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Metastatic Nasopharyngeal Squamous Cell Carcinoma

MedGen UID:
1653175
•Concept ID:
C4724395
•
Neoplastic Process
Synonym: Metastatic Squamous Cell Carcinoma of the Nasopharynx

Definition

A squamous cell carcinoma of the nasopharynx which has spread from the original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Juarez-Vignon Whaley JJ, Afkhami M, Onyshchenko M, Massarelli E, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Sep;24(9):1138-1166. Epub 2023 Jun 15 doi: 10.1007/s11864-023-01101-3. PMID: 37318724Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Treatment for metastatic nasopharyngeal carcinoma.
Bensouda Y, Kaikani W, Ahbeddou N, Rahhali R, Jabri M, Mrabti H, Boussen H, Errihani H
Eur Ann Otorhinolaryngol Head Neck Dis 2011 Apr;128(2):79-85. Epub 2010 Dec 21 doi: 10.1016/j.anorl.2010.10.003. PMID: 21177151

Recent clinical studies

Etiology

Clinical significance of baseline Epstein-Barr virus DNA for recurrent or metastatic primary pulmonary lymphoepithelioma-like carcinoma.
Zou Q, Luo K, Kang L, Huang C, Mai J, Lin Y, Liang Y
Future Oncol 2023 Dec;19(37):2481-2492. Epub 2023 Dec 6 doi: 10.2217/fon-2023-0722. PMID: 38054449
Immunotherapy and Biomarker Testing in Recurrent and Metastatic Head and Neck Cancers: ASCO Guideline.
Yilmaz E, Ismaila N, Bauman JE, Dabney R, Gan G, Jordan R, Kaufman M, Kirtane K, McBride SM, Old MO, Rooper L, Saba NF, Sheth S, Subramaniam RM, Wise-Draper TM, Wong D, Mell LK
J Clin Oncol 2023 Feb 10;41(5):1132-1146. Epub 2022 Dec 15 doi: 10.1200/JCO.22.02328. PMID: 36521102
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Retreatment of recurrent nasopharyngeal carcinoma.
McNeese MD, Fletcher GH
Radiology 1981 Jan;138(1):191-3. doi: 10.1148/radiology.138.1.6779344. PMID: 6779344

Diagnosis

Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Juarez-Vignon Whaley JJ, Afkhami M, Onyshchenko M, Massarelli E, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Sep;24(9):1138-1166. Epub 2023 Jun 15 doi: 10.1007/s11864-023-01101-3. PMID: 37318724Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Nasopharyngeal carcinoma.
Wei WI, Sham JS
Lancet 2005 Jun 11-17;365(9476):2041-54. doi: 10.1016/S0140-6736(05)66698-6. PMID: 15950718
Lymphoepithelioma-like carcinoma of the skin.
Shek TW, Leung EY, Luk IS, Loong F, Chan AC, Yik YH, Lam LK
Am J Dermatopathol 1996 Dec;18(6):637-44. doi: 10.1097/00000372-199612000-00017. PMID: 8989941
Nasopharyngeal carcinoma: modes of presentation.
Skinner DW, Van Hasselt CA, Tsao SY
Ann Otol Rhinol Laryngol 1991 Jul;100(7):544-51. doi: 10.1177/000348949110000705. PMID: 2064265

Therapy

Immunotherapy and Biomarker Testing in Recurrent and Metastatic Head and Neck Cancers: ASCO Guideline.
Yilmaz E, Ismaila N, Bauman JE, Dabney R, Gan G, Jordan R, Kaufman M, Kirtane K, McBride SM, Old MO, Rooper L, Saba NF, Sheth S, Subramaniam RM, Wise-Draper TM, Wong D, Mell LK
J Clin Oncol 2023 Feb 10;41(5):1132-1146. Epub 2022 Dec 15 doi: 10.1200/JCO.22.02328. PMID: 36521102
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Adjuvant chemotherapy in head and neck cancer.
Agarwala SS
Hematol Oncol Clin North Am 1999 Aug;13(4):743-52, vii. doi: 10.1016/s0889-8588(05)70089-7. PMID: 10494510
Retreatment of recurrent nasopharyngeal carcinoma.
McNeese MD, Fletcher GH
Radiology 1981 Jan;138(1):191-3. doi: 10.1148/radiology.138.1.6779344. PMID: 6779344

Prognosis

Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer.
Wang M, Chen X, Tan P, Wang Y, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q, Wei Y, Liu Y, Chen C
Cancer Cell 2022 Sep 12;40(9):1044-1059.e8. doi: 10.1016/j.ccell.2022.08.010. PMID: 36099882
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Nasopharyngeal carcinoma.
Wei WI, Sham JS
Lancet 2005 Jun 11-17;365(9476):2041-54. doi: 10.1016/S0140-6736(05)66698-6. PMID: 15950718
Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099.
Al-Sarraf M, LeBlanc M, Giri PG, Fu KK, Cooper J, Vuong T, Forastiere AA, Adams G, Sakr WA, Schuller DE, Ensley JF
J Clin Oncol 1998 Apr;16(4):1310-7. doi: 10.1200/JCO.1998.16.4.1310. PMID: 9552031
Retreatment of recurrent nasopharyngeal carcinoma.
McNeese MD, Fletcher GH
Radiology 1981 Jan;138(1):191-3. doi: 10.1148/radiology.138.1.6779344. PMID: 6779344

Clinical prediction guides

BL-B01D1, a first-in-class EGFR-HER3 bispecific antibody-drug conjugate, in patients with locally advanced or metastatic solid tumours: a first-in-human, open-label, multicentre, phase 1 study.
Ma Y, Huang Y, Zhao Y, Zhao S, Xue J, Yang Y, Fang W, Guo Y, Han Y, Yang K, Li Y, Yang J, Fu Z, Chen G, Chen L, Zhou N, Zhou T, Zhang Y, Zhou H, Liu Q, Zhu Y, Zhu H, Xiao S, Zhang L, Zhao H
Lancet Oncol 2024 Jul;25(7):901-911. Epub 2024 May 29 doi: 10.1016/S1470-2045(24)00159-1. PMID: 38823410
Immunotherapy and Biomarker Testing in Recurrent and Metastatic Head and Neck Cancers: ASCO Guideline.
Yilmaz E, Ismaila N, Bauman JE, Dabney R, Gan G, Jordan R, Kaufman M, Kirtane K, McBride SM, Old MO, Rooper L, Saba NF, Sheth S, Subramaniam RM, Wise-Draper TM, Wong D, Mell LK
J Clin Oncol 2023 Feb 10;41(5):1132-1146. Epub 2022 Dec 15 doi: 10.1200/JCO.22.02328. PMID: 36521102
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Risk factors for severe Dysphagia after concurrent chemoradiotherapy for head and neck cancers.
Koiwai K, Shikama N, Sasaki S, Shinoda A, Kadoya M
Jpn J Clin Oncol 2009 Jul;39(7):413-7. Epub 2009 Apr 20 doi: 10.1093/jjco/hyp033. PMID: 19383615
Lymphoepithelioma-like carcinoma of the skin.
Shek TW, Leung EY, Luk IS, Loong F, Chan AC, Yik YH, Lam LK
Am J Dermatopathol 1996 Dec;18(6):637-44. doi: 10.1097/00000372-199612000-00017. PMID: 8989941

Recent systematic reviews

A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ
Cancer Treat Rev 2024 Jul;128:102772. Epub 2024 May 26 doi: 10.1016/j.ctrv.2024.102772. PMID: 38820656
The role of non-oropharyngeal biopsies in head and neck squamous cell carcinoma of unknown primary: A systematic review.
Bowe CM, Garg M
Clin Otolaryngol 2024 Sep;49(5):531-537. Epub 2024 Apr 25 doi: 10.1111/coa.14157. PMID: 38664927
Survival Outcomes in Human Papillomavirus-Associated Nonoropharyngeal Squamous Cell Carcinomas: A Systematic Review and Meta-analysis.
Sahovaler A, Kim MH, Mendez A, Palma D, Fung K, Yoo J, Nichols AC, MacNeil SD
JAMA Otolaryngol Head Neck Surg 2020 Dec 1;146(12):1158-1166. doi: 10.1001/jamaoto.2020.3382. PMID: 33057610Free PMC Article
Systematic review and meta-analyses of intensity-modulated radiation therapy versus conventional two-dimensional and/or or three-dimensional radiotherapy in curative-intent management of head and neck squamous cell carcinoma.
Gupta T, Kannan S, Ghosh-Laskar S, Agarwal JP
PLoS One 2018;13(7):e0200137. Epub 2018 Jul 6 doi: 10.1371/journal.pone.0200137. PMID: 29979726Free PMC Article
Weekly Low-Dose Versus Three-Weekly High-Dose Cisplatin for Concurrent Chemoradiation in Locoregionally Advanced Non-Nasopharyngeal Head and Neck Cancer: A Systematic Review and Meta-Analysis of Aggregate Data.
Szturz P, Wouters K, Kiyota N, Tahara M, Prabhash K, Noronha V, Castro A, Licitra L, Adelstein D, Vermorken JB
Oncologist 2017 Sep;22(9):1056-1066. Epub 2017 May 22 doi: 10.1634/theoncologist.2017-0015. PMID: 28533474Free PMC Article

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