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Advanced Pancreatic Neuroendocrine Tumor

MedGen UID:
1656916
•Concept ID:
C4744859
•
Neoplastic Process
Synonym: Advanced Pancreatic Islet Cell Tumor

Definition

A pancreatic neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Pancreatic Neuroendocrine Tumor

Professional guidelines

PubMed

Temozolomide Alone or Combined with Capecitabine for the Treatment of Advanced Pancreatic Neuroendocrine Tumor.
de Mestier L, Walter T, Evrard C, de Boissieu P, Hentic O, Cros J, Tougeron D, Lombard-Bohas C, Rebours V, Hammel P, Ruszniewski P
Neuroendocrinology 2020;110(1-2):83-91. Epub 2019 May 10 doi: 10.1159/000500862. PMID: 31071715Free PMC Article
Radiotherapy in the management of pancreatic neuroendocrine tumors (PNET): experience at three institutions.
Saif MW, Ove R, Ng J, Russo S
Anticancer Res 2013 May;33(5):2175-7. PMID: 23645772

Recent clinical studies

Etiology

Temozolomide Alone or Combined with Capecitabine for the Treatment of Advanced Pancreatic Neuroendocrine Tumor.
de Mestier L, Walter T, Evrard C, de Boissieu P, Hentic O, Cros J, Tougeron D, Lombard-Bohas C, Rebours V, Hammel P, Ruszniewski P
Neuroendocrinology 2020;110(1-2):83-91. Epub 2019 May 10 doi: 10.1159/000500862. PMID: 31071715Free PMC Article
Antiangiogenic Therapy in Pancreatic Neuroendocrine Tumors.
Capozzi M, VON Arx C, DE Divitiis C, Ottaiano A, Tatangelo F, Romano GM, Tafuto S; (On behalf of ENETS Center of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples, Italy)
Anticancer Res 2016 Oct;36(10):5025-5030. doi: 10.21873/anticanres.11071. PMID: 27798861
A prospective, phase 1/2 study of everolimus and temozolomide in patients with advanced pancreatic neuroendocrine tumor.
Chan JA, Blaszkowsky L, Stuart K, Zhu AX, Allen J, Wadlow R, Ryan DP, Meyerhardt J, Gonzalez M, Regan E, Zheng H, Kulke MH
Cancer 2013 Sep 1;119(17):3212-8. Epub 2013 Jun 3 doi: 10.1002/cncr.28142. PMID: 23733618Free PMC Article
Radiotherapy in the management of pancreatic neuroendocrine tumors (PNET): experience at three institutions.
Saif MW, Ove R, Ng J, Russo S
Anticancer Res 2013 May;33(5):2175-7. PMID: 23645772
Is surgery indicated for patients with symptomatic nonfunctioning pancreatic neuroendocrine tumor and unresectable hepatic metastases?
Hung JS, Chang MC, Lee PH, Tien YW
World J Surg 2007 Dec;31(12):2392-7. doi: 10.1007/s00268-007-9264-3. PMID: 17960455

Diagnosis

Cholangitis with bacteremia due to Pseudomonas nitroreducens in a patient with pancreatic neuroendocrine tumors: a case report.
Itoh N, Akazawa N, Yamaguchi M, Murakami H, Ohkusu K
BMC Infect Dis 2024 Feb 9;24(1):180. doi: 10.1186/s12879-024-09092-8. PMID: 38336644Free PMC Article
Temozolomide Alone or Combined with Capecitabine for the Treatment of Advanced Pancreatic Neuroendocrine Tumor.
de Mestier L, Walter T, Evrard C, de Boissieu P, Hentic O, Cros J, Tougeron D, Lombard-Bohas C, Rebours V, Hammel P, Ruszniewski P
Neuroendocrinology 2020;110(1-2):83-91. Epub 2019 May 10 doi: 10.1159/000500862. PMID: 31071715Free PMC Article
Sunitinib-induced reversible purpuric rash in a patient with gastrointestinal stromal tumor.
Mutlu H, Büyükçelik A, Akça Z, Kaya N
J Oncol Pharm Pract 2014 Aug;20(4):298-301. Epub 2013 Aug 8 doi: 10.1177/1078155213495286. PMID: 23929730
Is surgery indicated for patients with symptomatic nonfunctioning pancreatic neuroendocrine tumor and unresectable hepatic metastases?
Hung JS, Chang MC, Lee PH, Tien YW
World J Surg 2007 Dec;31(12):2392-7. doi: 10.1007/s00268-007-9264-3. PMID: 17960455

Therapy

Sunitinib in Tandem With 177 Lu-DOTATATE Therapy in Advanced Pancreatic Neuroendocrine Tumor : A New Treatment Approach.
Aggarwal P, Gunasekaran V, Sood A, Gupta K, Das CK, Mittal BR
Clin Nucl Med 2024 Feb 1;49(2):e85-e86. Epub 2023 Dec 16 doi: 10.1097/RLU.0000000000005018. PMID: 38109041
Temozolomide Alone or Combined with Capecitabine for the Treatment of Advanced Pancreatic Neuroendocrine Tumor.
de Mestier L, Walter T, Evrard C, de Boissieu P, Hentic O, Cros J, Tougeron D, Lombard-Bohas C, Rebours V, Hammel P, Ruszniewski P
Neuroendocrinology 2020;110(1-2):83-91. Epub 2019 May 10 doi: 10.1159/000500862. PMID: 31071715Free PMC Article
Antiangiogenic Therapy in Pancreatic Neuroendocrine Tumors.
Capozzi M, VON Arx C, DE Divitiis C, Ottaiano A, Tatangelo F, Romano GM, Tafuto S; (On behalf of ENETS Center of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples, Italy)
Anticancer Res 2016 Oct;36(10):5025-5030. doi: 10.21873/anticanres.11071. PMID: 27798861
A prospective, phase 1/2 study of everolimus and temozolomide in patients with advanced pancreatic neuroendocrine tumor.
Chan JA, Blaszkowsky L, Stuart K, Zhu AX, Allen J, Wadlow R, Ryan DP, Meyerhardt J, Gonzalez M, Regan E, Zheng H, Kulke MH
Cancer 2013 Sep 1;119(17):3212-8. Epub 2013 Jun 3 doi: 10.1002/cncr.28142. PMID: 23733618Free PMC Article
Is surgery indicated for patients with symptomatic nonfunctioning pancreatic neuroendocrine tumor and unresectable hepatic metastases?
Hung JS, Chang MC, Lee PH, Tien YW
World J Surg 2007 Dec;31(12):2392-7. doi: 10.1007/s00268-007-9264-3. PMID: 17960455

Prognosis

Radiotherapy in the management of pancreatic neuroendocrine tumors (PNET): experience at three institutions.
Saif MW, Ove R, Ng J, Russo S
Anticancer Res 2013 May;33(5):2175-7. PMID: 23645772
Sunitinib-induced hyperammonaemia in a patient with pancreatic neuroendocrine tumour.
Shea YF, Chiu WY, Mok MY, Hung IF, Yau CC
J Clin Pharm Ther 2013 Aug;38(4):327-9. Epub 2013 Apr 16 doi: 10.1111/jcpt.12054. PMID: 23586819

Clinical prediction guides

Temozolomide Alone or Combined with Capecitabine for the Treatment of Advanced Pancreatic Neuroendocrine Tumor.
de Mestier L, Walter T, Evrard C, de Boissieu P, Hentic O, Cros J, Tougeron D, Lombard-Bohas C, Rebours V, Hammel P, Ruszniewski P
Neuroendocrinology 2020;110(1-2):83-91. Epub 2019 May 10 doi: 10.1159/000500862. PMID: 31071715Free PMC Article
A prospective, phase 1/2 study of everolimus and temozolomide in patients with advanced pancreatic neuroendocrine tumor.
Chan JA, Blaszkowsky L, Stuart K, Zhu AX, Allen J, Wadlow R, Ryan DP, Meyerhardt J, Gonzalez M, Regan E, Zheng H, Kulke MH
Cancer 2013 Sep 1;119(17):3212-8. Epub 2013 Jun 3 doi: 10.1002/cncr.28142. PMID: 23733618Free PMC Article
Radiotherapy in the management of pancreatic neuroendocrine tumors (PNET): experience at three institutions.
Saif MW, Ove R, Ng J, Russo S
Anticancer Res 2013 May;33(5):2175-7. PMID: 23645772

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