM, Lauwers GY, Bewsher C, Copeland EM
Cancer 1996 Jul 15;78(2):217-25. doi: 10.1002/(SICI)1097-0142(19960715)78:2<217::AID-CNCR5>3.0.CO;2-I. PMID: 8673995

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