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Prolonged reptilase time

MedGen UID:
1687820
Concept ID:
C5209275
Finding
HPO: HP:0020193

Definition

An abnormally increased duration of the reptilase time. Reptilase time is a functional plasma clotting assay, which is based on the enzymatic activity of batroxobin. By specifically cleaving fibrinogen A from fibrinogen, batroxobin leads to the formation of a stable fibrin clot. The time, starting from the addition of batroxobin to the plasma sample, until clot formation is the reptilase time and is given in seconds. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProlonged reptilase time

Professional guidelines

PubMed

Levi M
Crit Care 2016 Aug 20;20:249. doi: 10.1186/s13054-016-1413-3. PMID: 27543264Free PMC Article
Boey JP, Gallus A
Drugs Aging 2016 Jul;33(7):475-90. doi: 10.1007/s40266-016-0378-x. PMID: 27255713
Tiede A, Scharf RE, Dobbelstein C, Werwitzke S
Hamostaseologie 2015;35(4):311-8. Epub 2015 Jan 7 doi: 10.5482/HAMO-14-11-0064. PMID: 25564260

Recent clinical studies

Etiology

Pengo V, Levi Minzi S, Dal Bo Zanon R, Cappellato G, Farinati F, Girolami A
J Med 1984;15(2):149-60. PMID: 6096471

Diagnosis

Karapetian H
Methods Mol Biol 2013;992:273-7. doi: 10.1007/978-1-62703-339-8_20. PMID: 23546720
Walter S, Stabler S, Lefkowitz JB
Haemophilia 2006 Jul;12(4):393-7. doi: 10.1111/j.1365-2516.2006.01300.x. PMID: 16834739
Tefferi A, Owen BA, Nichols WL, Witzig TE, Owen WG
Blood 1989 Jul;74(1):252-4. PMID: 2752113
Pengo V, Levi Minzi S, Dal Bo Zanon R, Cappellato G, Farinati F, Girolami A
J Med 1984;15(2):149-60. PMID: 6096471

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