U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Defective interstrand cross-link repair

MedGen UID:
1639795
•Concept ID:
C4703653
•
Cell or Molecular Dysfunction
HPO: HP:0410166

Definition

A defect in the of the process of interstrand cross-link repair [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDefective interstrand cross-link repair

Recent clinical studies

Etiology

Current and emerging roles of Cockayne syndrome group B (CSB) protein.
Tiwari V, Baptiste BA, Okur MN, Bohr VA
Nucleic Acids Res 2021 Mar 18;49(5):2418-2434. doi: 10.1093/nar/gkab085. PMID: 33590097Free PMC Article
Emerging functions of Fanconi anemia genes in replication fork protection pathways.
Kolinjivadi AM, Crismani W, Ngeow J
Hum Mol Genet 2020 Oct 20;29(R2):R158-R164. doi: 10.1093/hmg/ddaa087. PMID: 32420592
Holding All the Cards-How Fanconi Anemia Proteins Deal with Replication Stress and Preserve Genomic Stability.
Datta A, Brosh RM Jr
Genes (Basel) 2019 Feb 22;10(2) doi: 10.3390/genes10020170. PMID: 30813363Free PMC Article
Spectrin and its interacting partners in nuclear structure and function.
Lambert MW
Exp Biol Med (Maywood) 2018 Mar;243(6):507-524. doi: 10.1177/1535370218763563. PMID: 29557213Free PMC Article
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway.
Kim H, D'Andrea AD
Genes Dev 2012 Jul 1;26(13):1393-408. doi: 10.1101/gad.195248.112. PMID: 22751496Free PMC Article

Diagnosis

Emerging functions of Fanconi anemia genes in replication fork protection pathways.
Kolinjivadi AM, Crismani W, Ngeow J
Hum Mol Genet 2020 Oct 20;29(R2):R158-R164. doi: 10.1093/hmg/ddaa087. PMID: 32420592
Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging.
Brosh RM Jr, Bellani M, Liu Y, Seidman MM
Ageing Res Rev 2017 Jan;33:67-75. Epub 2016 May 17 doi: 10.1016/j.arr.2016.05.005. PMID: 27223997Free PMC Article
Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity.
Kothandapani A, Sawant A, Dangeti VS, Sobol RW, Patrick SM
Nucleic Acids Res 2013 Aug;41(15):7332-43. Epub 2013 Jun 12 doi: 10.1093/nar/gkt479. PMID: 23761438Free PMC Article
Removal of reactive oxygen species-induced 3'-blocked ends by XPF-ERCC1.
Fisher LA, Samson L, Bessho T
Chem Res Toxicol 2011 Nov 21;24(11):1876-81. Epub 2011 Oct 18 doi: 10.1021/tx200221j. PMID: 22007867Free PMC Article
DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts.
Mu D, Bessho T, Nechev LV, Chen DJ, Harris TM, Hearst JE, Sancar A
Mol Cell Biol 2000 Apr;20(7):2446-54. doi: 10.1128/MCB.20.7.2446-2454.2000. PMID: 10713168Free PMC Article

Therapy

Mechanism-based design of agents that selectively target drug-resistant glioma.
Lin K, Gueble SE, Sundaram RK, Huseman ED, Bindra RS, Herzon SB
Science 2022 Jul 29;377(6605):502-511. Epub 2022 Jul 28 doi: 10.1126/science.abn7570. PMID: 35901163Free PMC Article
Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy.
Jo U, Kim H
Mol Cells 2015 Aug;38(8):669-76. Epub 2015 Jul 21 doi: 10.14348/molcells.2015.0175. PMID: 26194820Free PMC Article
USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.
Perez-Oliva AB, Lachaud C, Szyniarowski P, Muñoz I, Macartney T, Hickson I, Rouse J, Alessi DR
EMBO J 2015 Feb 3;34(3):326-43. Epub 2014 Dec 23 doi: 10.15252/embj.201489184. PMID: 25538220Free PMC Article
Removal of reactive oxygen species-induced 3'-blocked ends by XPF-ERCC1.
Fisher LA, Samson L, Bessho T
Chem Res Toxicol 2011 Nov 21;24(11):1876-81. Epub 2011 Oct 18 doi: 10.1021/tx200221j. PMID: 22007867Free PMC Article
DNA interstrand cross-linking, repair, and SCE mechanism in human cells in special reference to Fanconi anemia.
Fujiwara Y, Kano Y, Yamamoto Y
Basic Life Sci 1984;29 Pt B:787-800. doi: 10.1007/978-1-4684-4892-4_21. PMID: 6442145

Prognosis

Current and emerging roles of Cockayne syndrome group B (CSB) protein.
Tiwari V, Baptiste BA, Okur MN, Bohr VA
Nucleic Acids Res 2021 Mar 18;49(5):2418-2434. doi: 10.1093/nar/gkab085. PMID: 33590097Free PMC Article
Nuclear α Spectrin Differentially Affects Monoubiquitinated Versus Non-Ubiquitinated FANCD2 Function After DNA Interstrand Cross-Link Damage.
Zhang P, Sridharan D, Lambert MW
J Cell Biochem 2016 Mar;117(3):671-83. Epub 2015 Sep 9 doi: 10.1002/jcb.25352. PMID: 26297932

Clinical prediction guides

Current and emerging roles of Cockayne syndrome group B (CSB) protein.
Tiwari V, Baptiste BA, Okur MN, Bohr VA
Nucleic Acids Res 2021 Mar 18;49(5):2418-2434. doi: 10.1093/nar/gkab085. PMID: 33590097Free PMC Article
PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication.
Lin YC, Wang Y, Hsu R, Giri S, Wopat S, Arif MK, Chakraborty A, Prasanth KV, Prasanth SG
Proc Natl Acad Sci U S A 2018 Dec 26;115(52):13282-13287. Epub 2018 Dec 10 doi: 10.1073/pnas.1814521115. PMID: 30530694Free PMC Article
Spectrin and its interacting partners in nuclear structure and function.
Lambert MW
Exp Biol Med (Maywood) 2018 Mar;243(6):507-524. doi: 10.1177/1535370218763563. PMID: 29557213Free PMC Article
Removal of reactive oxygen species-induced 3'-blocked ends by XPF-ERCC1.
Fisher LA, Samson L, Bessho T
Chem Res Toxicol 2011 Nov 21;24(11):1876-81. Epub 2011 Oct 18 doi: 10.1021/tx200221j. PMID: 22007867Free PMC Article
DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts.
Mu D, Bessho T, Nechev LV, Chen DJ, Harris TM, Hearst JE, Sancar A
Mol Cell Biol 2000 Apr;20(7):2446-54. doi: 10.1128/MCB.20.7.2446-2454.2000. PMID: 10713168Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...