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Increased CSF urate concentration

MedGen UID:
1671101
•Concept ID:
C4732838
•
Finding
Synonyms: Elevated CSF urate concentration; Increased cerebrospinal fluid urate
 
HPO: HP:0410199

Definition

Increased concentration of urate in the cerebrospinal fluid. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased CSF urate concentration

Recent clinical studies

Etiology

Serum Uric Acid May Aggravate Alzheimer's Disease Risk by Affecting Amyloidosis in Cognitively Intact Older Adults: The CABLE Study.
Li LL, Ma YH, Bi YL, Sun FR, Hu H, Hou XH, Xu W, Shen XN, Dong Q, Tan L, Yang JL, Yu JT
J Alzheimers Dis 2021;81(1):389-401. doi: 10.3233/JAD-201192. PMID: 33814427
Changes in Purines Concentration in the Cerebrospinal Fluid of Pregnant Women Experiencing Pain During Active Labor.
Schmidt AP, Böhmer AE, Hansel G, Soares FA, Oses JP, Giordani AT, Posso IP, Auler JO Jr, Mendes FF, Félix EA, Portela LV, Souza DO
Neurochem Res 2015 Nov;40(11):2262-9. Epub 2015 Sep 25 doi: 10.1007/s11064-015-1716-9. PMID: 26408294
Neutrophil activation and C-reactive protein concentration in preeclampsia.
Belo L, Santos-Silva A, Caslake M, Cooney J, Pereira-Leite L, Quintanilha A, Rebelo I
Hypertens Pregnancy 2003;22(2):129-41. doi: 10.1081/PRG-120021059. PMID: 12908997
The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity.
Lönnrot K, Metsä-Ketelä T, Molnár G, Ahonen JP, Latvala M, Peltola J, Pietilä T, Alho H
Free Radic Biol Med 1996;21(2):211-7. doi: 10.1016/0891-5849(95)02207-4. PMID: 8818636
Ascorbate concentration in human cerebrospinal fluid (CSF) and serum. Intrathecal accumulation and CSF flow rate.
Reiber H, Ruff M, Uhr M
Clin Chim Acta 1993 Aug 31;217(2):163-73. doi: 10.1016/0009-8981(93)90162-w. PMID: 8261625

Diagnosis

Serum Uric Acid May Aggravate Alzheimer's Disease Risk by Affecting Amyloidosis in Cognitively Intact Older Adults: The CABLE Study.
Li LL, Ma YH, Bi YL, Sun FR, Hu H, Hou XH, Xu W, Shen XN, Dong Q, Tan L, Yang JL, Yu JT
J Alzheimers Dis 2021;81(1):389-401. doi: 10.3233/JAD-201192. PMID: 33814427
Neutrophil activation and C-reactive protein concentration in preeclampsia.
Belo L, Santos-Silva A, Caslake M, Cooney J, Pereira-Leite L, Quintanilha A, Rebelo I
Hypertens Pregnancy 2003;22(2):129-41. doi: 10.1081/PRG-120021059. PMID: 12908997
Reference values for nucleosides and nucleobases in cerebrospinal fluid of children.
Gerrits GP, Haagen AA, De Abreu RA, Monnens LA, Gabreëls FJ, Trijbels FJ, Theeuwes AL, van Baal JM
Clin Chem 1988 Jul;34(7):1439-42. PMID: 3390913
Increased concentration of hypoxanthine in human central cerebrospinal fluid after subarachnoid haemorrhage.
von Holst H, Sollevi A
Acta Neurochir (Wien) 1985;77(1-2):52-9. doi: 10.1007/BF01402306. PMID: 4036678
Brain energy metabolism and blood-brain barrier permeability in depressive patients: analyses of creatine, creatinine, urate, and albumin in CSF and blood.
Niklasson F, Agren H
Biol Psychiatry 1984 Aug;19(8):1183-206. PMID: 6498242

Therapy

Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations.
Kastenbauer S, Koedel U, Becker BF, Pfister HW
Eur J Pharmacol 2001 Aug 10;425(2):149-52. doi: 10.1016/s0014-2999(01)01137-2. PMID: 11502281
Lesch-Nyhan syndrome and its pathogenesis: purine concentrations in plasma and urine with metabolite profiles in CSF.
Harkness RA, McCreanor GM, Watts RW
J Inherit Metab Dis 1988;11(3):239-52. doi: 10.1007/BF01800365. PMID: 3148065

Prognosis

Neutrophil activation and C-reactive protein concentration in preeclampsia.
Belo L, Santos-Silva A, Caslake M, Cooney J, Pereira-Leite L, Quintanilha A, Rebelo I
Hypertens Pregnancy 2003;22(2):129-41. doi: 10.1081/PRG-120021059. PMID: 12908997
Increased concentration of hypoxanthine in human central cerebrospinal fluid after subarachnoid haemorrhage.
von Holst H, Sollevi A
Acta Neurochir (Wien) 1985;77(1-2):52-9. doi: 10.1007/BF01402306. PMID: 4036678
Oxypurines in cerebrospinal fluid as indices of disturbed brain metabolism. A clinical study of ischemic brain diseases.
Hällgren R, Niklasson F, Terent A, Akerblom A, Widerlöv E
Stroke 1983 May-Jun;14(3):382-8. doi: 10.1161/01.str.14.3.382. PMID: 6658906

Clinical prediction guides

Changes in Purines Concentration in the Cerebrospinal Fluid of Pregnant Women Experiencing Pain During Active Labor.
Schmidt AP, Böhmer AE, Hansel G, Soares FA, Oses JP, Giordani AT, Posso IP, Auler JO Jr, Mendes FF, Félix EA, Portela LV, Souza DO
Neurochem Res 2015 Nov;40(11):2262-9. Epub 2015 Sep 25 doi: 10.1007/s11064-015-1716-9. PMID: 26408294
Preservation of the pattern of tyrosine phosphorylation in human neutrophil lysates. II. A sequential lysis protocol for the analysis of tyrosine phosphorylation-dependent signalling.
Gilbert C, Rollet-Labelle E, Naccache PH
J Immunol Methods 2002 Mar 1;261(1-2):85-101. doi: 10.1016/s0022-1759(01)00553-1. PMID: 11861068
Oxidative stress in bacterial meningitis in humans.
Kastenbauer S, Koedel U, Becker BF, Pfister HW
Neurology 2002 Jan 22;58(2):186-91. doi: 10.1212/wnl.58.2.186. PMID: 11805243
Ascorbate concentration in human cerebrospinal fluid (CSF) and serum. Intrathecal accumulation and CSF flow rate.
Reiber H, Ruff M, Uhr M
Clin Chim Acta 1993 Aug 31;217(2):163-73. doi: 10.1016/0009-8981(93)90162-w. PMID: 8261625
Oxypurines in cerebrospinal fluid as indices of disturbed brain metabolism. A clinical study of ischemic brain diseases.
Hällgren R, Niklasson F, Terent A, Akerblom A, Widerlöv E
Stroke 1983 May-Jun;14(3):382-8. doi: 10.1161/01.str.14.3.382. PMID: 6658906

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