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Impaired nasal mucociliary clearance

MedGen UID:
1640666
•Concept ID:
C4703436
•
Finding
Synonym: Abnormal saccharine test
 
HPO: HP:0031603

Definition

An abnormally increased amount of time required to clear mucus (and substances contained in the mucus) from the nasal mucosa. The nasal mucociliary clearance (NMC) system functions to transport the mucous layer lining the nasal epithelium towards the naso pharynx by ciliary beating in a metachronous fashion at a frequency of 7-16 Hz. NMC depends upon two principal components [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired nasal mucociliary clearance

Conditions with this feature

Ciliary dyskinesia, primary, 41
MedGen UID:
1680404
•Concept ID:
C5193103
•
Disease or Syndrome
Ciliary dyskinesia-41 (CILD41) is an autosomal recessive disorder characterized by chronic sinusitis, otitis media, and bronchiectasis (Bustamante-Marin et al., 2019). For a phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).
See: Condition Record
Ciliary dyskinesia, primary, 41

Professional guidelines

PubMed

Updated epithelial barrier dysfunction in chronic rhinosinusitis: Targeting pathophysiology and treatment response of tight junctions.
Huang ZQ, Liu J, Sun LY, Ong HH, Ye J, Xu Y, Wang DY
Allergy 2024 May;79(5):1146-1165. Epub 2024 Feb 19 doi: 10.1111/all.16064. PMID: 38372149
Bacteriology and treatment of infections in the upper and lower airways in patients with primary ciliary dyskinesia: adressing the paranasal sinuses.
Alanin MC
Dan Med J 2017 May;64(5) PMID: 28552099
Primary ciliary dyskinesia: recent advances in pathogenesis, diagnosis and treatment.
Lie H, Ferkol T
Drugs 2007;67(13):1883-92. doi: 10.2165/00003495-200767130-00006. PMID: 17722956

Recent clinical studies

Etiology

Aerobic exercise in polluted urban environments: effects on airway defense mechanisms in young healthy amateur runners.
Cavalcante de Sá M, Nakagawa NK, Saldiva de André CD, Carvalho-Oliveira R, de Santana Carvalho T, Nicola ML, de André PA, Nascimento Saldiva PH, Vaisberg M
J Breath Res 2016 Dec 21;10(4):046018. doi: 10.1088/1752-7163/10/4/046018. PMID: 28000620
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation.
Utiyama DM, Yoshida CT, Goto DM, de Santana Carvalho T, de Paula Santos U, Koczulla AR, Saldiva PH, Nakagawa NK
Clinics (Sao Paulo) 2016 Jul;71(6):344-50. doi: 10.6061/clinics/2016(06)10. PMID: 27438569Free PMC Article
Reversibility of impaired nasal mucociliary clearance in smokers following a smoking cessation programme.
Ramos EM, De Toledo AC, Xavier RF, Fosco LC, Vieira RP, Ramos D, Jardim JR
Respirology 2011 Jul;16(5):849-55. doi: 10.1111/j.1440-1843.2011.01985.x. PMID: 21545372
Impaired nasal mucociliary clearance in long-distance runners.
Müns G, Singer P, Wolf F, Rubinstein I
Int J Sports Med 1995 May;16(4):209-13. doi: 10.1055/s-2007-972993. PMID: 7657412

Diagnosis

Immotile-cilia syndrome with azoospermia: a case report and review of the literature.
Bashi S, Khan MA, Guirjis A, Joharjy IA, Abid MA
Br J Dis Chest 1988 Apr;82(2):194-6. doi: 10.1016/0007-0971(88)90043-5. PMID: 3048367

Therapy

Aerobic exercise in polluted urban environments: effects on airway defense mechanisms in young healthy amateur runners.
Cavalcante de Sá M, Nakagawa NK, Saldiva de André CD, Carvalho-Oliveira R, de Santana Carvalho T, Nicola ML, de André PA, Nascimento Saldiva PH, Vaisberg M
J Breath Res 2016 Dec 21;10(4):046018. doi: 10.1088/1752-7163/10/4/046018. PMID: 28000620
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation.
Utiyama DM, Yoshida CT, Goto DM, de Santana Carvalho T, de Paula Santos U, Koczulla AR, Saldiva PH, Nakagawa NK
Clinics (Sao Paulo) 2016 Jul;71(6):344-50. doi: 10.6061/clinics/2016(06)10. PMID: 27438569Free PMC Article
Reversibility of impaired nasal mucociliary clearance in smokers following a smoking cessation programme.
Ramos EM, De Toledo AC, Xavier RF, Fosco LC, Vieira RP, Ramos D, Jardim JR
Respirology 2011 Jul;16(5):849-55. doi: 10.1111/j.1440-1843.2011.01985.x. PMID: 21545372
Work related impairment of nasal function in Swedish woodwork teachers.
Ahman M, Holmström M, Cynkier I, Söderman E
Occup Environ Med 1996 Feb;53(2):112-7. doi: 10.1136/oem.53.2.112. PMID: 8777447Free PMC Article
Measurement of nasal mucociliary clearance.
Corbo GM, Foresi A, Bonfitto P, Mugnano A, Agabiti N, Cole PJ
Arch Dis Child 1989 Apr;64(4):546-50. doi: 10.1136/adc.64.4.546. PMID: 2751328Free PMC Article

Prognosis

Reversibility of impaired nasal mucociliary clearance in smokers following a smoking cessation programme.
Ramos EM, De Toledo AC, Xavier RF, Fosco LC, Vieira RP, Ramos D, Jardim JR
Respirology 2011 Jul;16(5):849-55. doi: 10.1111/j.1440-1843.2011.01985.x. PMID: 21545372

Clinical prediction guides

The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation.
Utiyama DM, Yoshida CT, Goto DM, de Santana Carvalho T, de Paula Santos U, Koczulla AR, Saldiva PH, Nakagawa NK
Clinics (Sao Paulo) 2016 Jul;71(6):344-50. doi: 10.6061/clinics/2016(06)10. PMID: 27438569Free PMC Article
Impaired nasal mucociliary clearance in long-distance runners.
Müns G, Singer P, Wolf F, Rubinstein I
Int J Sports Med 1995 May;16(4):209-13. doi: 10.1055/s-2007-972993. PMID: 7657412

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