Type V atherosclerotic lesion

MedGen UID:: 1638264
•Concept ID:: C4703477
•: Disease or Syndrome

HPO:	HP:0031682

Definition

Type V lesions are defined as lesions in which prominent new fibrous connective tissue has formed. When the new tissue is part of a lesion with a lipid core (type IV), this type of morphology may be referred to as fibroatheroma or type Va lesion. A type V lesion in which the lipid core and other parts of the lesion are calcified may be referred to as type Vb. A type V lesion in which a lipid core is absent and lipid in general is minimal may be referred to as type Vc. With these lesions, arteries are variously narrowed, generally more than with type IV. Importantly, as with type IV lesions, type V lesions may develop fissures, hematoma, and/or thrombus (type VI lesion), and for this reason too they are clinically relevant. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVType V atherosclerotic lesion

Abnormal vascular morphology
- Abnormal blood vessel morphology
  - Abnormal systemic arterial morphology
    - Arteriosclerosis disorder
      - Atherosclerosis
        Atherosclerotic lesion
        Type V atherosclerotic lesion

Recent clinical studies

Etiology

Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.

Kothari V, Ho TWW, Cabodevilla AG, He Y, Kramer F, Shimizu-Albergine M, Kanter JE, Snell-Bergeon J, Fisher EA, Shao B, Heinecke JW, Wobbrock JO, Lee WL, Goldberg IJ, Vaisar T, Bornfeldt KE
Circ Res 2024 Jul 5;135(2):335-349. Epub 2024 Jun 3 doi: 10.1161/CIRCRESAHA.123.323100. PMID: 38828596 Free PMC Article

Features of Carotid Endarterectomy in Russia. How do we Resolution Issues?

Belov YV, Kazantsev AN, Kravchuk VN, Vinogradov RA, Korotkikh AV, Shmatov DV, Chernykh KP, Zakeryaev AB, Sukhoruchkin PV, Matusevich VV, Yu Lider R, Kazantseva EG, Zakharova CL, Sh Bagdavadze G, Zharova AS, Artyukhov SV, Lutsenko VA, Sultanov RV
Curr Probl Cardiol 2022 Sep;47(9):101272. Epub 2022 May 27 doi: 10.1016/j.cpcardiol.2022.101272. PMID: 35644499

Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Nonculprit Lesions.

Kurihara O, Okajima F, Takano M, Kato K, Munakata R, Murakami D, Miyauchi Y, Emoto N, Sugihara H, Seino Y, Shimizu W
Arterioscler Thromb Vasc Biol 2018 Aug;38(8):1940-1947. doi: 10.1161/ATVBAHA.118.311245. PMID: 29930008

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis.

Westerterp M, Fotakis P, Ouimet M, Bochem AE, Zhang H, Molusky MM, Wang W, Abramowicz S, la Bastide-van Gemert S, Wang N, Welch CL, Reilly MP, Stroes ES, Moore KJ, Tall AR
Circulation 2018 Aug 28;138(9):898-912. doi: 10.1161/CIRCULATIONAHA.117.032636. PMID: 29588315 Free PMC Article

Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.

Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890 Free PMC Article

See all (40)

Diagnosis

Lipid-lowering Therapy and Coronary Plaque Regression.

Ueki Y, Itagaki T, Kuwahara K
J Atheroscler Thromb 2024 Nov 1;31(11):1479-1495. Epub 2024 Aug 8 doi: 10.5551/jat.RV22024. PMID: 39111840 Free PMC Article

Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery.

Yu M, Ortega CA, Si K, Molinaro R, Schoen FJ, Leitao RFC, Xu X, Mahmoudi M, Ahn S, Liu J, Saw PE, Lee IH, Brayner MMB, Lotfi A, Shi J, Libby P, Jon S, Farokhzad OC
Theranostics 2018;8(21):6008-6024. Epub 2018 Nov 15 doi: 10.7150/thno.24365. PMID: 30613278 Free PMC Article

Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Nonculprit Lesions.

AHA classification of coronary and carotid atherosclerotic plaques by grating-based phase-contrast computed tomography.

Hetterich H, Webber N, Willner M, Herzen J, Birnbacher L, Hipp A, Marschner M, Auweter SD, Habbel C, Schüller U, Bamberg F, Ertl-Wagner B, Pfeiffer F, Saam T
Eur Radiol 2016 Sep;26(9):3223-33. Epub 2015 Dec 17 doi: 10.1007/s00330-015-4143-z. PMID: 26679184

Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.

Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M
Circ Res 2015 Oct 23;117(10):835-45. Epub 2015 Sep 22 doi: 10.1161/CIRCRESAHA.115.307024. PMID: 26394773 Free PMC Article

See all (25)

Therapy

Lipid-lowering Therapy and Coronary Plaque Regression.

Ueki Y, Itagaki T, Kuwahara K
J Atheroscler Thromb 2024 Nov 1;31(11):1479-1495. Epub 2024 Aug 8 doi: 10.5551/jat.RV22024. PMID: 39111840 Free PMC Article

Ca(v)3.1 T-type calcium channel blocker NNC 55-0396 reduces atherosclerosis by increasing cholesterol efflux.

Tsai MC, Cho RL, Lin CS, Jheng YS, Lien CF, Chen CC, Tzeng BH
Biochem Pharmacol 2024 Apr;222:116096. Epub 2024 Feb 27 doi: 10.1016/j.bcp.2024.116096. PMID: 38423188

Features of Carotid Endarterectomy in Russia. How do we Resolution Issues?

Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial.

Räber L, Ueki Y, Otsuka T, Losdat S, Häner JD, Lonborg J, Fahrni G, Iglesias JF, van Geuns RJ, Ondracek AS, Radu Juul Jensen MD, Zanchin C, Stortecky S, Spirk D, Siontis GCM, Saleh L, Matter CM, Daemen J, Mach F, Heg D, Windecker S, Engstrøm T, Lang IM, Koskinas KC; PACMAN-AMI collaborators
JAMA 2022 May 10;327(18):1771-1781. doi: 10.1001/jama.2022.5218. PMID: 35368058 Free PMC Article

Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages.

Rinne P, Rami M, Nuutinen S, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki T, Weber C, Steffens S
Circulation 2017 Jul 4;136(1):83-97. Epub 2017 Apr 27 doi: 10.1161/CIRCULATIONAHA.116.025889. PMID: 28450348 Free PMC Article

See all (24)

Prognosis

Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.

Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Nonculprit Lesions.

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.

Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D
Circ Res 2018 Jun 8;122(12):1675-1688. Epub 2018 Mar 15 doi: 10.1161/CIRCRESAHA.117.312513. PMID: 29545366 Free PMC Article

Potential Role for Dendritic Cells in Endothelial Dysfunction, Diabetes and Cardiovascular Disease.

Parenti A, Pala L, Paccosi S, Rotella CM
Curr Pharm Des 2017;23(10):1435-1444. doi: 10.2174/1381612823666170124125826. PMID: 28120714

Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.

See all (21)