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Chronic Kidney Disease due to Diabetes Mellitus

MedGen UID:
1683411
•Concept ID:
C4763864
•
Disease or Syndrome

Definition

Longstanding kidney disease as a complication of diabetes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic Kidney Disease due to Diabetes Mellitus

Professional guidelines

PubMed

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment.
Samsu N
Biomed Res Int 2021;2021:1497449. Epub 2021 Jul 8 doi: 10.1155/2021/1497449. PMID: 34307650Free PMC Article
Chronic Kidney Disease Diagnosis and Management: A Review.
Chen TK, Knicely DH, Grams ME
JAMA 2019 Oct 1;322(13):1294-1304. doi: 10.1001/jama.2019.14745. PMID: 31573641Free PMC Article
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Recent clinical studies

Etiology

KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease.
Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
Kidney Int 2022 Nov;102(5S):S1-S127. doi: 10.1016/j.kint.2022.06.008. PMID: 36272764
Diabetes Management in Chronic Kidney Disease: A Consensus Report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO).
de Boer IH, Khunti K, Sadusky T, Tuttle KR, Neumiller JJ, Rhee CM, Rosas SE, Rossing P, Bakris G
Diabetes Care 2022 Dec 1;45(12):3075-3090. doi: 10.2337/dci22-0027. PMID: 36189689Free PMC Article
Chronic Kidney Disease: Strategies to Retard Progression.
Yan MT, Chao CT, Lin SH
Int J Mol Sci 2021 Sep 18;22(18) doi: 10.3390/ijms221810084. PMID: 34576247Free PMC Article
Effects of Dapagliflozin in Stage 4 Chronic Kidney Disease.
Chertow GM, Vart P, Jongs N, Toto RD, Gorriz JL, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Sjöström CD, Stefánsson BV, Langkilde AM, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
J Am Soc Nephrol 2021 Sep;32(9):2352-2361. Epub 2021 Jul 16 doi: 10.1681/ASN.2021020167. PMID: 34272327Free PMC Article
Glycemic Monitoring and Management in Advanced Chronic Kidney Disease.
Galindo RJ, Beck RW, Scioscia MF, Umpierrez GE, Tuttle KR
Endocr Rev 2020 Oct 1;41(5):756-74. doi: 10.1210/endrev/bnaa017. PMID: 32455432Free PMC Article

Diagnosis

The cardio-renal-metabolic connection: a review of the evidence.
Marassi M, Fadini GP
Cardiovasc Diabetol 2023 Jul 31;22(1):195. doi: 10.1186/s12933-023-01937-x. PMID: 37525273Free PMC Article
Diabetic Kidney Disease: An Update.
Gupta S, Dominguez M, Golestaneh L
Med Clin North Am 2023 Jul;107(4):689-705. Epub 2023 Apr 7 doi: 10.1016/j.mcna.2023.03.004. PMID: 37258007
KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease.
Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
Kidney Int 2022 Nov;102(5S):S1-S127. doi: 10.1016/j.kint.2022.06.008. PMID: 36272764
Diabetes Management in Chronic Kidney Disease: A Consensus Report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO).
de Boer IH, Khunti K, Sadusky T, Tuttle KR, Neumiller JJ, Rhee CM, Rosas SE, Rossing P, Bakris G
Diabetes Care 2022 Dec 1;45(12):3075-3090. doi: 10.2337/dci22-0027. PMID: 36189689Free PMC Article
Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial.
Wheeler DC, Stefánsson BV, Jongs N, Chertow GM, Greene T, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Toto RD, Sjöström CD, Langkilde AM, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
Lancet Diabetes Endocrinol 2021 Jan;9(1):22-31. doi: 10.1016/S2213-8587(20)30369-7. PMID: 33338413

Therapy

The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease.
Rossing P, Baeres FMM, Bakris G, Bosch-Traberg H, Gislum M, Gough SCL, Idorn T, Lawson J, Mahaffey KW, Mann JFE, Mersebach H, Perkovic V, Tuttle K, Pratley R
Nephrol Dial Transplant 2023 Aug 31;38(9):2041-2051. doi: 10.1093/ndt/gfad009. PMID: 36651820Free PMC Article
Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials.
Nuffield Department of Population Health Renal Studies Group; SGLT2 inhibitor Meta-Analysis Cardio-Renal Trialists' Consortium
Lancet 2022 Nov 19;400(10365):1788-1801. Epub 2022 Nov 6 doi: 10.1016/S0140-6736(22)02074-8. PMID: 36351458Free PMC Article
Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis.
Agarwal R, Filippatos G, Pitt B, Anker SD, Rossing P, Joseph A, Kolkhof P, Nowack C, Gebel M, Ruilope LM, Bakris GL; FIDELIO-DKD and FIGARO-DKD investigators
Eur Heart J 2022 Feb 10;43(6):474-484. doi: 10.1093/eurheartj/ehab777. PMID: 35023547Free PMC Article
Effects of Dapagliflozin in Stage 4 Chronic Kidney Disease.
Chertow GM, Vart P, Jongs N, Toto RD, Gorriz JL, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Sjöström CD, Stefánsson BV, Langkilde AM, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
J Am Soc Nephrol 2021 Sep;32(9):2352-2361. Epub 2021 Jul 16 doi: 10.1681/ASN.2021020167. PMID: 34272327Free PMC Article
Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial.
Wheeler DC, Stefánsson BV, Jongs N, Chertow GM, Greene T, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Toto RD, Sjöström CD, Langkilde AM, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
Lancet Diabetes Endocrinol 2021 Jan;9(1):22-31. doi: 10.1016/S2213-8587(20)30369-7. PMID: 33338413

Prognosis

The cardio-renal-metabolic connection: a review of the evidence.
Marassi M, Fadini GP
Cardiovasc Diabetol 2023 Jul 31;22(1):195. doi: 10.1186/s12933-023-01937-x. PMID: 37525273Free PMC Article
Finerenone Reduces Risk of Incident Heart Failure in Patients With Chronic Kidney Disease and Type 2 Diabetes: Analyses From the FIGARO-DKD Trial.
Filippatos G, Anker SD, Agarwal R, Ruilope LM, Rossing P, Bakris GL, Tasto C, Joseph A, Kolkhof P, Lage A, Pitt B; FIGARO-DKD Investigators
Circulation 2022 Feb 8;145(6):437-447. Epub 2021 Nov 13 doi: 10.1161/CIRCULATIONAHA.121.057983. PMID: 34775784Free PMC Article
Hyperkalemia Risk with Finerenone: Results from the FIDELIO-DKD Trial.
Agarwal R, Joseph A, Anker SD, Filippatos G, Rossing P, Ruilope LM, Pitt B, Kolkhof P, Scott C, Lawatscheck R, Wilson DJ, Bakris GL; FIDELIO-DKD Investigators
J Am Soc Nephrol 2022 Jan;33(1):225-237. Epub 2021 Nov 3 doi: 10.1681/ASN.2021070942. PMID: 34732509Free PMC Article
Diabetes, heart failure, and renal dysfunction: The vicious circles.
Braunwald E
Prog Cardiovasc Dis 2019 Jul-Aug;62(4):298-302. Epub 2019 Aug 1 doi: 10.1016/j.pcad.2019.07.003. PMID: 31377223
Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease.
Thomas MC, Cooper ME, Zimmet P
Nat Rev Nephrol 2016 Feb;12(2):73-81. Epub 2015 Nov 10 doi: 10.1038/nrneph.2015.173. PMID: 26553517

Clinical prediction guides

MAFLD and CKD: An Updated Narrative Review.
Mantovani A, Lombardi R, Cattazzo F, Zusi C, Cappelli D, Dalbeni A
Int J Mol Sci 2022 Jun 23;23(13) doi: 10.3390/ijms23137007. PMID: 35806010Free PMC Article
Kidney and heart failure outcomes associated with SGLT2 inhibitor use.
van der Aart-van der Beek AB, de Boer RA, Heerspink HJL
Nat Rev Nephrol 2022 May;18(5):294-306. Epub 2022 Feb 10 doi: 10.1038/s41581-022-00535-6. PMID: 35145275
Renal Protection with SGLT2 Inhibitors: Effects in Acute and Chronic Kidney Disease.
Bailey CJ, Day C, Bellary S
Curr Diab Rep 2022 Jan;22(1):39-52. Epub 2022 Feb 3 doi: 10.1007/s11892-021-01442-z. PMID: 35113333Free PMC Article
Effects of Dapagliflozin in Stage 4 Chronic Kidney Disease.
Chertow GM, Vart P, Jongs N, Toto RD, Gorriz JL, Hou FF, McMurray JJV, Correa-Rotter R, Rossing P, Sjöström CD, Stefánsson BV, Langkilde AM, Wheeler DC, Heerspink HJL; DAPA-CKD Trial Committees and Investigators
J Am Soc Nephrol 2021 Sep;32(9):2352-2361. Epub 2021 Jul 16 doi: 10.1681/ASN.2021020167. PMID: 34272327Free PMC Article
Glycemic Monitoring and Management in Advanced Chronic Kidney Disease.
Galindo RJ, Beck RW, Scioscia MF, Umpierrez GE, Tuttle KR
Endocr Rev 2020 Oct 1;41(5):756-74. doi: 10.1210/endrev/bnaa017. PMID: 32455432Free PMC Article

Recent systematic reviews

Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials.
Shi Q, Nong K, Vandvik PO, Guyatt GH, Schnell O, Rydén L, Marx N, Brosius FC 3rd, Mustafa RA, Agarwal A, Zou X, Mao Y, Asadollahifar A, Chowdhury SR, Zhai C, Gupta S, Gao Y, Lima JP, Numata K, Qiao Z, Fan Q, Yang Q, Jin Y, Ge L, Yang Q, Zhu H, Yang F, Chen Z, Lu X, He S, Chen X, Lyu X, An X, Chen Y, Hao Q, Standl E, Siemieniuk R, Agoritsas T, Tian H, Li S
BMJ 2023 Apr 6;381:e074068. doi: 10.1136/bmj-2022-074068. PMID: 37024129Free PMC Article
Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials.
Nuffield Department of Population Health Renal Studies Group; SGLT2 inhibitor Meta-Analysis Cardio-Renal Trialists' Consortium
Lancet 2022 Nov 19;400(10365):1788-1801. Epub 2022 Nov 6 doi: 10.1016/S0140-6736(22)02074-8. PMID: 36351458Free PMC Article
Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials.
Palmer SC, Tendal B, Mustafa RA, Vandvik PO, Li S, Hao Q, Tunnicliffe D, Ruospo M, Natale P, Saglimbene V, Nicolucci A, Johnson DW, Tonelli M, Rossi MC, Badve SV, Cho Y, Nadeau-Fredette AC, Burke M, Faruque LI, Lloyd A, Ahmad N, Liu Y, Tiv S, Millard T, Gagliardi L, Kolanu N, Barmanray RD, McMorrow R, Raygoza Cortez AK, White H, Chen X, Zhou X, Liu J, Rodríguez AF, González-Colmenero AD, Wang Y, Li L, Sutanto S, Solis RC, Díaz González-Colmenero F, Rodriguez-Gutierrez R, Walsh M, Guyatt G, Strippoli GFM
BMJ 2021 Jan 13;372:m4573. doi: 10.1136/bmj.m4573. PMID: 33441402Free PMC Article
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
Zelniker TA, Wiviott SD, Raz I, Im K, Goodrich EL, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Furtado RHM, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Sabatine MS
Lancet 2019 Jan 5;393(10166):31-39. Epub 2018 Nov 10 doi: 10.1016/S0140-6736(18)32590-X. PMID: 30424892

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