Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Type VI atherosclerotic lesion

MedGen UID:: 1645949
•Concept ID:: C4703478
•: Disease or Syndrome

HPO:	HP:0031683

Definition

Type VI atherosclerotic lesions generally have the underlying morphology of type IV or V lesions, surface disruptions, hematoma, and thrombosis may be (although less often) superimposed on any other type of lesion and even on intima without an apparent lesion. Complicating features may arise because of individual differences in risk factors and tissue reactions. These may include differences in composition of the blood, the relative quantities and distributions in the components of the underlying lesion or intima, as well as modifications of shear and tensile forces to which the lesion or intima is exposed. Clinical imaging of lesions may be expected to contribute greatly to the understanding of type VI lesions and the associated clinical syndromes. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVType VI atherosclerotic lesion

Abnormal vascular morphology
- Abnormal blood vessel morphology
  - Abnormal systemic arterial morphology
    - Arteriosclerosis disorder
      - Atherosclerosis
        Atherosclerotic lesion
        Type VI atherosclerotic lesion

Recent clinical studies

Etiology

Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA.

Kopczak A, Schindler A, Sepp D, Bayer-Karpinska A, Malik R, Koch ML, Zeller J, Strecker C, Janowitz D, Wollenweber FA, Hempel JM, Boeckh-Behrens T, Cyran CC, Helck A, Harloff A, Ziemann U, Poli S, Poppert H, Saam T, Dichgans M
J Am Coll Cardiol 2022 Jun 7;79(22):2189-2199. Epub 2022 May 3 doi: 10.1016/j.jacc.2022.03.376. PMID: 35523659

Relationship between Calcification and Vulnerability of the Carotid Plaques.

Pini R, Faggioli G, Fittipaldi S, Vasuri F, Longhi M, Gallitto E, Pasquinelli G, Gargiulo M, Stella A
Ann Vasc Surg 2017 Oct;44:336-342. Epub 2017 May 4 doi: 10.1016/j.avsg.2017.04.017. PMID: 28479433

Histomorphological evaluation of atherosclerotic lesions in patients with peripheral artery occlusive disease.

Zimmermann A, Senner S, Eckstein HH, Pelisek J
Adv Med Sci 2015 Sep;60(2):236-9. Epub 2015 Apr 4 doi: 10.1016/j.advms.2015.03.003. PMID: 25925508

Infections and atherosclerosis.

Leinonen M, Saikku P
Scand Cardiovasc J 2000;34(1):12-20. doi: 10.1080/14017430050142341. PMID: 10816055

Plaque rupture, thrombosis, and therapeutic implications.

Fuster V, Badimon J, Chesebro JH, Fallon JT
Haemostasis 1996 Oct;26 Suppl 4:269-84. doi: 10.1159/000217308. PMID: 8979133

See all (42)

Diagnosis

Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA.

AHA classification of coronary and carotid atherosclerotic plaques by grating-based phase-contrast computed tomography.

Hetterich H, Webber N, Willner M, Herzen J, Birnbacher L, Hipp A, Marschner M, Auweter SD, Habbel C, Schüller U, Bamberg F, Ertl-Wagner B, Pfeiffer F, Saam T
Eur Radiol 2016 Sep;26(9):3223-33. Epub 2015 Dec 17 doi: 10.1007/s00330-015-4143-z. PMID: 26679184

Intra-individual comparison of carotid and femoral atherosclerotic plaque features with in vivo MR plaque imaging.

Helck A, Bianda N, Canton G, Yuan C, Hippe DS, Reiser MF, Gallino A, Wyttenbach R, Saam T
Int J Cardiovasc Imaging 2015 Dec;31(8):1611-8. Epub 2015 Aug 22 doi: 10.1007/s10554-015-0737-4. PMID: 26296806

Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR.

Grimm JM, Schindler A, Freilinger T, Cyran CC, Bamberg F, Yuan C, Reiser MF, Dichgans M, Freilinger C, Nikolaou K, Saam T
J Cardiovasc Magn Reson 2013 May 24;15(1):44. doi: 10.1186/1532-429X-15-44. PMID: 23705576 Free PMC Article

Prevalence of nonstenosing, complicated atherosclerotic plaques in cryptogenic stroke.

Freilinger TM, Schindler A, Schmidt C, Grimm J, Cyran C, Schwarz F, Bamberg F, Linn J, Reiser M, Yuan C, Nikolaou K, Dichgans M, Saam T
JACC Cardiovasc Imaging 2012 Apr;5(4):397-405. doi: 10.1016/j.jcmg.2012.01.012. PMID: 22498329

See all (23)

Therapy

Prevalence of nonstenosing, complicated atherosclerotic plaques in cryptogenic stroke.

Determination of carotid artery atherosclerotic lesion type and distribution in hypercholesterolemic patients with moderate carotid stenosis using noninvasive magnetic resonance imaging.

Chu B, Hatsukami TS, Polissar NL, Zhao XQ, Kraiss LW, Parker DL, Waterton JC, Raichlen JS, Hamar W, Yuan C
Stroke 2004 Nov;35(11):2444-8. Epub 2004 Oct 7 doi: 10.1161/01.STR.0000144686.57135.98. PMID: 15472094

Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging.

Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, Yuan C
Circulation 2002 Sep 10;106(11):1368-73. doi: 10.1161/01.cir.0000028591.44554.f9. PMID: 12221054

Infections and atherosclerosis.

Leinonen M, Saikku P
Scand Cardiovasc J 2000;34(1):12-20. doi: 10.1080/14017430050142341. PMID: 10816055

Plaque rupture, thrombosis, and therapeutic implications.

Fuster V, Badimon J, Chesebro JH, Fallon JT
Haemostasis 1996 Oct;26 Suppl 4:269-84. doi: 10.1159/000217308. PMID: 8979133

See all (13)

Prognosis

Neutrophil Gelatinase Associated Lipocalin (NGAL) for Identification of Unstable Plaques in Patients with Asymptomatic Carotid Stenosis.

Eilenberg W, Stojkovic S, Kaider A, Piechota-Polanczyk A, Nanobachvili J, Domenig CM, Wojta J, Huk I, Demyanets S, Neumayer C
Eur J Vasc Endovasc Surg 2019 Jun;57(6):768-777. Epub 2019 Jun 1 doi: 10.1016/j.ejvs.2018.12.029. PMID: 31164272

AHA classification of coronary and carotid atherosclerotic plaques by grating-based phase-contrast computed tomography.

Intra-individual comparison of carotid and femoral atherosclerotic plaque features with in vivo MR plaque imaging.

CTA for screening of complicated atherosclerotic carotid plaque--American Heart Association type VI lesions as defined by MRI.

Trelles M, Eberhardt KM, Buchholz M, Schindler A, Bayer-Karpinska A, Dichgans M, Reiser MF, Nikolaou K, Saam T
AJNR Am J Neuroradiol 2013 Dec;34(12):2331-7. Epub 2013 Jul 18 doi: 10.3174/ajnr.A3607. PMID: 23868157 Free PMC Article

Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR.

See all (15)

Clinical prediction guides

Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis.

Zernecke A, Erhard F, Weinberger T, Schulz C, Ley K, Saliba AE, Cochain C
Cardiovasc Res 2023 Jul 6;119(8):1676-1689. doi: 10.1093/cvr/cvac161. PMID: 36190844 Free PMC Article

Multi-contrast and three-dimensional assessment of the aortic wall using 3T MRI.

Wehrum T, Dragonu I, Strecker C, Hennig J, Harloff A
Eur J Radiol 2017 Jun;91:148-154. Epub 2017 Apr 17 doi: 10.1016/j.ejrad.2017.04.011. PMID: 28629561

AHA classification of coronary and carotid atherosclerotic plaques by grating-based phase-contrast computed tomography.

Intra-individual comparison of carotid and femoral atherosclerotic plaque features with in vivo MR plaque imaging.

Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR.

See all (28)