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Skin Nodulo-Ulcerative Basal Cell Carcinoma

MedGen UID:
163677
•Concept ID:
C0862887
•
Neoplastic Process
Synonyms: Nodulo-Ulcerative Basal Cell Carcinoma; Nodulo-ulcerative basal cell carcinoma; Rodent Ulcer
SNOMED CT: Nodulo-ulcerative basal cell carcinoma (403911008)

Definition

A type of basal cell carcinoma of the skin. It appears as a flesh-colored papule with telangiectatic vessels on its surface. It grows slowly; as it enlarges it becomes necrotic forming a central ulcer with raised borders. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Nodulo-Ulcerative Basal Cell Carcinoma

Recent clinical studies

Etiology

Use of preoperative and perioperative ex vivo dermoscopy for precise mapping of margins for standard surgical excision of primary basal cell carcinoma.
Savant SS Jr
Indian J Dermatol Venereol Leprol 2023 Sep-Oct;89(5):793. doi: 10.25259/IJDVL_325_2022. PMID: 37317762
Optimizing the effective doses of mitomycin C, 5-fluorouracil, and their combination on cultivated basal cell carcinoma.
Balagholi S, Aletaha M, Kanavi MR, Karami S, Dabbaghi R, Nakhaie PA
Arq Bras Oftalmol 2021;84(5):481-489. Epub 2021 Feb 3 doi: 10.5935/0004-2749.20210049. PMID: 33567038
Langerhans Cell Histiocytosis Presenting as a Nodulo-Ulcerative Eyelid Lesion.
Lo C, Patel P, Charles NC
Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3S Suppl 1):S51-S52. doi: 10.1097/IOP.0000000000000555. PMID: 26359698
Basal cell carcinoma.
Lear JT, Smith AG
Postgrad Med J 1997 Sep;73(863):538-42. doi: 10.1136/pgmj.73.863.538. PMID: 9373591Free PMC Article
Basal cell and squamous cell carcinomas. Clinico-histological features.
Annessi G, Baliva G
Ann Ist Super Sanita 1996;32(1):29-36. PMID: 8804183

Diagnosis

Use of preoperative and perioperative ex vivo dermoscopy for precise mapping of margins for standard surgical excision of primary basal cell carcinoma.
Savant SS Jr
Indian J Dermatol Venereol Leprol 2023 Sep-Oct;89(5):793. doi: 10.25259/IJDVL_325_2022. PMID: 37317762
Langerhans Cell Histiocytosis Presenting as a Nodulo-Ulcerative Eyelid Lesion.
Lo C, Patel P, Charles NC
Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3S Suppl 1):S51-S52. doi: 10.1097/IOP.0000000000000555. PMID: 26359698
Oral and maxillofacial pathology. Case of the month. Basal cell carcinoma, nodular (nodulo-ulcerative) type.
Havard D, Cheng YS, Ellis M
Tex Dent J 2012 Nov;129(11):1212-3, 1226-7. PMID: 23487893
Lower extremity malignancies masquerading as ulcers.
Perrotto J, Glick B
Ostomy Wound Manage 2006 Oct;52(10):46-52. PMID: 17041254
Basal cell carcinoma.
Lear JT, Smith AG
Postgrad Med J 1997 Sep;73(863):538-42. doi: 10.1136/pgmj.73.863.538. PMID: 9373591Free PMC Article

Therapy

Basal cell carcinoma.
Lear JT, Smith AG
Postgrad Med J 1997 Sep;73(863):538-42. doi: 10.1136/pgmj.73.863.538. PMID: 9373591Free PMC Article
Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?
Wolf P, Rieger E, Kerl H
J Am Acad Dermatol 1993 Jan;28(1):17-21. doi: 10.1016/0190-9622(93)70002-b. PMID: 8318069

Prognosis

Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?
Wolf P, Rieger E, Kerl H
J Am Acad Dermatol 1993 Jan;28(1):17-21. doi: 10.1016/0190-9622(93)70002-b. PMID: 8318069

Clinical prediction guides

Use of preoperative and perioperative ex vivo dermoscopy for precise mapping of margins for standard surgical excision of primary basal cell carcinoma.
Savant SS Jr
Indian J Dermatol Venereol Leprol 2023 Sep-Oct;89(5):793. doi: 10.25259/IJDVL_325_2022. PMID: 37317762
Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?
Wolf P, Rieger E, Kerl H
J Am Acad Dermatol 1993 Jan;28(1):17-21. doi: 10.1016/0190-9622(93)70002-b. PMID: 8318069
Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing.
Wolf C, Chenard MP, Durand de Grossouvre P, Bellocq JP, Chambon P, Basset P
J Invest Dermatol 1992 Dec;99(6):870-2. doi: 10.1111/1523-1747.ep12614846. PMID: 1469302
Fibronectin gene expression by epithelial tumor cells in basal cell carcinoma: an immunocytochemical and in situ hybridization study.
Peltonen J, Jaakkola S, Lask G, Virtanen I, Uitto J
J Invest Dermatol 1988 Oct;91(4):289-93. doi: 10.1111/1523-1747.ep12475415. PMID: 2459257

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