U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Carcinoma, Pancreatic Ductal

MedGen UID:
165776
•Concept ID:
C0887833
•
Neoplastic Process
Synonyms: Carcinoma, Ductal, Pancreatic; Carcinoma, Pancreas Duct-Cell; Carcinomas, Pancreas Duct-Cell; Carcinomas, Pancreatic Ductal; Duct Cell Carcinoma of the Pancreas; Duct Cell Carcinoma, Pancreas; Duct-Cell Carcinoma of the Pancreas; Duct-Cell Carcinoma, Pancreas; Duct-Cell Carcinomas, Pancreas; Ductal Carcinoma of the Pancreas; Ductal Carcinoma, Pancreatic; Ductal Carcinomas, Pancreatic; Pancreas Duct-Cell Carcinoma; Pancreas Duct-Cell Carcinomas; Pancreatic Duct Cell Carcinoma; Pancreatic Ductal Carcinoma; Pancreatic Ductal Carcinomas

Definition

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma, Pancreatic Ductal

Professional guidelines

PubMed

Adjuvant treatment for pancreatic ductal carcinoma.
Macarulla T, Fernández T, Gallardo ME, Hernando O, López AM, Hidalgo M
Clin Transl Oncol 2017 Oct;19(10):1199-1204. Epub 2017 Jun 21 doi: 10.1007/s12094-017-1683-5. PMID: 28639051
Pancreatic carcinoma: Key-points from diagnosis to treatment.
Frampas E, David A, Regenet N, Touchefeu Y, Meyer J, Morla O
Diagn Interv Imaging 2016 Dec;97(12):1207-1223. Epub 2016 Aug 24 doi: 10.1016/j.diii.2016.07.008. PMID: 27567314
Ductal pancreatic adenocarcinoma.
Seufferlein T, Porzner M, Heinemann V, Tannapfel A, Stuschke M, Uhl W
Dtsch Arztebl Int 2014 May 30;111(22):396-402. doi: 10.3238/arztebl.2014.0396. PMID: 24980565Free PMC Article

Recent clinical studies

Etiology

Pancreatic cancer: An update on diagnosis and management.
Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983
Molecular subtypes of pancreatic cancer.
Collisson EA, Bailey P, Chang DK, Biankin AV
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):207-220. doi: 10.1038/s41575-019-0109-y. PMID: 30718832
International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017.
Isaji S, Mizuno S, Windsor JA, Bassi C, Fernández-Del Castillo C, Hackert T, Hayasaki A, Katz MHG, Kim SW, Kishiwada M, Kitagawa H, Michalski CW, Wolfgang CL
Pancreatology 2018 Jan;18(1):2-11. Epub 2017 Nov 22 doi: 10.1016/j.pan.2017.11.011. PMID: 29191513
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Pancreatic cancer.
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Diagnosis

Pancreatic cancer: An update on diagnosis and management.
Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983
Molecular subtypes of pancreatic cancer.
Collisson EA, Bailey P, Chang DK, Biankin AV
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):207-220. doi: 10.1038/s41575-019-0109-y. PMID: 30718832
International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017.
Isaji S, Mizuno S, Windsor JA, Bassi C, Fernández-Del Castillo C, Hackert T, Hayasaki A, Katz MHG, Kim SW, Kishiwada M, Kitagawa H, Michalski CW, Wolfgang CL
Pancreatology 2018 Jan;18(1):2-11. Epub 2017 Nov 22 doi: 10.1016/j.pan.2017.11.011. PMID: 29191513
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Pancreatic cancer.
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Therapy

Therapeutic developments in pancreatic cancer.
Hu ZI, O'Reilly EM
Nat Rev Gastroenterol Hepatol 2024 Jan;21(1):7-24. Epub 2023 Oct 5 doi: 10.1038/s41575-023-00840-w. PMID: 37798442
Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma.
Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C
J Hematol Oncol 2020 Oct 2;13(1):130. doi: 10.1186/s13045-020-00958-3. PMID: 33008426Free PMC Article
Challenges and Opportunities for Pancreatic Cancer Immunotherapy.
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Fibrosis and cancer: A strained relationship.
Piersma B, Hayward MK, Weaver VM
Biochim Biophys Acta Rev Cancer 2020 Apr;1873(2):188356. Epub 2020 Mar 5 doi: 10.1016/j.bbcan.2020.188356. PMID: 32147542Free PMC Article

Prognosis

Emerging Therapeutic Options in Pancreatic Cancer Management.
Delle Cave D
Int J Mol Sci 2024 Feb 5;25(3) doi: 10.3390/ijms25031929. PMID: 38339207Free PMC Article
Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K
Gastroenterology 2020 Jan;158(1):226-237.e5. Epub 2019 Aug 29 doi: 10.1053/j.gastro.2019.08.032. PMID: 31473224
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Pancreatic Ductal Adenocarcinoma and Its Variants.
Luchini C, Capelli P, Scarpa A
Surg Pathol Clin 2016 Dec;9(4):547-560. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.003. PMID: 27926359

Clinical prediction guides

Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for Pancreatic Ductal Adenocarcinoma.
George B, Kudryashova O, Kravets A, Thalji S, Malarkannan S, Kurzrock R, Chernyavskaya E, Gusakova M, Kravchenko D, Tychinin D, Savin E, Alekseeva L, Butusova A, Bagaev A, Shin N, Brown JH, Sethi I, Wang D, Taylor B, McFall T, Kamgar M, Hall WA, Erickson B, Christians KK, Evans DB, Tsai S
Gastroenterology 2024 May;166(5):859-871.e3. Epub 2024 Jan 25 doi: 10.1053/j.gastro.2024.01.028. PMID: 38280684
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Early Detection of Pancreatic Cancer: Opportunities and Challenges.
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Imaging diagnosis of pancreatic cancer: a state-of-the-art review.
Lee ES, Lee JM
World J Gastroenterol 2014 Jun 28;20(24):7864-77. doi: 10.3748/wjg.v20.i24.7864. PMID: 24976723Free PMC Article

Recent systematic reviews

Association of high-risk stigmata and worrisome features with advanced neoplasia in intraductal papillary mucinous neoplasms (IPMN): A systematic review.
Ohno E, Balduzzi A, Hijioka S, De Pastena M, Marchegiani G, Kato H, Takenaka M, Haba S, Salvia R
Pancreatology 2024 Feb;24(1):48-61. Epub 2023 Dec 7 doi: 10.1016/j.pan.2023.12.002. PMID: 38161091
Risk factors for early-onset pancreatic ductal adenocarcinoma: A systematic literature review.
Chandana SR, Woods LM, Maxwell F, Gandolfo R, Bekaii-Saab T
Eur J Cancer 2024 Feb;198:113471. Epub 2023 Dec 12 doi: 10.1016/j.ejca.2023.113471. PMID: 38154392
Predictive ability of pancreatic cyst fluid biomarkers: A systematic review and meta-analysis.
Pflüger MJ, Jamouss KT, Afghani E, Lim SJ, Rodriguez Franco S, Mayo H, Spann M, Wang H, Singhi A, Lennon AM, Wood LD
Pancreatology 2023 Nov;23(7):868-877. Epub 2023 May 15 doi: 10.1016/j.pan.2023.05.005. PMID: 37230894
Research advances and treatment perspectives of pancreatic adenosquamous carcinoma.
Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
A systematic review of economic evaluation in pancreatic ductal adenocarcinoma.
Gérard C, Fagnoni P, Vienot A, Borg C, Limat S, Daval F, Calais F, Vardanega J, Jary M, Nerich V
Eur J Cancer 2017 Nov;86:207-216. Epub 2017 Oct 9 doi: 10.1016/j.ejca.2017.08.035. PMID: 29024890

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...