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Abnormal tissue metabolite concentration

MedGen UID:
1704511
Concept ID:
C5139219
Finding
HPO: HP:0032243

Definition

Any deviation from the normal concentration of a metabolite in a tissue. [from HPO]

Professional guidelines

PubMed

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Pawlak K, Tankiewicz J, Mysliwiec M, Pawlak D
Blood Coagul Fibrinolysis 2009 Oct;20(7):590-4. doi: 10.1097/MBC.0b013e32832da16d. PMID: 19491664
Drezner MK, Lyles KW, Haussler MR, Harrelson JM
J Clin Invest 1980 Nov;66(5):1020-32. doi: 10.1172/JCI109930. PMID: 6253520Free PMC Article

Recent clinical studies

Etiology

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Kožich V, Stabler S
J Nutr 2020 Oct 1;150(Suppl 1):2506S-2517S. doi: 10.1093/jn/nxaa134. PMID: 33000152
Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M
PLoS Med 2018 Jan;15(1):e1002482. Epub 2018 Jan 25 doi: 10.1371/journal.pmed.1002482. PMID: 29370177Free PMC Article
Bloomgarden Z
J Diabetes 2018 May;10(5):350-352. Epub 2018 Feb 13 doi: 10.1111/1753-0407.12645. PMID: 29369529
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Diagnosis

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M
PLoS Med 2018 Jan;15(1):e1002482. Epub 2018 Jan 25 doi: 10.1371/journal.pmed.1002482. PMID: 29370177Free PMC Article
Bloomgarden Z
J Diabetes 2018 May;10(5):350-352. Epub 2018 Feb 13 doi: 10.1111/1753-0407.12645. PMID: 29369529
Güemes M, Rahman SA, Hussain K
Arch Dis Child 2016 Jun;101(6):569-574. Epub 2015 Sep 14 doi: 10.1136/archdischild-2015-308336. PMID: 26369574
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Therapy

Bloomgarden Z
J Diabetes 2018 May;10(5):350-352. Epub 2018 Feb 13 doi: 10.1111/1753-0407.12645. PMID: 29369529
Traber MG
Adv Nutr 2014 Sep;5(5):503-14. doi: 10.3945/an.114.006254. PMID: 25469382Free PMC Article
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408
Cañete R, Gil-Campos M, Aguilera CM, Gil A
Eur J Nutr 2007 Jun;46(4):181-7. Epub 2007 Mar 26 doi: 10.1007/s00394-007-0648-9. PMID: 17387444
Stanley CA
Ann N Y Acad Sci 2004 Nov;1033:42-51. doi: 10.1196/annals.1320.004. PMID: 15591002

Prognosis

Brown AR, Green JM, Moreman J, Gunnarsson LM, Mourabit S, Ball J, Winter MJ, Trznadel M, Correia A, Hacker C, Perry A, Wood ME, Hetheridge MJ, Currie RA, Tyler CR
Environ Sci Technol 2019 Jan 2;53(1):463-474. Epub 2018 Dec 20 doi: 10.1021/acs.est.8b04281. PMID: 30520632Free PMC Article
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854
Russell RM
Am J Clin Nutr 2000 Apr;71(4):878-84. doi: 10.1093/ajcn/71.4.878. PMID: 10731492
Bottomley PA
Radiology 1994 Jun;191(3):593-612. doi: 10.1148/radiology.191.3.8184033. PMID: 8184033
Wyatt JS, Edwards AD, Azzopardi D, Reynolds EO
Arch Dis Child 1989 Jul;64(7 Spec No):953-63. doi: 10.1136/adc.64.7_spec_no.953. PMID: 2673061Free PMC Article

Clinical prediction guides

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M
PLoS Med 2018 Jan;15(1):e1002482. Epub 2018 Jan 25 doi: 10.1371/journal.pmed.1002482. PMID: 29370177Free PMC Article
Bloomgarden Z
J Diabetes 2018 May;10(5):350-352. Epub 2018 Feb 13 doi: 10.1111/1753-0407.12645. PMID: 29369529
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Recent systematic reviews

Skorobogatov K, De Picker L, Verkerk R, Coppens V, Leboyer M, Müller N, Morrens M
Front Immunol 2021;12:716980. Epub 2021 Sep 23 doi: 10.3389/fimmu.2021.716980. PMID: 34630391Free PMC Article
Clarke CE, Lowry M
Eur J Neurol 2001 Nov;8(6):573-7. doi: 10.1046/j.1468-1331.2001.00308.x. PMID: 11784341

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