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Decreased complex N-glycan level

MedGen UID:
1700906
Concept ID:
C5139518
Finding
Synonym: Increased truncated complex N-glycans on glycoproteins
 
HPO: HP:0410353

Definition

An abnormal decrease in the concentration of complex N-glycans on glycoproteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased complex N-glycan level

Recent clinical studies

Etiology

Levink IJM, Klatte DCF, Hanna-Sawires RG, Vreeker GCM, Ibrahim IS, van der Burgt YEM, Overbeek KA, Koopmann BDM, Cahen DL, Fuhler GM, Wuhrer M, Bonsing BA, Tollenaar RAEM, Vleggaar FP, Vasen HFA, van Leerdam ME, Bruno MJ, Mesker WE
Pancreatology 2022 May;22(4):497-506. Epub 2022 Apr 4 doi: 10.1016/j.pan.2022.03.021. PMID: 35414481
Park JH, Mealer RG, Elias AF, Hoffmann S, Grüneberg M, Biskup S, Fobker M, Haven J, Mangels U, Reunert J, Rust S, Schoof J, Schwanke C, Smoller JW, Cummings RD, Marquardt T
J Inherit Metab Dis 2020 Nov;43(6):1370-1381. Epub 2020 Sep 14 doi: 10.1002/jimd.12306. PMID: 32852845Free PMC Article
Komaromy A, Reider B, Jarvas G, Guttman A
Clin Chim Acta 2020 Jul;506:204-213. Epub 2020 Mar 31 doi: 10.1016/j.cca.2020.03.041. PMID: 32243984
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Menni C, Gudelj I, Macdonald-Dunlop E, Mangino M, Zierer J, Bešić E, Joshi PK, Trbojević-Akmačić I, Chowienczyk PJ, Spector TD, Wilson JF, Lauc G, Valdes AM
Circ Res 2018 May 25;122(11):1555-1564. Epub 2018 Mar 13 doi: 10.1161/CIRCRESAHA.117.312174. PMID: 29535164Free PMC Article

Diagnosis

Wallace EN, West CA, McDowell CT, Lu X, Bruner E, Mehta AS, Aoki-Kinoshita KF, Angel PM, Drake RR
Sci Rep 2024 Jan 4;14(1):489. doi: 10.1038/s41598-023-50957-w. PMID: 38177192Free PMC Article
Beimdiek J, Janciauskiene S, Wrenger S, Volland S, Rozy A, Fuge J, Olejnicka B, Pink I, Illig T, Popov A, Chorostowska J, Buettner FFR, Welte T
Respir Res 2022 Dec 13;23(1):343. doi: 10.1186/s12931-022-02272-7. PMID: 36514048Free PMC Article
Komaromy A, Reider B, Jarvas G, Guttman A
Clin Chim Acta 2020 Jul;506:204-213. Epub 2020 Mar 31 doi: 10.1016/j.cca.2020.03.041. PMID: 32243984
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E; IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M
Gastroenterology 2018 Sep;155(3):829-843. Epub 2018 May 21 doi: 10.1053/j.gastro.2018.05.030. PMID: 29792883

Therapy

Zhang Y, Fan C, Zhang L, Ma X
Prog Mol Biol Transl Sci 2019;163:471-485. Epub 2019 Mar 25 doi: 10.1016/bs.pmbts.2019.03.004. PMID: 31030759

Prognosis

Pérez AG, Andrade-Da-Costa J, De Souza WF, De Souza Ferreira M, Boroni M, De Oliveira IM, Freire-Neto CA, Fernandes PV, De Lanna CA, Souza-Santos PT, Morgado-Díaz JA, De-Freitas-Junior JCM
Oncol Rep 2020 Oct;44(4):1649-1661. Epub 2020 Aug 11 doi: 10.3892/or.2020.7727. PMID: 32945502Free PMC Article
Heijs B, Holst-Bernal S, de Graaff MA, Briaire-de Bruijn IH, Rodriguez-Girondo M, van de Sande MAJ, Wuhrer M, McDonnell LA, Bovée JVMG
Lab Invest 2020 Sep;100(9):1252-1261. Epub 2020 Apr 27 doi: 10.1038/s41374-020-0435-2. PMID: 32341520
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E; IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M
Gastroenterology 2018 Sep;155(3):829-843. Epub 2018 May 21 doi: 10.1053/j.gastro.2018.05.030. PMID: 29792883
Vaiana CA, Kurcon T, Mahal LK
J Biol Chem 2016 Jan 15;291(3):1529-37. Epub 2015 Nov 20 doi: 10.1074/jbc.M115.672220. PMID: 26589799Free PMC Article

Clinical prediction guides

Cogez V, Vicogne D, Schulz C, Portier L, Venturi G, de Ruyck J, Decloquement M, Lensink MF, Brysbaert G, Dall'Olio F, Groux-Degroote S, Harduin-Lepers A
Int J Mol Sci 2023 Feb 18;24(4) doi: 10.3390/ijms24044139. PMID: 36835549Free PMC Article
Pérez AG, Andrade-Da-Costa J, De Souza WF, De Souza Ferreira M, Boroni M, De Oliveira IM, Freire-Neto CA, Fernandes PV, De Lanna CA, Souza-Santos PT, Morgado-Díaz JA, De-Freitas-Junior JCM
Oncol Rep 2020 Oct;44(4):1649-1661. Epub 2020 Aug 11 doi: 10.3892/or.2020.7727. PMID: 32945502Free PMC Article
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E; IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M
Gastroenterology 2018 Sep;155(3):829-843. Epub 2018 May 21 doi: 10.1053/j.gastro.2018.05.030. PMID: 29792883
Welti M, Hülsmeier AJ
J Cell Biochem 2014 Apr;115(4):754-62. doi: 10.1002/jcb.24713. PMID: 24243557

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