U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eosinophilic liver infiltration

MedGen UID:
1670981
Concept ID:
C4732806
Finding
Synonym: Eosinophilic hepatitis
 
HPO: HP:0032021

Definition

Cellular infiltration of the liver parenchyma with a preponderance of eosinophils. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEosinophilic liver infiltration

Conditions with this feature

Autoinflammation, immune dysregulation, and eosinophilia
MedGen UID:
1750270
Concept ID:
C5436572
Disease or Syndrome
Autoinflammation, immune dysregulation, and eosinophilia (AIIDE) is an autosomal dominant disorder characterized by onset of severe atopic dermatitis and chronic gastrointestinal inflammation, mainly involving the colon, in infancy or early childhood. Affected individuals tend to have asthma and food or environmental allergies, as well as poor overall growth with short stature. Severe liver involvement has also been reported (Takeichi et al., 2021). Laboratory studies show increased eosinophils with normal or increased IgE levels, as well as evidence of a hyperactive immune state, including increased erythrocyte sedimentation rate and C-reactive protein. Treatment with JAK inhibitors, such as ruxolitinib and tofacitinib, results in dramatic clinical improvement (summary by Gruber et al., 2020).

Professional guidelines

PubMed

Gowhari Shabgah A, Amir A, Gardanova ZR, Olegovna Zekiy A, Thangavelu L, Ebrahimi Nik M, Ahmadi M, Gholizadeh Navashenaq J
Cancer Med 2021 Aug;10(15):5191-5202. Epub 2021 Jun 15 doi: 10.1002/cam4.4060. PMID: 34128588Free PMC Article
Amruthesh TM, Kini D, Yachha SK, Rao P, Shetty SS, Kumar V
Indian J Gastroenterol 2021 Jun;40(3):338-343. Epub 2021 May 28 doi: 10.1007/s12664-021-01160-0. PMID: 34047958
Roman S, Savarino E, Savarino V, Mion F
Dig Liver Dis 2013 Nov;45(11):871-8. Epub 2013 Mar 30 doi: 10.1016/j.dld.2013.02.015. PMID: 23545170

Recent clinical studies

Etiology

Sim DW, Son DJ, Cho E, Choi SK, Shin SS, Jun CH
Gut Liver 2019 Mar 15;13(2):183-190. doi: 10.5009/gnl18266. PMID: 30376702Free PMC Article

Diagnosis

Lan T, Tai Y, Tang C
Am J Gastroenterol 2023 Jul 1;118(7):1119. Epub 2023 Feb 3 doi: 10.14309/ajg.0000000000002212. PMID: 36746416
Sim DW, Son DJ, Cho E, Choi SK, Shin SS, Jun CH
Gut Liver 2019 Mar 15;13(2):183-190. doi: 10.5009/gnl18266. PMID: 30376702Free PMC Article
Won JH, Kim MJ, Kim BM, Ji H, Chung JJ, Yoo HS, Lee JT, Park YN, Hong SW
Abdom Imaging 1999 Jul-Aug;24(4):369-72. doi: 10.1007/s002619900516. PMID: 10390559

Prognosis

Sim DW, Son DJ, Cho E, Choi SK, Shin SS, Jun CH
Gut Liver 2019 Mar 15;13(2):183-190. doi: 10.5009/gnl18266. PMID: 30376702Free PMC Article

Clinical prediction guides

Sim DW, Son DJ, Cho E, Choi SK, Shin SS, Jun CH
Gut Liver 2019 Mar 15;13(2):183-190. doi: 10.5009/gnl18266. PMID: 30376702Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...