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Abnormal CSF albumin concentration

MedGen UID:
1685238
•Concept ID:
C5139623
•
Finding
Synonym: Abnormal albumin levels in cerebrospinal fluid
 
HPO: HP:0500238

Definition

Any deviation from the normal concentration of albumin in the cerebrospinal fluid. [from HPO]

Professional guidelines

PubMed

Cerebrospinal fluid beta 2-microglobulin in patients with AIDS dementia complex: an expanded series including response to zidovudine treatment.
Brew BJ, Bhalla RB, Paul M, Sidtis JJ, Keilp JJ, Sadler AE, Gallardo H, McArthur JC, Schwartz MK, Price RW
AIDS 1992 May;6(5):461-5. PMID: 1616651

Recent clinical studies

Etiology

Associations between liver function and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in non-demented adults: The CABLE study.
Gao PY, Ou YN, Huang YM, Wang ZB, Fu Y, Ma YH, Li QY, Ma LY, Cui RP, Mi YC, Tan L, Yu JT
J Neurochem 2024 Jan;168(1):39-51. Epub 2023 Dec 6 doi: 10.1111/jnc.16025. PMID: 38055867
COVID-19 Recovery: Consistent Absence of Cerebrospinal Fluid Biomarker Abnormalities in Patients With Neurocognitive Post-COVID Complications.
Kanberg N, Grahn A, Stentoft E, Bremell D, Yilmaz A, Studahl M, Nilsson S, Schöll M, Gostner JM, Blennow K, Zetterberg H, Padmanabhan N, Cohen R, Misaghian S, Romero D, Campbell C, Mathew A, Wang M, Sigal G, Stengelin M, Edén A, Gisslén M
J Infect Dis 2024 Feb 14;229(2):493-501. doi: 10.1093/infdis/jiad395. PMID: 37874918Free PMC Article
Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway.
Tigchelaar C, van Zuylen ML, Hulst AH, Preckel B, van Beek AP, Kema IP, Hermanides J, Absalom AR
Diabetologia 2022 Jul;65(7):1098-1107. Epub 2022 Apr 5 doi: 10.1007/s00125-022-05693-7. PMID: 35380232Free PMC Article
Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren's syndrome.
Tjensvoll AB, Lauvsnes MB, Zetterberg H, Kvaløy JT, Kvivik I, Maroni SS, Greve OJ, Beyer MK, Hirohata S, Putterman C, Alves G, Harboe E, Blennow K, Gøransson LG, Omdal R
J Neurol 2021 Apr;268(4):1385-1394. Epub 2020 Oct 30 doi: 10.1007/s00415-020-10290-y. PMID: 33128084Free PMC Article
Evidence of cerebrospinal fluid abnormalities in patients with depressive syndromes.
Endres D, Perlov E, Dersch R, Baumgartner A, Hottenrott T, Berger B, Stich O, Tebartz van Elst L
J Affect Disord 2016 Jul 1;198:178-84. Epub 2016 Mar 10 doi: 10.1016/j.jad.2016.03.030. PMID: 27017374

Diagnosis

Neurofilament light in plasma is a potential biomarker of central nervous system involvement in systemic lupus erythematosus.
Lauvsnes MB, Zetterberg H, Blennow K, Kvaløy JT, Tjensvoll AB, Maroni S, Beyer MK, Greve OJ, Kvivik I, Alves G, Gøransson LG, Harboe E, Hirohata S, Omdal R
J Neurol 2022 Jun;269(6):3064-3074. Epub 2021 Nov 20 doi: 10.1007/s00415-021-10893-z. PMID: 34800169
Secondary syphilis with ocular involvement in a HIV-infected patient - case report.
Olszewska AM, Reduta T, Bacharewicz-Szczerbicka J, Flisiak I
Przegl Epidemiol 2021;75(2):175-183. doi: 10.32394/pe.75.16. PMID: 34696554
Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection.
Liu LL, Zhang HL, Huang SJ, Liu L, Tong ML, Lin LR, Chen YY, Xi Y, Guo XJ, Zhang YF
Int Immunopharmacol 2013 Dec;17(4):1120-4. doi: 10.1016/j.intimp.2013.10.008. PMID: 24459685
Cerebrospinal fluid alterations in herpes simplex virus encephalitis.
Koskiniemi M, Vaheri A, Taskinen E
Rev Infect Dis 1984 Sep-Oct;6(5):608-18. doi: 10.1093/clinids/6.5.608. PMID: 6095403
Cerebrospinal fluid and blood assays of diagnostic usefulness in multiple sclerosis.
Johnson KP
Neurology 1980 Jul;30(7 Pt 2):106-9. doi: 10.1212/wnl.30.7_part_2.106. PMID: 6156430

Therapy

Impact of blood-brain barrier disruption on newly diagnosed neuromyelitis optica spectrum disorder symptoms and prognosis.
Liang S, Qin Q, Tang Y, Liao W, Yang Y, He J, Li L
Ann Palliat Med 2020 Mar;9(2):324-330. doi: 10.21037/apm.2019.12.12. PMID: 32268769
A randomized clinical trial to evaluate the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in embryo culture medium for in vitro fertilization.
Ziebe S, Loft A, Povlsen BB, Erb K, Agerholm I, Aasted M, Gabrielsen A, Hnida C, Zobel DP, Munding B, Bendz SH, Robertson SA
Fertil Steril 2013 May;99(6):1600-9. Epub 2013 Feb 4 doi: 10.1016/j.fertnstert.2012.12.043. PMID: 23380186
Cerebrospinal fluid protein concentrations related to clinical findings in patients with sciatica caused by disk herniation.
Skouen JS, Larsen JL, Vollset SE
J Spinal Disord 1994 Feb;7(1):12-8. doi: 10.1097/00002517-199407010-00002. PMID: 8186584
Dexamethasone therapy for bacterial meningitis in children. Swiss Meningitis Study Group.
Schaad UB, Lips U, Gnehm HE, Blumberg A, Heinzer I, Wedgwood J
Lancet 1993 Aug 21;342(8869):457-61. doi: 10.1016/0140-6736(93)91592-a. PMID: 8102428
Steroid hormones and steroid hormone binding globulins in cerebrospinal fluid studied in individuals with intact and with disturbed blood-cerebrospinal fluid barrier.
Schwarz S, Pohl P
Neuroendocrinology 1992 Feb;55(2):174-82. doi: 10.1159/000126112. PMID: 1620285

Prognosis

Impact of blood-brain barrier disruption on newly diagnosed neuromyelitis optica spectrum disorder symptoms and prognosis.
Liang S, Qin Q, Tang Y, Liao W, Yang Y, He J, Li L
Ann Palliat Med 2020 Mar;9(2):324-330. doi: 10.21037/apm.2019.12.12. PMID: 32268769
Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection.
Liu LL, Zhang HL, Huang SJ, Liu L, Tong ML, Lin LR, Chen YY, Xi Y, Guo XJ, Zhang YF
Int Immunopharmacol 2013 Dec;17(4):1120-4. doi: 10.1016/j.intimp.2013.10.008. PMID: 24459685
Validation of serum markers for blood-brain barrier disruption in traumatic brain injury.
Blyth BJ, Farhavar A, Gee C, Hawthorn B, He H, Nayak A, Stöcklein V, Bazarian JJ
J Neurotrauma 2009 Sep;26(9):1497-1507. doi: 10.1089/neu.2008.0738. PMID: 19257803Free PMC Article
Effect of hypoimmunoglobulinemia on laboratory evaluation of multiple sclerosis.
Nguyen N, Wong SS
J Med 1992;23(2):133-9. PMID: 1512521
Cerebrospinal fluid and blood assays of diagnostic usefulness in multiple sclerosis.
Johnson KP
Neurology 1980 Jul;30(7 Pt 2):106-9. doi: 10.1212/wnl.30.7_part_2.106. PMID: 6156430

Clinical prediction guides

Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway.
Tigchelaar C, van Zuylen ML, Hulst AH, Preckel B, van Beek AP, Kema IP, Hermanides J, Absalom AR
Diabetologia 2022 Jul;65(7):1098-1107. Epub 2022 Apr 5 doi: 10.1007/s00125-022-05693-7. PMID: 35380232Free PMC Article
Secondary syphilis with ocular involvement in a HIV-infected patient - case report.
Olszewska AM, Reduta T, Bacharewicz-Szczerbicka J, Flisiak I
Przegl Epidemiol 2021;75(2):175-183. doi: 10.32394/pe.75.16. PMID: 34696554
Effect of hypoimmunoglobulinemia on laboratory evaluation of multiple sclerosis.
Nguyen N, Wong SS
J Med 1992;23(2):133-9. PMID: 1512521
Cerebrospinal fluid alterations in herpes simplex virus encephalitis.
Koskiniemi M, Vaheri A, Taskinen E
Rev Infect Dis 1984 Sep-Oct;6(5):608-18. doi: 10.1093/clinids/6.5.608. PMID: 6095403
Cerebrospinal fluid protein findings in various lower back pain syndromes.
Ahonen A, Myllylä VV, Hokkanen E
Acta Neurol Scand 1979 Aug;60(2):93-9. doi: 10.1111/j.1600-0404.1979.tb02956.x. PMID: 158934

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