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Decreased high-mannose N-glycan level

MedGen UID:
1704745
Concept ID:
C5139523
Finding
Synonym: Decreased high-mannose N-glycans on glycoprotein concentration
 
HPO: HP:0410358

Definition

An abnormal decrease in the concentration of high-mannose N-glycans on glycoproteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased high-mannose N-glycan level

Recent clinical studies

Etiology

Fan J, Sha J, Chang S, Zhao H, Niu X, Gu Y, Gu J, Ren S
Aging Cell 2023 Jul;22(7):e13855. Epub 2023 May 2 doi: 10.1111/acel.13855. PMID: 37132100Free PMC Article
Rudman N, Kifer D, Kaur S, Simunović V, Cvetko A, Pociot F, Morahan G, Gornik O
Diabetologia 2022 Aug;65(8):1315-1327. Epub 2022 May 27 doi: 10.1007/s00125-022-05703-8. PMID: 35622127Free PMC Article
Trbojević-Akmačić I, Vučković F, Vilaj M, Skelin A, Karssen LC, Krištić J, Jurić J, Momčilović A, Šimunović J, Mangino M, De Gregori M, Marchesini M, Dagostino C, Štambuk J, Novokmet M, Rauck R, Aulchenko YS, Primorac D, Kapural L, Buyse K, Mesotten D, Williams FMK, van Zundert J, Allegri M, Lauc G
Biochim Biophys Acta Gen Subj 2018 Oct;1862(10):2124-2133. Epub 2018 Jul 5 doi: 10.1016/j.bbagen.2018.07.003. PMID: 29981899

Diagnosis

Rudman N, Kifer D, Kaur S, Simunović V, Cvetko A, Pociot F, Morahan G, Gornik O
Diabetologia 2022 Aug;65(8):1315-1327. Epub 2022 May 27 doi: 10.1007/s00125-022-05703-8. PMID: 35622127Free PMC Article
Trbojević-Akmačić I, Vučković F, Vilaj M, Skelin A, Karssen LC, Krištić J, Jurić J, Momčilović A, Šimunović J, Mangino M, De Gregori M, Marchesini M, Dagostino C, Štambuk J, Novokmet M, Rauck R, Aulchenko YS, Primorac D, Kapural L, Buyse K, Mesotten D, Williams FMK, van Zundert J, Allegri M, Lauc G
Biochim Biophys Acta Gen Subj 2018 Oct;1862(10):2124-2133. Epub 2018 Jul 5 doi: 10.1016/j.bbagen.2018.07.003. PMID: 29981899
Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E; IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M
Gastroenterology 2018 Sep;155(3):829-843. Epub 2018 May 21 doi: 10.1053/j.gastro.2018.05.030. PMID: 29792883
Jin ZC, Kitajima T, Dong W, Huang YF, Ren WW, Guan F, Chiba Y, Gao XD, Fujita M
J Biol Chem 2018 Apr 13;293(15):5572-5584. Epub 2018 Feb 23 doi: 10.1074/jbc.M117.813030. PMID: 29475941Free PMC Article
Hong PW, Nguyen S, Young S, Su SV, Lee B
J Virol 2007 Aug;81(15):8325-36. Epub 2007 May 23 doi: 10.1128/JVI.01765-06. PMID: 17522223Free PMC Article

Prognosis

Rudman N, Kifer D, Kaur S, Simunović V, Cvetko A, Pociot F, Morahan G, Gornik O
Diabetologia 2022 Aug;65(8):1315-1327. Epub 2022 May 27 doi: 10.1007/s00125-022-05703-8. PMID: 35622127Free PMC Article
Heijs B, Holst-Bernal S, de Graaff MA, Briaire-de Bruijn IH, Rodriguez-Girondo M, van de Sande MAJ, Wuhrer M, McDonnell LA, Bovée JVMG
Lab Invest 2020 Sep;100(9):1252-1261. Epub 2020 Apr 27 doi: 10.1038/s41374-020-0435-2. PMID: 32341520
Trbojević-Akmačić I, Vučković F, Vilaj M, Skelin A, Karssen LC, Krištić J, Jurić J, Momčilović A, Šimunović J, Mangino M, De Gregori M, Marchesini M, Dagostino C, Štambuk J, Novokmet M, Rauck R, Aulchenko YS, Primorac D, Kapural L, Buyse K, Mesotten D, Williams FMK, van Zundert J, Allegri M, Lauc G
Biochim Biophys Acta Gen Subj 2018 Oct;1862(10):2124-2133. Epub 2018 Jul 5 doi: 10.1016/j.bbagen.2018.07.003. PMID: 29981899
Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E; IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M
Gastroenterology 2018 Sep;155(3):829-843. Epub 2018 May 21 doi: 10.1053/j.gastro.2018.05.030. PMID: 29792883

Clinical prediction guides

Harada K, Sho R, Takakura H, Yokoyama E, Koyama R, Yamamoto Y, Adachi N, Tanaka S, Hide I, Sakai N
Biochem Biophys Res Commun 2023 Jun 25;662:58-65. Epub 2023 Apr 14 doi: 10.1016/j.bbrc.2023.04.028. PMID: 37099811
Rudman N, Kifer D, Kaur S, Simunović V, Cvetko A, Pociot F, Morahan G, Gornik O
Diabetologia 2022 Aug;65(8):1315-1327. Epub 2022 May 27 doi: 10.1007/s00125-022-05703-8. PMID: 35622127Free PMC Article
Heijs B, Holst-Bernal S, de Graaff MA, Briaire-de Bruijn IH, Rodriguez-Girondo M, van de Sande MAJ, Wuhrer M, McDonnell LA, Bovée JVMG
Lab Invest 2020 Sep;100(9):1252-1261. Epub 2020 Apr 27 doi: 10.1038/s41374-020-0435-2. PMID: 32341520
Trbojević-Akmačić I, Vučković F, Vilaj M, Skelin A, Karssen LC, Krištić J, Jurić J, Momčilović A, Šimunović J, Mangino M, De Gregori M, Marchesini M, Dagostino C, Štambuk J, Novokmet M, Rauck R, Aulchenko YS, Primorac D, Kapural L, Buyse K, Mesotten D, Williams FMK, van Zundert J, Allegri M, Lauc G
Biochim Biophys Acta Gen Subj 2018 Oct;1862(10):2124-2133. Epub 2018 Jul 5 doi: 10.1016/j.bbagen.2018.07.003. PMID: 29981899
Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E; IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M
Gastroenterology 2018 Sep;155(3):829-843. Epub 2018 May 21 doi: 10.1053/j.gastro.2018.05.030. PMID: 29792883

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