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Increased urinary 1-methylhistidine

MedGen UID:
1695240
•Concept ID:
C5139477
•
Finding
Synonym: 1-Methylhistidinuria
 
HPO: HP:0410315

Definition

Increased concentration of 1-methylhistidine in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urinary 1-methylhistidine

Recent clinical studies

Etiology

Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers.
van Breda SG, Mathijs K, Sági-Kiss V, Kuhnle GG, van der Veer B, Jones RR, Sinha R, Ward MH, de Kok TM
Environ Health 2019 Oct 17;18(1):87. doi: 10.1186/s12940-019-0525-z. PMID: 31623611Free PMC Article
Urinary 1-methylhistidine and 3-methylhistidine, meat intake, and colorectal adenoma risk.
Cross AJ, Major JM, Rothman N, Sinha R
Eur J Cancer Prev 2014 Sep;23(5):385-90. doi: 10.1097/CEJ.0000000000000027. PMID: 24681531Free PMC Article
Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies.
Zhang H, Ding L, Fang X, Shi Z, Zhang Y, Chen H, Yan X, Dai J
PLoS One 2011;6(6):e20862. Epub 2011 Jun 3 doi: 10.1371/journal.pone.0020862. PMID: 21677784Free PMC Article
Urinary biomarkers of meat consumption.
Cross AJ, Major JM, Sinha R
Cancer Epidemiol Biomarkers Prev 2011 Jun;20(6):1107-11. Epub 2011 Apr 28 doi: 10.1158/1055-9965.EPI-11-0048. PMID: 21527577Free PMC Article
Analysis of 1- and 3-methylhistidines, aromatic and basic amino acids in rat and human urine.
Feldhoff RC, Ledden DJ, Steffen MC, Steffen JM, Musacchia XJ
J Chromatogr 1984 Nov 28;311(2):267-76. doi: 10.1016/s0378-4347(00)84720-9. PMID: 6520174

Diagnosis

Urinary 1-methylhistidine and 3-methylhistidine, meat intake, and colorectal adenoma risk.
Cross AJ, Major JM, Rothman N, Sinha R
Eur J Cancer Prev 2014 Sep;23(5):385-90. doi: 10.1097/CEJ.0000000000000027. PMID: 24681531Free PMC Article
Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods.
Lloyd AJ, Favé G, Beckmann M, Lin W, Tailliart K, Xie L, Mathers JC, Draper J
Am J Clin Nutr 2011 Oct;94(4):981-91. Epub 2011 Aug 24 doi: 10.3945/ajcn.111.017921. PMID: 21865330
Urinary biomarkers of meat consumption.
Cross AJ, Major JM, Sinha R
Cancer Epidemiol Biomarkers Prev 2011 Jun;20(6):1107-11. Epub 2011 Apr 28 doi: 10.1158/1055-9965.EPI-11-0048. PMID: 21527577Free PMC Article

Therapy

Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers.
van Breda SG, Mathijs K, Sági-Kiss V, Kuhnle GG, van der Veer B, Jones RR, Sinha R, Ward MH, de Kok TM
Environ Health 2019 Oct 17;18(1):87. doi: 10.1186/s12940-019-0525-z. PMID: 31623611Free PMC Article
Urinary 1-methylhistidine and 3-methylhistidine, meat intake, and colorectal adenoma risk.
Cross AJ, Major JM, Rothman N, Sinha R
Eur J Cancer Prev 2014 Sep;23(5):385-90. doi: 10.1097/CEJ.0000000000000027. PMID: 24681531Free PMC Article
Urinary biomarkers of meat consumption.
Cross AJ, Major JM, Sinha R
Cancer Epidemiol Biomarkers Prev 2011 Jun;20(6):1107-11. Epub 2011 Apr 28 doi: 10.1158/1055-9965.EPI-11-0048. PMID: 21527577Free PMC Article
Urinary excretion of acid-soluble peptides in children with Duchenne muscular dystrophy.
Hirano K, Sakamoto Y
Acta Paediatr Jpn 1994 Dec;36(6):627-31. doi: 10.1111/j.1442-200x.1994.tb03258.x. PMID: 7871971

Prognosis

Urinary 1-methylhistidine and 3-methylhistidine, meat intake, and colorectal adenoma risk.
Cross AJ, Major JM, Rothman N, Sinha R
Eur J Cancer Prev 2014 Sep;23(5):385-90. doi: 10.1097/CEJ.0000000000000027. PMID: 24681531Free PMC Article

Clinical prediction guides

Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies.
Zhang H, Ding L, Fang X, Shi Z, Zhang Y, Chen H, Yan X, Dai J
PLoS One 2011;6(6):e20862. Epub 2011 Jun 3 doi: 10.1371/journal.pone.0020862. PMID: 21677784Free PMC Article
Urinary biomarkers of meat consumption.
Cross AJ, Major JM, Sinha R
Cancer Epidemiol Biomarkers Prev 2011 Jun;20(6):1107-11. Epub 2011 Apr 28 doi: 10.1158/1055-9965.EPI-11-0048. PMID: 21527577Free PMC Article
Urinary excretion of acid-soluble peptides in children with Duchenne muscular dystrophy.
Hirano K, Sakamoto Y
Acta Paediatr Jpn 1994 Dec;36(6):627-31. doi: 10.1111/j.1442-200x.1994.tb03258.x. PMID: 7871971

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