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High Risk Meningioma

MedGen UID:
1686580
•Concept ID:
C5205551
•
Neoplastic Process
Synonym: High-Risk Meningioma

Definition

Meningioma that is classified as 1) a newly diagnosed or recurrent WHO grade III meningioma 2) a recurrent WHO grade II meningioma or 3) a newly diagnosed WHO grade II meningioma with subtotal resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Risk Meningioma

Professional guidelines

PubMed

The "Combo" radiotherapy treatment for high-risk grade 2 meningiomas: dose escalation and initial safety and efficacy analysis.
Pontoriero A, Critelli P, Conti A, Cardali S, Angileri FF, Germanò A, Lillo S, Carretta A, Brogna A, Santacaterina A, Parisi S, Pergolizzi S
J Neurooncol 2023 Jan;161(2):203-214. Epub 2022 Aug 4 doi: 10.1007/s11060-022-04107-3. PMID: 35927392
Treatment of high risk or recurrent meningiomas with hydroxyurea.
Rosenthal MA, Ashley DL, Cher L
J Clin Neurosci 2002 Mar;9(2):156-8. doi: 10.1054/jocn.2001.1019. PMID: 11922703

Recent clinical studies

Etiology

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC
Cell Genom 2024 Jun 12;4(6):100566. Epub 2024 May 23 doi: 10.1016/j.xgen.2024.100566. PMID: 38788713Free PMC Article
The "Combo" radiotherapy treatment for high-risk grade 2 meningiomas: dose escalation and initial safety and efficacy analysis.
Pontoriero A, Critelli P, Conti A, Cardali S, Angileri FF, Germanò A, Lillo S, Carretta A, Brogna A, Santacaterina A, Parisi S, Pergolizzi S
J Neurooncol 2023 Jan;161(2):203-214. Epub 2022 Aug 4 doi: 10.1007/s11060-022-04107-3. PMID: 35927392
Multisession radiosurgery for grade 2 (WHO), high risk meningiomas. A phase II clinical trial.
Marchetti M, Pinzi V, Iezzoni C, Morlino S, Tramacere I, De Martin E, Cane I, Fariselli L
J Neurooncol 2022 May;157(3):397-403. Epub 2022 Apr 4 doi: 10.1007/s11060-022-03978-w. PMID: 35378640Free PMC Article
High-risk Meningioma: Initial Outcomes From NRG Oncology/RTOG 0539.
Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Fogh SE, Youssef E, Deb N, Kwok Y, Robinson CG, Shu HK, Fisher BJ, Panet-Raymond V, McMillan WG, de Groot JF, Zhang P, Mehta MP
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):790-799. Epub 2019 Nov 29 doi: 10.1016/j.ijrobp.2019.11.028. PMID: 31786276Free PMC Article
Dose-painting intensity-modulated proton therapy for intermediate- and high-risk meningioma.
Madani I, Lomax AJ, Albertini F, Trnková P, Weber DC
Radiat Oncol 2015 Mar 30;10:72. doi: 10.1186/s13014-015-0384-x. PMID: 25890217Free PMC Article

Diagnosis

Dose-painting intensity-modulated proton therapy for intermediate- and high-risk meningioma.
Madani I, Lomax AJ, Albertini F, Trnková P, Weber DC
Radiat Oncol 2015 Mar 30;10:72. doi: 10.1186/s13014-015-0384-x. PMID: 25890217Free PMC Article

Therapy

The "Combo" radiotherapy treatment for high-risk grade 2 meningiomas: dose escalation and initial safety and efficacy analysis.
Pontoriero A, Critelli P, Conti A, Cardali S, Angileri FF, Germanò A, Lillo S, Carretta A, Brogna A, Santacaterina A, Parisi S, Pergolizzi S
J Neurooncol 2023 Jan;161(2):203-214. Epub 2022 Aug 4 doi: 10.1007/s11060-022-04107-3. PMID: 35927392
Multisession radiosurgery for grade 2 (WHO), high risk meningiomas. A phase II clinical trial.
Marchetti M, Pinzi V, Iezzoni C, Morlino S, Tramacere I, De Martin E, Cane I, Fariselli L
J Neurooncol 2022 May;157(3):397-403. Epub 2022 Apr 4 doi: 10.1007/s11060-022-03978-w. PMID: 35378640Free PMC Article
High-risk Meningioma: Initial Outcomes From NRG Oncology/RTOG 0539.
Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Fogh SE, Youssef E, Deb N, Kwok Y, Robinson CG, Shu HK, Fisher BJ, Panet-Raymond V, McMillan WG, de Groot JF, Zhang P, Mehta MP
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):790-799. Epub 2019 Nov 29 doi: 10.1016/j.ijrobp.2019.11.028. PMID: 31786276Free PMC Article
Carbon ion radiotherapy performed as re-irradiation using active beam delivery in patients with tumors of the brain, skull base and sacral region.
Combs SE, Kalbe A, Nikoghosyan A, Ackermann B, Jäkel O, Haberer T, Debus J
Radiother Oncol 2011 Jan;98(1):63-7. Epub 2010 Nov 25 doi: 10.1016/j.radonc.2010.10.010. PMID: 21112107
Treatment of high risk or recurrent meningiomas with hydroxyurea.
Rosenthal MA, Ashley DL, Cher L
J Clin Neurosci 2002 Mar;9(2):156-8. doi: 10.1054/jocn.2001.1019. PMID: 11922703

Prognosis

The Prognostic Role of Fibulin-2 and Ki-67 Index in Patients with Meningioma: A Study among Minangkabau Ethnicity.
Setiawati Y, Alimuddin T, Mulyani H, Kamelia M
Asian Pac J Cancer Prev 2024 Aug 1;25(8):2735-2742. doi: 10.31557/APJCP.2024.25.8.2735. PMID: 39205571Free PMC Article
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC
Cell Genom 2024 Jun 12;4(6):100566. Epub 2024 May 23 doi: 10.1016/j.xgen.2024.100566. PMID: 38788713Free PMC Article
The "Combo" radiotherapy treatment for high-risk grade 2 meningiomas: dose escalation and initial safety and efficacy analysis.
Pontoriero A, Critelli P, Conti A, Cardali S, Angileri FF, Germanò A, Lillo S, Carretta A, Brogna A, Santacaterina A, Parisi S, Pergolizzi S
J Neurooncol 2023 Jan;161(2):203-214. Epub 2022 Aug 4 doi: 10.1007/s11060-022-04107-3. PMID: 35927392
Multisession radiosurgery for grade 2 (WHO), high risk meningiomas. A phase II clinical trial.
Marchetti M, Pinzi V, Iezzoni C, Morlino S, Tramacere I, De Martin E, Cane I, Fariselli L
J Neurooncol 2022 May;157(3):397-403. Epub 2022 Apr 4 doi: 10.1007/s11060-022-03978-w. PMID: 35378640Free PMC Article
Dose-painting intensity-modulated proton therapy for intermediate- and high-risk meningioma.
Madani I, Lomax AJ, Albertini F, Trnková P, Weber DC
Radiat Oncol 2015 Mar 30;10:72. doi: 10.1186/s13014-015-0384-x. PMID: 25890217Free PMC Article

Clinical prediction guides

The Prognostic Role of Fibulin-2 and Ki-67 Index in Patients with Meningioma: A Study among Minangkabau Ethnicity.
Setiawati Y, Alimuddin T, Mulyani H, Kamelia M
Asian Pac J Cancer Prev 2024 Aug 1;25(8):2735-2742. doi: 10.31557/APJCP.2024.25.8.2735. PMID: 39205571Free PMC Article
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC
Cell Genom 2024 Jun 12;4(6):100566. Epub 2024 May 23 doi: 10.1016/j.xgen.2024.100566. PMID: 38788713Free PMC Article
The "Combo" radiotherapy treatment for high-risk grade 2 meningiomas: dose escalation and initial safety and efficacy analysis.
Pontoriero A, Critelli P, Conti A, Cardali S, Angileri FF, Germanò A, Lillo S, Carretta A, Brogna A, Santacaterina A, Parisi S, Pergolizzi S
J Neurooncol 2023 Jan;161(2):203-214. Epub 2022 Aug 4 doi: 10.1007/s11060-022-04107-3. PMID: 35927392

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