Warning: The NCBI web site requires JavaScript to function. more...

Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Neutrophil nuclear clefts

MedGen UID:: 1705120
•Concept ID:: C5209289
•: Finding

HPO:	HP:0041043

Definition

An abnormality of the nucleus of neutrophils, which presents as either a type I nuclear cleft, where the nuclear cleft may show a transition into a round/oval shape. The second type nuclear cleft, which runs perpendicular to the nuclear surface, and this type of cleft might be related to nuclear lobe formation. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeutrophil nuclear clefts

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormal nervous system morphology
    - Morphological central nervous system abnormality
      - Abnormal cerebrospinal fluid morphology
        Abnormality of neutrophil morphology in CSF
        Neutrophil nuclear clefts

Conditions with this feature

Specific granule deficiency 1

MedGen UID:: 1644049
•Concept ID:: C4551556
•: Disease or Syndrome

Any specific granule deficiency in which the cause of the disease is a mutation in the CEBPE gene.

See: Condition Record

Specific granule deficiency 1

Recent clinical studies

Etiology

Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils.

Khayyata S, Basturk O, Adsay NV
Mod Pathol 2005 Nov;18(11):1504-11. doi: 10.1038/modpathol.3800460. PMID: 16007065

Mollaret's meningitis: cytopathologic analysis of fourteen cases.

Chan TY, Parwani AV, Levi AW, Ali SZ
Diagn Cytopathol 2003 May;28(5):227-31. doi: 10.1002/dc.10261. PMID: 12722116

Diagnosis

Mollaret's meningitis: cytopathologic analysis of fourteen cases.

Chan TY, Parwani AV, Levi AW, Ali SZ
Diagn Cytopathol 2003 May;28(5):227-31. doi: 10.1002/dc.10261. PMID: 12722116

Therapy

Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.

Donaldson GL, Bury RG
Acta Paediatr Scand 1982 Mar;71(2):335-8. doi: 10.1111/j.1651-2227.1982.tb09428.x. PMID: 7136644

Prognosis

Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils.

Khayyata S, Basturk O, Adsay NV
Mod Pathol 2005 Nov;18(11):1504-11. doi: 10.1038/modpathol.3800460. PMID: 16007065

Clinical prediction guides

Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils.

Khayyata S, Basturk O, Adsay NV
Mod Pathol 2005 Nov;18(11):1504-11. doi: 10.1038/modpathol.3800460. PMID: 16007065

Supplemental Content

Table of contents

Clinical resources

ClinicalTrials.gov

Consumer resources

MedlinePlus

Reviews

Related information

PubMed
Related literature resources in PubMed

Recent activity

Clear Turn Off Turn On

Neutrophil nuclear clefts
Neutrophil nuclear clefts

MedGen
Elevated CSF 5-amino-4-imidazolecarboxyamide concentration
Elevated CSF 5-amino-4-imidazolecarboxyamide concentration

MedGen
Abnormal amyloid beta 40 peptide CSF concentration
Abnormal amyloid beta 40 peptide CSF concentration

MedGen
Decreased CSF N-acetyl-aspartyl-glutamate concentration
Decreased CSF N-acetyl-aspartyl-glutamate concentration

MedGen
Profile neighbors for GEO Profiles (Select 82338595) (184)
GEO Profiles

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...