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Death by Overdose

MedGen UID:
1681219
•Concept ID:
C4763739
•
Finding

Definition

A death that is attributed to an excessive amount of a substance. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeath by Overdose

Professional guidelines

PubMed

Modeling the Dynamics of Heroin and Illicit Opioid Use Disorder, Treatment, and Recovery.
Cole S, Wirkus S
Bull Math Biol 2022 Mar 2;84(4):48. doi: 10.1007/s11538-022-01002-w. PMID: 35237877Free PMC Article
Opioid substitution treatment in pretrial prison detention: a case study from Geneva, Switzerland.
Favrod-Coune T, Baroudi M, Casillas A, Rieder JP, Gétaz L, Barro J, Gaspoz JM, Broers B, Wolff H
Swiss Med Wkly 2013;143:w13898. Epub 2013 Nov 1 doi: 10.4414/smw.2013.13898. PMID: 24186493

Recent clinical studies

Etiology

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease.
Chidiac AS, Buckley NA, Noghrehchi F, Cairns R
Expert Opin Drug Metab Toxicol 2023 Jan-Jun;19(5):297-317. doi: 10.1080/17425255.2023.2223959. PMID: 37436926
Social determinants of health, substance use, and drug overdose prevention.
Sistani F, Rodriguez de Bittner M, Shaya FT
J Am Pharm Assoc (2003) 2023 Mar-Apr;63(2):628-632. Epub 2022 Oct 28 doi: 10.1016/j.japh.2022.10.023. PMID: 36411231
Overdoses and deaths related to the use of ketamine and its analogues: a systematic review.
Chaves TV, Wilffert B, Sanchez ZM
Am J Drug Alcohol Abuse 2023 Mar 4;49(2):141-150. Epub 2022 Nov 21 doi: 10.1080/00952990.2022.2132506. PMID: 36410032
Xylazine and Overdoses: Trends, Concerns, and Recommendations.
Alexander RS, Canver BR, Sue KL, Morford KL
Am J Public Health 2022 Aug;112(8):1212-1216. doi: 10.2105/AJPH.2022.306881. PMID: 35830662Free PMC Article
Treatment of opioid overdose: current approaches and recent advances.
Britch SC, Walsh SL
Psychopharmacology (Berl) 2022 Jul;239(7):2063-2081. Epub 2022 Apr 7 doi: 10.1007/s00213-022-06125-5. PMID: 35385972Free PMC Article

Diagnosis

The anomalous pharmacology of fentanyl.
Kelly E, Sutcliffe K, Cavallo D, Ramos-Gonzalez N, Alhosan N, Henderson G
Br J Pharmacol 2023 Apr;180(7):797-812. Epub 2021 Jul 2 doi: 10.1111/bph.15573. PMID: 34030211
The Role of the Nephrologist in Management of Poisoning and Intoxication: Core Curriculum 2022.
Mullins ME, Kraut JA
Am J Kidney Dis 2022 Jun;79(6):877-889. Epub 2021 Dec 9 doi: 10.1053/j.ajkd.2021.06.030. PMID: 34895948
Medication-Induced Hyperlactatemia and Lactic Acidosis: A Systematic Review of the Literature.
Smith ZR, Horng M, Rech MA
Pharmacotherapy 2019 Sep;39(9):946-963. Epub 2019 Aug 29 doi: 10.1002/phar.2316. PMID: 31361914
The epidemiology of benzodiazepine misuse: A systematic review.
Votaw VR, Geyer R, Rieselbach MM, McHugh RK
Drug Alcohol Depend 2019 Jul 1;200:95-114. Epub 2019 May 7 doi: 10.1016/j.drugalcdep.2019.02.033. PMID: 31121495Free PMC Article
Risk Factors for Opioid-Use Disorder and Overdose.
Webster LR
Anesth Analg 2017 Nov;125(5):1741-1748. doi: 10.1213/ANE.0000000000002496. PMID: 29049118

Therapy

Opioid use disorder: current trends and potential treatments.
Lee YK, Gold MS, Blum K, Thanos PK, Hanna C, Fuehrlein BS
Front Public Health 2023;11:1274719. Epub 2024 Jan 25 doi: 10.3389/fpubh.2023.1274719. PMID: 38332941Free PMC Article
Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease.
Chidiac AS, Buckley NA, Noghrehchi F, Cairns R
Expert Opin Drug Metab Toxicol 2023 Jan-Jun;19(5):297-317. doi: 10.1080/17425255.2023.2223959. PMID: 37436926
Treatment of opioid overdose: current approaches and recent advances.
Britch SC, Walsh SL
Psychopharmacology (Berl) 2022 Jul;239(7):2063-2081. Epub 2022 Apr 7 doi: 10.1007/s00213-022-06125-5. PMID: 35385972Free PMC Article
Treatment of overdose in the synthetic opioid era.
Skolnick P
Pharmacol Ther 2022 May;233:108019. Epub 2021 Oct 9 doi: 10.1016/j.pharmthera.2021.108019. PMID: 34637841
The economic burden of opioid use disorder and fatal opioid overdose in the United States, 2017.
Florence C, Luo F, Rice K
Drug Alcohol Depend 2021 Jan 1;218:108350. Epub 2020 Oct 27 doi: 10.1016/j.drugalcdep.2020.108350. PMID: 33121867Free PMC Article

Prognosis

Methamphetamine Use, Methamphetamine Use Disorder, and Associated Overdose Deaths Among US Adults.
Han B, Compton WM, Jones CM, Einstein EB, Volkow ND
JAMA Psychiatry 2021 Dec 1;78(12):1329-1342. doi: 10.1001/jamapsychiatry.2021.2588. PMID: 34550301Free PMC Article
Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality: A Cohort Study.
Larochelle MR, Bernson D, Land T, Stopka TJ, Wang N, Xuan Z, Bagley SM, Liebschutz JM, Walley AY
Ann Intern Med 2018 Aug 7;169(3):137-145. Epub 2018 Jun 19 doi: 10.7326/M17-3107. PMID: 29913516Free PMC Article
Acute lamotrigine overdose: a systematic review of published adult and pediatric cases.
Alyahya B, Friesen M, Nauche B, Laliberté M
Clin Toxicol (Phila) 2018 Feb;56(2):81-89. Epub 2017 Sep 1 doi: 10.1080/15563650.2017.1370096. PMID: 28862044
Fentanyl novel derivative-related deaths.
Giorgetti A, Centola C, Giorgetti R
Hum Psychopharmacol 2017 May;32(3) Epub 2017 Jun 21 doi: 10.1002/hup.2605. PMID: 28635020
Was it poisoning?
Flanagan RJ
Trans Med Soc Lond 2012-2013;129:40-61. PMID: 26021007

Clinical prediction guides

Psychological distress and the risk of drug overdose death.
Aram JW, Spencer MRT, Garnett MF, Hedegaard HB
J Affect Disord 2022 Dec 1;318:16-21. Epub 2022 Aug 31 doi: 10.1016/j.jad.2022.08.115. PMID: 36057284Free PMC Article
Xylazine spreads across the US: A growing component of the increasingly synthetic and polysubstance overdose crisis.
Friedman J, Montero F, Bourgois P, Wahbi R, Dye D, Goodman-Meza D, Shover C
Drug Alcohol Depend 2022 Apr 1;233:109380. Epub 2022 Feb 26 doi: 10.1016/j.drugalcdep.2022.109380. PMID: 35247724Free PMC Article
Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality: A Cohort Study.
Larochelle MR, Bernson D, Land T, Stopka TJ, Wang N, Xuan Z, Bagley SM, Liebschutz JM, Walley AY
Ann Intern Med 2018 Aug 7;169(3):137-145. Epub 2018 Jun 19 doi: 10.7326/M17-3107. PMID: 29913516Free PMC Article
Acute lamotrigine overdose: a systematic review of published adult and pediatric cases.
Alyahya B, Friesen M, Nauche B, Laliberté M
Clin Toxicol (Phila) 2018 Feb;56(2):81-89. Epub 2017 Sep 1 doi: 10.1080/15563650.2017.1370096. PMID: 28862044
Acute heroin overdose.
Sporer KA
Ann Intern Med 1999 Apr 6;130(7):584-90. doi: 10.7326/0003-4819-130-7-199904060-00019. PMID: 10189329

Recent systematic reviews

The epidemiology of benzodiazepine misuse: A systematic review.
Votaw VR, Geyer R, Rieselbach MM, McHugh RK
Drug Alcohol Depend 2019 Jul 1;200:95-114. Epub 2019 May 7 doi: 10.1016/j.drugalcdep.2019.02.033. PMID: 31121495Free PMC Article
Interventions for paracetamol (acetaminophen) overdose.
Chiew AL, Gluud C, Brok J, Buckley NA
Cochrane Database Syst Rev 2018 Feb 23;2(2):CD003328. doi: 10.1002/14651858.CD003328.pub3. PMID: 29473717Free PMC Article
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies.
Sordo L, Barrio G, Bravo MJ, Indave BI, Degenhardt L, Wiessing L, Ferri M, Pastor-Barriuso R
BMJ 2017 Apr 26;357:j1550. doi: 10.1136/bmj.j1550. PMID: 28446428Free PMC Article
CDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016.
Dowell D, Haegerich TM, Chou R
JAMA 2016 Apr 19;315(15):1624-45. doi: 10.1001/jama.2016.1464. PMID: 26977696Free PMC Article

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