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Metastatic Fibrolamellar Carcinoma

MedGen UID:
1652119
Concept ID:
C4727458
Neoplastic Process
Synonyms: Metastatic Fibrolamellar Hepatocellular Carcinoma; Metastatic FLC

Definition

A fibrolamellar carcinoma that has spread from the liver to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Fibrolamellar Carcinoma

Professional guidelines

PubMed

Aziz H, Brown ZJ, Panid Madani S, Kamel IR, Pawlik TM
J Am Coll Surg 2023 Feb 1;236(2):399-410. Epub 2022 Nov 4 doi: 10.1097/XCS.0000000000000476. PMID: 36648268
Hackl C, Schlitt HJ, Kirchner GI, Knoppke B, Loss M
World J Gastroenterol 2014 May 14;20(18):5331-44. doi: 10.3748/wjg.v20.i18.5331. PMID: 24833863Free PMC Article
Lee WJ, Lim HK, Jang KM, Kim SH, Lee SJ, Lim JH, Choo IW
Radiographics 2001 Oct;21 Spec No:S97-S116. doi: 10.1148/radiographics.21.suppl_1.g01oc12s97. PMID: 11598251

Recent clinical studies

Etiology

Yau T, Kaseb A, Cheng AL, Qin S, Zhu AX, Chan SL, Melkadze T, Sukeepaisarnjaroen W, Breder V, Verset G, Gane E, Borbath I, Rangel JDG, Ryoo BY, Makharadze T, Merle P, Benzaghou F, Milwee S, Wang Z, Curran D, Kelley RK, Rimassa L
Lancet Gastroenterol Hepatol 2024 Apr;9(4):310-322. Epub 2024 Feb 13 doi: 10.1016/S2468-1253(23)00454-5. PMID: 38364832
Hackl C, Schlitt HJ, Kirchner GI, Knoppke B, Loss M
World J Gastroenterol 2014 May 14;20(18):5331-44. doi: 10.3748/wjg.v20.i18.5331. PMID: 24833863Free PMC Article
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Dominguez-Malagón H, Gaytan-Graham S
Ultrastruct Pathol 2001 Nov-Dec;25(6):497-516. doi: 10.1080/019131201753343539. PMID: 11783914
Guest J, Blumgart LH
Baillieres Clin Gastroenterol 1987 Jan;1(1):131-50. doi: 10.1016/0950-3528(87)90037-6. PMID: 3034356

Diagnosis

Aziz H, Brown ZJ, Panid Madani S, Kamel IR, Pawlik TM
J Am Coll Surg 2023 Feb 1;236(2):399-410. Epub 2022 Nov 4 doi: 10.1097/XCS.0000000000000476. PMID: 36648268
O'Neill AF, Church AJ, Perez-Atayde AR, Shaikh R, Marcus KJ, Vakili K
Curr Probl Cancer 2021 Aug;45(4):100770. Epub 2021 Jul 1 doi: 10.1016/j.currproblcancer.2021.100770. PMID: 34272087
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Kamaya A, Maturen KE, Tye GA, Liu YI, Parti NN, Desser TS
Semin Ultrasound CT MR 2009 Oct;30(5):387-407. doi: 10.1053/j.sult.2009.06.001. PMID: 19842564
Guest J, Blumgart LH
Baillieres Clin Gastroenterol 1987 Jan;1(1):131-50. doi: 10.1016/0950-3528(87)90037-6. PMID: 3034356

Therapy

Yau T, Kaseb A, Cheng AL, Qin S, Zhu AX, Chan SL, Melkadze T, Sukeepaisarnjaroen W, Breder V, Verset G, Gane E, Borbath I, Rangel JDG, Ryoo BY, Makharadze T, Merle P, Benzaghou F, Milwee S, Wang Z, Curran D, Kelley RK, Rimassa L
Lancet Gastroenterol Hepatol 2024 Apr;9(4):310-322. Epub 2024 Feb 13 doi: 10.1016/S2468-1253(23)00454-5. PMID: 38364832
Leiting JL, Hernandez MC, Bergquist JR, Yonkus JA, Abdelrahman AM, Torbenson MS, Tran NH, Halfdanarson TR, Graham RP, Smoot RL, Truty MJ
In Vivo 2023 Sep-Oct;37(5):1940-1950. doi: 10.21873/invivo.13290. PMID: 37652480Free PMC Article
Lalazar G, Requena D, Ramos-Espiritu L, Ng D, Bhola PD, de Jong YP, Wang R, Narayan NJC, Shebl B, Levin S, Michailidis E, Kabbani M, Vercauteren KOA, Hurley AM, Farber BA, Hammond WJ, Saltsman JA 3rd, Weinberg EM, Glickman JF, Lyons BA, Ellison J, Schadde E, Hertl M, Leiting JL, Truty MJ, Smoot RL, Tierney F, Kato T, Wendel HG, LaQuaglia MP, Rice CM, Letai A, Coffino P, Torbenson MS, Ortiz MV, Simon SM
Cancer Discov 2021 Oct;11(10):2544-2563. Epub 2021 Jun 14 doi: 10.1158/2159-8290.CD-20-0872. PMID: 34127480Free PMC Article
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Dominguez-Malagón H, Gaytan-Graham S
Ultrastruct Pathol 2001 Nov-Dec;25(6):497-516. doi: 10.1080/019131201753343539. PMID: 11783914

Prognosis

Melehy A, Agopian V
Curr Opin Organ Transplant 2024 Feb 1;29(1):30-36. Epub 2023 Oct 18 doi: 10.1097/MOT.0000000000001118. PMID: 37851086
Aziz H, Brown ZJ, Panid Madani S, Kamel IR, Pawlik TM
J Am Coll Surg 2023 Feb 1;236(2):399-410. Epub 2022 Nov 4 doi: 10.1097/XCS.0000000000000476. PMID: 36648268
Okuda K
J Gastroenterol Hepatol 2002 Apr;17(4):401-5. doi: 10.1046/j.1440-1746.2002.02734.x. PMID: 11982719
Dominguez-Malagón H, Gaytan-Graham S
Ultrastruct Pathol 2001 Nov-Dec;25(6):497-516. doi: 10.1080/019131201753343539. PMID: 11783914
Guest J, Blumgart LH
Baillieres Clin Gastroenterol 1987 Jan;1(1):131-50. doi: 10.1016/0950-3528(87)90037-6. PMID: 3034356

Clinical prediction guides

Melehy A, Agopian V
Curr Opin Organ Transplant 2024 Feb 1;29(1):30-36. Epub 2023 Oct 18 doi: 10.1097/MOT.0000000000001118. PMID: 37851086
Hammond WJ, Lalazar G, Saltsman JA, Farber BA, Danzer E, Sherpa TC, Banda CD, Andolina JR, Karimi S, Brennan CW, Torbenson MS, La Quaglia MP, Simon SM
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26919. PMID: 29286561Free PMC Article
Grossman EJ, Millis JM
Liver Transpl 2010 Aug;16(8):930-42. doi: 10.1002/lt.22106. PMID: 20677284
Heneghan MA, O'Grady JG
Baillieres Best Pract Res Clin Gastroenterol 1999 Dec;13(4):575-91. doi: 10.1053/bega.1999.0049. PMID: 10654921
Schlitt HJ, Neipp M, Weimann A, Oldhafer KJ, Schmoll E, Boeker K, Nashan B, Kubicka S, Maschek H, Tusch G, Raab R, Ringe B, Manns MP, Pichlmayr R
J Clin Oncol 1999 Jan;17(1):324-31. doi: 10.1200/JCO.1999.17.1.324. PMID: 10458250

Recent systematic reviews

Aziz H, Brown ZJ, Panid Madani S, Kamel IR, Pawlik TM
J Am Coll Surg 2023 Feb 1;236(2):399-410. Epub 2022 Nov 4 doi: 10.1097/XCS.0000000000000476. PMID: 36648268

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