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Mediastinal Granulocytic Sarcoma

MedGen UID:
1644199
•Concept ID:
C4687536
•
Neoplastic Process

Definition

A malignant tumor that arises from the mediastinum and is composed of myeloblasts, neutrophils and neutrophil precursors. It is the most common type of myeloid sarcoma affecting the mediastinum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal Granulocytic Sarcoma

Recent clinical studies

Etiology

Mediastinal granulocytic sarcoma: poor risk AML?
Gogia A, Sharma A, Chopra A, Kumar R
J Indian Med Assoc 2013 Aug;111(8):562. PMID: 24783400
Near tetraploidy in three cases of acute myeloid leukemia associated with mediastinal granulocytic sarcoma.
Au WY, Ma SK, Chan AC, Liang R, Lam CC, Kwong YL
Cancer Genet Cytogenet 1998 Apr 1;102(1):50-3. doi: 10.1016/s0165-4608(97)00294-x. PMID: 9530340
Acute myelogenous leukemia associated with a mediastinal tumor.
Chubachi A, Miura I, Takahashi N, Nimura T, Imai H, Miura AB
Leuk Lymphoma 1993 Dec;12(1-2):143-6. doi: 10.3109/10428199309059583. PMID: 8161930

Diagnosis

Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome.
Tsai MH, Yang CP, Chung HT, Shih LY
J Pediatr Hematol Oncol 2009 Dec;31(12):980-2. doi: 10.1097/MPH.0b013e3181b86ff3. PMID: 19956024
Resection of mediastinal granulocytic sarcoma triggered the rapid progression of acute myeloid leukemia.
Suemitsu R, Fukuyama S, Ondo K, Ueda H
Ann Thorac Cardiovasc Surg 2008 Jun;14(3):181-3. PMID: 18577899
Mediastinal granulocytic sarcoma: a report of two cases.
McCluggage WG, Boyd HK, Jones FG, Mayne EE, Bharucha H
Arch Pathol Lab Med 1998 Jun;122(6):545-7. PMID: 9625423
Acute myelogenous leukemia associated with a mediastinal tumor.
Chubachi A, Miura I, Takahashi N, Nimura T, Imai H, Miura AB
Leuk Lymphoma 1993 Dec;12(1-2):143-6. doi: 10.3109/10428199309059583. PMID: 8161930
Granulocytic sarcoma presenting as a mediastinal tumor. Report of a case and cytological and cytochemical studies of tumor cells in vivo and in vitro.
Kubonishi I, Ohtsuki Y, Machida K, Agatsuma Y, Tokuoka H, Iwata K, Miyoshi I
Am J Clin Pathol 1984 Dec;82(6):730-4. doi: 10.1093/ajcp/82.6.730. PMID: 6594928

Therapy

Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome.
Tsai MH, Yang CP, Chung HT, Shih LY
J Pediatr Hematol Oncol 2009 Dec;31(12):980-2. doi: 10.1097/MPH.0b013e3181b86ff3. PMID: 19956024
Resection of mediastinal granulocytic sarcoma triggered the rapid progression of acute myeloid leukemia.
Suemitsu R, Fukuyama S, Ondo K, Ueda H
Ann Thorac Cardiovasc Surg 2008 Jun;14(3):181-3. PMID: 18577899
Acute myelogenous leukemia associated with a mediastinal tumor.
Chubachi A, Miura I, Takahashi N, Nimura T, Imai H, Miura AB
Leuk Lymphoma 1993 Dec;12(1-2):143-6. doi: 10.3109/10428199309059583. PMID: 8161930

Prognosis

Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome.
Tsai MH, Yang CP, Chung HT, Shih LY
J Pediatr Hematol Oncol 2009 Dec;31(12):980-2. doi: 10.1097/MPH.0b013e3181b86ff3. PMID: 19956024
Resection of mediastinal granulocytic sarcoma triggered the rapid progression of acute myeloid leukemia.
Suemitsu R, Fukuyama S, Ondo K, Ueda H
Ann Thorac Cardiovasc Surg 2008 Jun;14(3):181-3. PMID: 18577899
Mediastinal granulocytic sarcoma: a report of two cases.
McCluggage WG, Boyd HK, Jones FG, Mayne EE, Bharucha H
Arch Pathol Lab Med 1998 Jun;122(6):545-7. PMID: 9625423
Acute myelogenous leukemia associated with a mediastinal tumor.
Chubachi A, Miura I, Takahashi N, Nimura T, Imai H, Miura AB
Leuk Lymphoma 1993 Dec;12(1-2):143-6. doi: 10.3109/10428199309059583. PMID: 8161930

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