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Viral respiratory tract infection

MedGen UID:
163755
•Concept ID:
C0877203
•
Disease or Syndrome
Synonyms: Viral Respiratory Tract Infection; viral respiratory tract infection
 
Monarch Initiative: MONDO:0024352

Definition

A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus. [from NCI]

Professional guidelines

PubMed

Effects of select dietary supplements on the prevention and treatment of viral respiratory tract infections: a systematic review of randomized controlled trials.
Shokri-Mashhadi N, Kazemi M, Saadat S, Moradi S
Expert Rev Respir Med 2021 Jun;15(6):805-821. Epub 2021 Apr 26 doi: 10.1080/17476348.2021.1918546. PMID: 33858268
Issues in the management of bacterial sinusitis.
Bishai WR
Otolaryngol Head Neck Surg 2002 Dec;127(6 Suppl):S3-9. doi: 10.1067/mhn.2002.130030. PMID: 12511854
Management of bronchiolitis.
Nahata MC, Johnson JA, Powell DA
Clin Pharm 1985 May-Jun;4(3):297-303. PMID: 3891201

Recent clinical studies

Etiology

Nebulised 3% hypertonic saline versus 0.9% saline for treating patients hospitalised with acute bronchiolitis: protocol for a randomised, double-blind, multicentre trial.
Szupieńko S, Buczek A, Szymański H
BMJ Open 2023 Nov 27;13(11):e080182. doi: 10.1136/bmjopen-2023-080182. PMID: 38011984Free PMC Article
Viral Respiratory Tract Infections in Allogeneic Hematopoietic Stem Cell Transplantation Recipients in the Era of Molecular Testing.
Sim SA, Leung VKY, Ritchie D, Slavin MA, Sullivan SG, Teh BW
Biol Blood Marrow Transplant 2018 Jul;24(7):1490-1496. Epub 2018 Mar 9 doi: 10.1016/j.bbmt.2018.03.004. PMID: 29530766Free PMC Article
Viral respiratory tract infections and asthma in early life: cause and effect?
Mackenzie KJ, Anderton SM, Schwarze J
Clin Exp Allergy 2014 Jan;44(1):9-19. doi: 10.1111/cea.12246. PMID: 24355020
Viral infection of the lung: host response and sequelae.
Yoo JK, Kim TS, Hufford MM, Braciale TJ
J Allergy Clin Immunol 2013 Dec;132(6):1263-76; quiz 1277. Epub 2013 Aug 1 doi: 10.1016/j.jaci.2013.06.006. PMID: 23915713Free PMC Article
Current therapy for bronchiolitis.
Nagakumar P, Doull I
Arch Dis Child 2012 Sep;97(9):827-30. Epub 2012 Jun 25 doi: 10.1136/archdischild-2011-301579. PMID: 22734014

Diagnosis

Nebulised 3% hypertonic saline versus 0.9% saline for treating patients hospitalised with acute bronchiolitis: protocol for a randomised, double-blind, multicentre trial.
Szupieńko S, Buczek A, Szymański H
BMJ Open 2023 Nov 27;13(11):e080182. doi: 10.1136/bmjopen-2023-080182. PMID: 38011984Free PMC Article
Subacute Thyroiditis in COVID-19 Patients.
Seyed Resuli A, Bezgal M
Ear Nose Throat J 2022 Sep;101(8):501-505. Epub 2021 May 11 doi: 10.1177/01455613211012114. PMID: 33974811
Viral coinfections in COVID-19.
Aghbash PS, Eslami N, Shirvaliloo M, Baghi HB
J Med Virol 2021 Sep;93(9):5310-5322. Epub 2021 Jun 12 doi: 10.1002/jmv.27102. PMID: 34032294Free PMC Article
Bronchiectasis, Chronic Suppurative Lung Disease and Protracted Bacterial Bronchitis.
Benscoter DT
Curr Probl Pediatr Adolesc Health Care 2018 Apr;48(4):119-123. Epub 2018 Mar 27 doi: 10.1016/j.cppeds.2018.03.003. PMID: 29602647
Exacerbation of asthma and airway infection: is the virus the villain?
Costa LD, Costa PS, Camargos PA
J Pediatr (Rio J) 2014 Nov-Dec;90(6):542-55. Epub 2014 Sep 26 doi: 10.1016/j.jped.2014.07.001. PMID: 25261603Free PMC Article

Therapy

Nebulised 3% hypertonic saline versus 0.9% saline for treating patients hospitalised with acute bronchiolitis: protocol for a randomised, double-blind, multicentre trial.
Szupieńko S, Buczek A, Szymański H
BMJ Open 2023 Nov 27;13(11):e080182. doi: 10.1136/bmjopen-2023-080182. PMID: 38011984Free PMC Article
Viral Respiratory Tract Infections in Allogeneic Hematopoietic Stem Cell Transplantation Recipients in the Era of Molecular Testing.
Sim SA, Leung VKY, Ritchie D, Slavin MA, Sullivan SG, Teh BW
Biol Blood Marrow Transplant 2018 Jul;24(7):1490-1496. Epub 2018 Mar 9 doi: 10.1016/j.bbmt.2018.03.004. PMID: 29530766Free PMC Article
Where did the salt go?
Paul SP, Hicks SS, Sanjeevaiah MK, Heaton PA
Turk J Pediatr 2017;59(3):345-348. doi: 10.24953/turkjped.2017.03.020. PMID: 29376584
Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children.
Brodlie M, Gupta A, Rodriguez-Martinez CE, Castro-Rodriguez JA, Ducharme FM, McKean MC
Cochrane Database Syst Rev 2015 Oct 19;2015(10):CD008202. doi: 10.1002/14651858.CD008202.pub2. PMID: 26482324Free PMC Article
Current therapy for bronchiolitis.
Nagakumar P, Doull I
Arch Dis Child 2012 Sep;97(9):827-30. Epub 2012 Jun 25 doi: 10.1136/archdischild-2011-301579. PMID: 22734014

Prognosis

Investigation of human bocavirus in pediatric patients with respiratory tract infection.
Bakir A, Karabulut N, Alacam S, Mese S, Somer A, Agacfidan A
J Infect Dev Ctries 2020 Oct 31;14(10):1191-1196. doi: 10.3855/jidc.12553. PMID: 33175716
Bronchiectasis, Chronic Suppurative Lung Disease and Protracted Bacterial Bronchitis.
Benscoter DT
Curr Probl Pediatr Adolesc Health Care 2018 Apr;48(4):119-123. Epub 2018 Mar 27 doi: 10.1016/j.cppeds.2018.03.003. PMID: 29602647
Clinical practice: immune thrombocytopenia in paediatrics.
Labarque V, Van Geet C
Eur J Pediatr 2014 Feb;173(2):163-72. Epub 2014 Jan 5 doi: 10.1007/s00431-013-2254-6. PMID: 24390128
Translating the role of vitamin D3 in infectious diseases.
Khoo AL, Chai L, Koenen H, Joosten I, Netea M, van der Ven A
Crit Rev Microbiol 2012 May;38(2):122-35. Epub 2012 Feb 5 doi: 10.3109/1040841X.2011.622716. PMID: 22304022
Fever of unknown origin: a diagnostic approach to this vexing problem.
Tolan RW Jr
Clin Pediatr (Phila) 2010 Mar;49(3):207-13. doi: 10.1177/0009922809347799. PMID: 20164070

Clinical prediction guides

Immunoglobulin A Vasculitis Following COVID-19: A French Multicenter Case Series.
Ramdani Y, Galempoix JM, Augusto JF, Dekmeer E, Perard L, Ferreira N, Bigot A, Magnant J, Jobard S, Diot E, Besse MC, Henrique H, Maillot F, Audemard-Verger A
J Rheumatol 2022 Dec;49(12):1390-1394. Epub 2022 Sep 1 doi: 10.3899/jrheum.220503. PMID: 36243405
Changes in paediatric respiratory infections at a UK teaching hospital 2016-2021; impact of the SARS-CoV-2 pandemic.
Lumley SF, Richens N, Lees E, Cregan J, Kalimeris E, Oakley S, Morgan M, Segal S, Dawson M, Walker AS, Eyre DW, Crook DW, Beer S, Novak A, Stoesser NE, Matthews PC
J Infect 2022 Jan;84(1):40-47. Epub 2021 Oct 29 doi: 10.1016/j.jinf.2021.10.022. PMID: 34757137Free PMC Article
Clinical practice: immune thrombocytopenia in paediatrics.
Labarque V, Van Geet C
Eur J Pediatr 2014 Feb;173(2):163-72. Epub 2014 Jan 5 doi: 10.1007/s00431-013-2254-6. PMID: 24390128
Recent advances in otitis media.
Pelton SI, Leibovitz E
Pediatr Infect Dis J 2009 Oct;28(10 Suppl):S133-7. doi: 10.1097/INF.0b013e3181b6d81a. PMID: 19918136
Viral respiratory tract infection and exacerbations of asthma in adult patients.
Beasley R, Coleman ED, Hermon Y, Holst PE, O'Donnell TV, Tobias M
Thorax 1988 Sep;43(9):679-83. doi: 10.1136/thx.43.9.679. PMID: 3194873Free PMC Article

Recent systematic reviews

Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
Vlieg-Boerstra B, de Jong N, Meyer R, Agostoni C, De Cosmi V, Grimshaw K, Milani GP, Muraro A, Oude Elberink H, Pali-Schöll I, Roduit C, Sasaki M, Skypala I, Sokolowska M, van Splunter M, Untersmayr E, Venter C, O'Mahony L, Nwaru BI
Allergy 2022 May;77(5):1373-1388. Epub 2021 Oct 27 doi: 10.1111/all.15136. PMID: 34626488
Effects of select dietary supplements on the prevention and treatment of viral respiratory tract infections: a systematic review of randomized controlled trials.
Shokri-Mashhadi N, Kazemi M, Saadat S, Moradi S
Expert Rev Respir Med 2021 Jun;15(6):805-821. Epub 2021 Apr 26 doi: 10.1080/17476348.2021.1918546. PMID: 33858268
Role of Probiotics in Stimulating the Immune System in Viral Respiratory Tract Infections: A Narrative Review.
Lehtoranta L, Latvala S, Lehtinen MJ
Nutrients 2020 Oct 16;12(10) doi: 10.3390/nu12103163. PMID: 33081138Free PMC Article
Tiotropium in children and adolescents with asthma.
Murphy KR, Chipps BE
Ann Allergy Asthma Immunol 2020 Mar;124(3):267-276.e3. Epub 2019 Dec 2 doi: 10.1016/j.anai.2019.11.030. PMID: 31805357
Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children.
Brodlie M, Gupta A, Rodriguez-Martinez CE, Castro-Rodriguez JA, Ducharme FM, McKean MC
Cochrane Database Syst Rev 2015 Oct 19;2015(10):CD008202. doi: 10.1002/14651858.CD008202.pub2. PMID: 26482324Free PMC Article

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