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Malignant Pancreatic Insulinoma

MedGen UID:
1655258
Concept ID:
C4721412
Neoplastic Process
Synonyms: Beta cell tumor, malignant; Insulinoma, malignant; Malignant beta cell tumor; Malignant Insulinoma; Malignant insulinoma; Pancreatic Beta Islet Cell Carcinoma; Pancreatic Insulin Producing Carcinoma
SNOMED CT: Malignant beta cell tumor (20955008); Malignant insulinoma (20955008); Malignant insulinoma (713189001); Insulinoma, malignant (20955008); Beta cell tumor, malignant (20955008)

Definition

An insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin. It displays vascular invasion and metastasizes to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Pancreatic Insulinoma

Professional guidelines

PubMed

Giannis D, Moris D, Karachaliou GS, Tsilimigras DI, Karaolanis G, Papalampros A, Felekouras E
J BUON 2020 May-Jun;25(3):1302-1314. PMID: 32862570
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Recent clinical studies

Etiology

Damaskos C, Dimitroulis D, Garmpi A, Antoniou EA, Kouraklis G, Psilopatis I, Mavri M, Diamantis E, Marinos G, Kyriakos G, Farmaki P, Patsouras A, Kontzoglou K, Garmpis N
In Vivo 2023 Nov-Dec;37(6):2402-2408. doi: 10.21873/invivo.13345. PMID: 37905620Free PMC Article
Christ E, Iacovazzo D, Korbonits M, Perren A
Endocr Relat Cancer 2023 Jun 1;30(6) Epub 2023 May 16 doi: 10.1530/ERC-22-0327. PMID: 36952647
Crinò SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, Do-Cong Pham K, Rizzatti G, Forti E, Palazzo L, Belle A, Vilmann P, van Laethem JL, Mohamadnejad M, Godat S, Hindryckx P, Benson A, Tacelli M, De Nucci G, Binda C, Kovacevic B, Jacob H, Partelli S, Falconi M, Salvia R, Landoni L; ERASING study collaborators, Larghi A
Clin Gastroenterol Hepatol 2023 Oct;21(11):2834-2843.e2. Epub 2023 Mar 4 doi: 10.1016/j.cgh.2023.02.022. PMID: 36871765
Douillard C, Jannin A, Vantyghem MC
Ann Endocrinol (Paris) 2020 Jun;81(2-3):110-117. Epub 2020 Apr 10 doi: 10.1016/j.ando.2020.04.003. PMID: 32409005
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Diagnosis

Hofland J, Refardt JC, Feelders RA, Christ E, de Herder WW
J Clin Endocrinol Metab 2024 Mar 15;109(4):1109-1118. doi: 10.1210/clinem/dgad641. PMID: 37925662Free PMC Article
Palani G, Stortz E, Moheet A
Endocr Pract 2023 Apr;29(4):286-294. Epub 2022 Dec 2 doi: 10.1016/j.eprac.2022.11.010. PMID: 36464132
Giannis D, Moris D, Karachaliou GS, Tsilimigras DI, Karaolanis G, Papalampros A, Felekouras E
J BUON 2020 May-Jun;25(3):1302-1314. PMID: 32862570
Jansen TJP, van Lith SAM, Boss M, Brom M, Joosten L, Béhé M, Buitinga M, Gotthardt M
J Labelled Comp Radiopharm 2019 Aug;62(10):656-672. doi: 10.1002/jlcr.3750. PMID: 31070270Free PMC Article
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article

Therapy

Hofland J, Refardt JC, Feelders RA, Christ E, de Herder WW
J Clin Endocrinol Metab 2024 Mar 15;109(4):1109-1118. doi: 10.1210/clinem/dgad641. PMID: 37925662Free PMC Article
Magi L, Marasco M, Rinzivillo M, Faggiano A, Panzuto F
Curr Treat Options Oncol 2023 Jul;24(7):725-741. Epub 2023 Apr 27 doi: 10.1007/s11864-023-01085-0. PMID: 37103745Free PMC Article
Crinò SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, Do-Cong Pham K, Rizzatti G, Forti E, Palazzo L, Belle A, Vilmann P, van Laethem JL, Mohamadnejad M, Godat S, Hindryckx P, Benson A, Tacelli M, De Nucci G, Binda C, Kovacevic B, Jacob H, Partelli S, Falconi M, Salvia R, Landoni L; ERASING study collaborators, Larghi A
Clin Gastroenterol Hepatol 2023 Oct;21(11):2834-2843.e2. Epub 2023 Mar 4 doi: 10.1016/j.cgh.2023.02.022. PMID: 36871765
Jansen TJP, van Lith SAM, Boss M, Brom M, Joosten L, Béhé M, Buitinga M, Gotthardt M
J Labelled Comp Radiopharm 2019 Aug;62(10):656-672. doi: 10.1002/jlcr.3750. PMID: 31070270Free PMC Article
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Prognosis

Damaskos C, Dimitroulis D, Garmpi A, Antoniou EA, Kouraklis G, Psilopatis I, Mavri M, Diamantis E, Marinos G, Kyriakos G, Farmaki P, Patsouras A, Kontzoglou K, Garmpis N
In Vivo 2023 Nov-Dec;37(6):2402-2408. doi: 10.21873/invivo.13345. PMID: 37905620Free PMC Article
Lee L, Ito T, Jensen RT
Expert Rev Anticancer Ther 2018 Sep;18(9):837-860. Epub 2018 Jul 17 doi: 10.1080/14737140.2018.1496822. PMID: 29973077Free PMC Article
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article
Oberg K
Semin Oncol 2010 Dec;37(6):594-618. doi: 10.1053/j.seminoncol.2010.10.014. PMID: 21167379
Grant CS
Surg Oncol Clin N Am 1998 Oct;7(4):819-44. PMID: 9735136

Clinical prediction guides

Crinò SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, Do-Cong Pham K, Rizzatti G, Forti E, Palazzo L, Belle A, Vilmann P, van Laethem JL, Mohamadnejad M, Godat S, Hindryckx P, Benson A, Tacelli M, De Nucci G, Binda C, Kovacevic B, Jacob H, Partelli S, Falconi M, Salvia R, Landoni L; ERASING study collaborators, Larghi A
Clin Gastroenterol Hepatol 2023 Oct;21(11):2834-2843.e2. Epub 2023 Mar 4 doi: 10.1016/j.cgh.2023.02.022. PMID: 36871765
Hackeng WM, Brosens LAA, Dreijerink KMA
Endocr Relat Cancer 2023 May 1;30(5) Epub 2023 Mar 27 doi: 10.1530/ERC-22-0321. PMID: 36779771
Balachandran A, Bhosale PR, Charnsangavej C, Tamm EP
Surg Oncol Clin N Am 2014 Oct;23(4):751-88. doi: 10.1016/j.soc.2014.07.002. PMID: 25246049
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article
Virally ML, Guillausseau PJ
Diabetes Metab 1999 Dec;25(6):477-90. PMID: 10633872

Recent systematic reviews

Guerrero-Pérez F, Vilarrasa N, Huánuco LV, Busquets J, Secanella L, Vercher-Conejero JL, Vidal N, Näf Cortés S, Villabona C
Rev Endocr Metab Disord 2023 Dec;24(6):1135-1146. Epub 2023 Jul 12 doi: 10.1007/s11154-023-09824-2. PMID: 37434098
Shah R, Garg R, Majmundar M, Purandare N, Malhotra G, Patil V, Ramteke-Jadhav S, Lila A, Shah N, Bandgar T
Clin Endocrinol (Oxf) 2021 Aug;95(2):354-364. Epub 2021 Jan 21 doi: 10.1111/cen.14406. PMID: 33386617
Hurtado-Pardo L, Cienfuegos JA, Ruiz-Canela M, Panadero P, Benito A, Hernández Lizoain JL
Rev Esp Enferm Dig 2017 Nov;109(11):778-787. doi: 10.17235/reed.2017.5044/2017. PMID: 29072081
Mehrabi A, Fischer L, Hafezi M, Dirlewanger A, Grenacher L, Diener MK, Fonouni H, Golriz M, Garoussi C, Fard N, Rahbari NN, Werner J, Büchler MW
Pancreas 2014 Jul;43(5):675-86. doi: 10.1097/MPA.0000000000000110. PMID: 24921202
Su AP, Ke NW, Zhang Y, Liu XB, Hu WM, Tian BL, Zhang ZD
J Surg Res 2014 Jan;186(1):126-34. Epub 2013 Aug 19 doi: 10.1016/j.jss.2013.07.051. PMID: 23992857

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