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Unresectable Gastric Carcinoma

MedGen UID:
1693015
•Concept ID:
C5204698
•
Neoplastic Process

Definition

A gastric carcinoma that is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Combined modality of radiation and chemotherapy for the treatment of gastric carcinoma. A review.
Queisser W, Heim ME
Onkologie 1989 Aug;12(4):156-60. doi: 10.1159/000216630. PMID: 2677873

Recent clinical studies

Etiology

Direct percutaneous jejunostomy--an underutilized interventional technique?
Sparrow P, David E, Pugash R
Cardiovasc Intervent Radiol 2008 Mar-Apr;31(2):336-41. Epub 2007 Oct 18 doi: 10.1007/s00270-007-9199-y. PMID: 17943346
Expression of p53 protein and resistance to preoperative chemotherapy in locally advanced gastric carcinoma.
Cascinu S, Graziano F, Del Ferro E, Staccioli MP, Ligi M, Carnevali A, Muretto P, Catalano G
Cancer 1998 Nov 1;83(9):1917-22. PMID: 9806649
Stomach-partitioning gastrojejunostomy for unresectable gastric carcinoma.
Kaminishi M, Yamaguchi H, Shimizu N, Nomura S, Yoshikawa A, Hashimoto M, Sakai S, Oohara T
Arch Surg 1997 Feb;132(2):184-7. doi: 10.1001/archsurg.1997.01430260082018. PMID: 9041924
Combined modality of radiation and chemotherapy for the treatment of gastric carcinoma. A review.
Queisser W, Heim ME
Onkologie 1989 Aug;12(4):156-60. doi: 10.1159/000216630. PMID: 2677873
Current management of advanced and locally unresectable gastric carcinoma.
Schein PS, Smith FP, Woolley PV, Ahlgren JD
Cancer 1982 Dec 1;50(11 Suppl):2590-6. PMID: 6754066

Diagnosis

Direct percutaneous jejunostomy--an underutilized interventional technique?
Sparrow P, David E, Pugash R
Cardiovasc Intervent Radiol 2008 Mar-Apr;31(2):336-41. Epub 2007 Oct 18 doi: 10.1007/s00270-007-9199-y. PMID: 17943346
Preclinical evaluation of therapeutic effects of targeted cytotoxic analogs of somatostatin and bombesin on human gastric carcinomas.
Szepeshazi K, Schally AV, Nagy A, Wagner BW, Bajo AM, Halmos G
Cancer 2003 Oct 1;98(7):1401-10. doi: 10.1002/cncr.11649. PMID: 14508826
Immunohistochemical expression of vascular endothelial growth factor can predict response to 5-fluorouracil and cisplatin in patients with gastric adenocarcinoma.
Takiuchi H, Hirata I, Kawabe S, Egashira Y, Katsu K
Oncol Rep 2000 Jul-Aug;7(4):841-6. doi: 10.3892/or.7.4.841. PMID: 10854555
Stomach-partitioning gastrojejunostomy for unresectable gastric carcinoma.
Kaminishi M, Yamaguchi H, Shimizu N, Nomura S, Yoshikawa A, Hashimoto M, Sakai S, Oohara T
Arch Surg 1997 Feb;132(2):184-7. doi: 10.1001/archsurg.1997.01430260082018. PMID: 9041924
Potentially resectable gastric carcinoma: current approaches to staging and preoperative therapy.
Ajani JA, Mansfield PF, Ota DM
World J Surg 1995 Mar-Apr;19(2):216-20. doi: 10.1007/BF00308629. PMID: 7754626

Therapy

Role of radiation therapy in gastric adenocarcinoma.
Hazard L, O'Connor J, Scaife C
World J Gastroenterol 2006 Mar 14;12(10):1511-20. doi: 10.3748/wjg.v12.i10.1511. PMID: 16570342Free PMC Article
Potentially resectable gastric carcinoma: current approaches to staging and preoperative therapy.
Ajani JA, Mansfield PF, Ota DM
World J Surg 1995 Mar-Apr;19(2):216-20. doi: 10.1007/BF00308629. PMID: 7754626
Preoperative and postoperative combination chemotherapy for potentially resectable gastric carcinoma.
Ajani JA, Mayer RJ, Ota DM, Steele GD, Evans D, Roh M, Sugarbaker DJ, Dumas P, Gray C, Vena DA
J Natl Cancer Inst 1993 Nov 17;85(22):1839-44. doi: 10.1093/jnci/85.22.1839. PMID: 8230264
Combined modality of radiation and chemotherapy for the treatment of gastric carcinoma. A review.
Queisser W, Heim ME
Onkologie 1989 Aug;12(4):156-60. doi: 10.1159/000216630. PMID: 2677873
Current management of advanced and locally unresectable gastric carcinoma.
Schein PS, Smith FP, Woolley PV, Ahlgren JD
Cancer 1982 Dec 1;50(11 Suppl):2590-6. PMID: 6754066

Prognosis

Neoadjuvant chemotherapy in advanced gastric cancer--results of a pilot study.
Shukla NK, Deo SV, Asthana S, Raina V, Dronamaraju SS
Trop Gastroenterol 2002 Apr-Jun;23(2):94-6. PMID: 12632980
Stomach-partitioning gastrojejunostomy for unresectable gastric carcinoma.
Kaminishi M, Yamaguchi H, Shimizu N, Nomura S, Yoshikawa A, Hashimoto M, Sakai S, Oohara T
Arch Surg 1997 Feb;132(2):184-7. doi: 10.1001/archsurg.1997.01430260082018. PMID: 9041924
Potentially resectable gastric carcinoma: current approaches to staging and preoperative therapy.
Ajani JA, Mansfield PF, Ota DM
World J Surg 1995 Mar-Apr;19(2):216-20. doi: 10.1007/BF00308629. PMID: 7754626
Preoperative and postoperative combination chemotherapy for potentially resectable gastric carcinoma.
Ajani JA, Mayer RJ, Ota DM, Steele GD, Evans D, Roh M, Sugarbaker DJ, Dumas P, Gray C, Vena DA
J Natl Cancer Inst 1993 Nov 17;85(22):1839-44. doi: 10.1093/jnci/85.22.1839. PMID: 8230264
Current management of advanced and locally unresectable gastric carcinoma.
Schein PS, Smith FP, Woolley PV, Ahlgren JD
Cancer 1982 Dec 1;50(11 Suppl):2590-6. PMID: 6754066

Clinical prediction guides

Neoadjuvant chemotherapy in advanced gastric cancer--results of a pilot study.
Shukla NK, Deo SV, Asthana S, Raina V, Dronamaraju SS
Trop Gastroenterol 2002 Apr-Jun;23(2):94-6. PMID: 12632980
Immunohistochemical expression of vascular endothelial growth factor can predict response to 5-fluorouracil and cisplatin in patients with gastric adenocarcinoma.
Takiuchi H, Hirata I, Kawabe S, Egashira Y, Katsu K
Oncol Rep 2000 Jul-Aug;7(4):841-6. doi: 10.3892/or.7.4.841. PMID: 10854555
Combined modality of radiation and chemotherapy for the treatment of gastric carcinoma. A review.
Queisser W, Heim ME
Onkologie 1989 Aug;12(4):156-60. doi: 10.1159/000216630. PMID: 2677873

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