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Type I atherosclerotic lesion

MedGen UID:
1635748
•Concept ID:
C4703474
•
Disease or Syndrome
HPO: HP:0031679

Definition

Type I lesions represent the very initial changes and are recognized as an increase in the number of intimal macrophages and the appearance of macrophages filled with lipid droplets (foam cells). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType I atherosclerotic lesion

Professional guidelines

PubMed

Tolerogenic vaccines for the treatment of cardiovascular diseases.
Vigario FL, Kuiper J, Slütter B
EBioMedicine 2020 Jul;57:102827. Epub 2020 Jun 20 doi: 10.1016/j.ebiom.2020.102827. PMID: 32574952Free PMC Article
Low-density lipoprotein cholesterol lowering treatment: the current approach.
Crismaru I, Pantea Stoian A, Bratu OG, Gaman MA, Stanescu AMA, Bacalbasa N, Diaconu CC
Lipids Health Dis 2020 May 6;19(1):85. doi: 10.1186/s12944-020-01275-x. PMID: 32375792Free PMC Article
Newly approved devices for endovascular treatment of femoropopliteal disease: a review of clinical evidence.
Giannopoulos S, Armstrong EJ
Expert Rev Cardiovasc Ther 2019 Oct;17(10):729-740. Epub 2019 Oct 28 doi: 10.1080/14779072.2019.1675512. PMID: 31575289

Recent clinical studies

Etiology

Inflammation and the pathogenesis of atherosclerosis.
Libby P
Vascul Pharmacol 2024 Mar;154:107255. Epub 2023 Dec 28 doi: 10.1016/j.vph.2023.107255. PMID: 38157682
The immunology of atherosclerosis.
Gisterå A, Hansson GK
Nat Rev Nephrol 2017 Jun;13(6):368-380. Epub 2017 Apr 10 doi: 10.1038/nrneph.2017.51. PMID: 28392564
Lipoprotein(a) in cardiovascular diseases.
Malaguarnera M, Vacante M, Russo C, Malaguarnera G, Antic T, Malaguarnera L, Bella R, Pennisi G, Galvano F, Frigiola A
Biomed Res Int 2013;2013:650989. Epub 2012 Dec 30 doi: 10.1155/2013/650989. PMID: 23484137Free PMC Article
Diabetic dyslipidemia.
Kreisberg RA
Am J Cardiol 1998 Dec 17;82(12A):67U-73U; discussion 85U-86U. doi: 10.1016/s0002-9149(98)00848-0. PMID: 9915665
Endothelium and arteriosclerosis.
Harker LA, Schwartz SM, Ross R
Clin Haematol 1981 Jun;10(2):283-96. PMID: 7032778

Diagnosis

Lipid-lowering Therapy and Coronary Plaque Regression.
Ueki Y, Itagaki T, Kuwahara K
J Atheroscler Thromb 2024 Nov 1;31(11):1479-1495. Epub 2024 Aug 8 doi: 10.5551/jat.RV22024. PMID: 39111840Free PMC Article
Targeting Macrophages in Atherosclerosis.
Hu D, Wang Z, Wang Y, Liang C
Curr Pharm Biotechnol 2021;22(15):2008-2018. doi: 10.2174/1389201022666210122142233. PMID: 33480337
CXCL4-induced macrophages in human atherosclerosis.
Domschke G, Gleissner CA
Cytokine 2019 Oct;122:154141. Epub 2017 Sep 10 doi: 10.1016/j.cyto.2017.08.021. PMID: 28899579
Endovascular revascularization for aortoiliac atherosclerotic disease.
Aggarwal V, Waldo SW, Armstrong EJ
Vasc Health Risk Manag 2016;12:117-27. Epub 2016 Mar 29 doi: 10.2147/VHRM.S98721. PMID: 27099509Free PMC Article
Fibromuscular dysplasia.
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article

Therapy

Lipid-lowering Therapy and Coronary Plaque Regression.
Ueki Y, Itagaki T, Kuwahara K
J Atheroscler Thromb 2024 Nov 1;31(11):1479-1495. Epub 2024 Aug 8 doi: 10.5551/jat.RV22024. PMID: 39111840Free PMC Article
Drug intervention as an emerging concept for secondary prevention in patients with coronary disease.
Minami Y, Ako J, Tsujita K, Yokoi H, Ikari Y, Morino Y, Kobayashi Y, Kozuma K
Cardiovasc Interv Ther 2024 Jul;39(3):223-233. Epub 2024 Apr 8 doi: 10.1007/s12928-024-00994-7. PMID: 38587750
Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial.
Räber L, Ueki Y, Otsuka T, Losdat S, Häner JD, Lonborg J, Fahrni G, Iglesias JF, van Geuns RJ, Ondracek AS, Radu Juul Jensen MD, Zanchin C, Stortecky S, Spirk D, Siontis GCM, Saleh L, Matter CM, Daemen J, Mach F, Heg D, Windecker S, Engstrøm T, Lang IM, Koskinas KC; PACMAN-AMI collaborators
JAMA 2022 May 10;327(18):1771-1781. doi: 10.1001/jama.2022.5218. PMID: 35368058Free PMC Article
Targeting Macrophages in Atherosclerosis.
Hu D, Wang Z, Wang Y, Liang C
Curr Pharm Biotechnol 2021;22(15):2008-2018. doi: 10.2174/1389201022666210122142233. PMID: 33480337
Fibromuscular dysplasia.
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article

Prognosis

Inflammation and the pathogenesis of atherosclerosis.
Libby P
Vascul Pharmacol 2024 Mar;154:107255. Epub 2023 Dec 28 doi: 10.1016/j.vph.2023.107255. PMID: 38157682
Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.
Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D
Circ Res 2018 Jun 8;122(12):1675-1688. Epub 2018 Mar 15 doi: 10.1161/CIRCRESAHA.117.312513. PMID: 29545366Free PMC Article
Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article
Fibromuscular dysplasia.
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article
Diabetic dyslipidemia.
Kreisberg RA
Am J Cardiol 1998 Dec 17;82(12A):67U-73U; discussion 85U-86U. doi: 10.1016/s0002-9149(98)00848-0. PMID: 9915665

Clinical prediction guides

Inflammation and the pathogenesis of atherosclerosis.
Libby P
Vascul Pharmacol 2024 Mar;154:107255. Epub 2023 Dec 28 doi: 10.1016/j.vph.2023.107255. PMID: 38157682
Same-Day Discharge After Elective Percutaneous Transcatheter Cardiovascular Interventions.
Krishnaswamy A, Isogai T, Brilakis ES, Nanjundappa A, Ziada KM, Parikh SA, Rodés-Cabau J, Windecker S, Kapadia SR
JACC Cardiovasc Interv 2023 Jul 10;16(13):1561-1578. doi: 10.1016/j.jcin.2023.05.015. PMID: 37438024
Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.
Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D
Circ Res 2018 Jun 8;122(12):1675-1688. Epub 2018 Mar 15 doi: 10.1161/CIRCRESAHA.117.312513. PMID: 29545366Free PMC Article
Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article
Fibromuscular dysplasia.
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article

Recent systematic reviews

Chronic pancreatitis and the heart disease: Still terra incognita?
Nikolic S, Dugic A, Steiner C, Tsolakis AV, Haugen Löfman IM, Löhr JM, Vujasinovic M
World J Gastroenterol 2019 Nov 28;25(44):6561-6570. doi: 10.3748/wjg.v25.i44.6561. PMID: 31802835Free PMC Article
Diagnostic methods for measurement of peripheral blood flow during exercise in patients with type 2 diabetes and peripheral artery disease: a systematic review.
Eiken FL, Pedersen BL, Bækgaard N, Eiberg JP
Int Angiol 2019 Feb;38(1):62-69. doi: 10.23736/S0392-9590.18.04051-8. PMID: 30860342
Fibromuscular Dysplasia and Its Neurologic Manifestations: A Systematic Review.
Touzé E, Southerland AM, Boulanger M, Labeyrie PE, Azizi M, Bouatia-Naji N, Debette S, Gornik HL, Hussain SM, Jeunemaitre X, Joux J, Kirton A, Le Hello C, Majersik JJ, Mocco J, Persu A, Sharma A, Worrall BB, Olin JW, Plouin PF
JAMA Neurol 2019 Feb 1;76(2):217-226. doi: 10.1001/jamaneurol.2018.2848. PMID: 30285053
Interventions to Reduce Cardiovascular Risk in Children with Type 1 Diabetes.
Canas JA, Gidding SS, Mauras N
Curr Diabetes Rev 2017;13(6):544-554. doi: 10.2174/1573399813666170113142621. PMID: 28088892
Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for peripheral arterial disease of the lower limbs.
Kayssi A, Al-Atassi T, Oreopoulos G, Roche-Nagle G, Tan KT, Rajan DK
Cochrane Database Syst Rev 2016 Aug 4;2016(8):CD011319. doi: 10.1002/14651858.CD011319.pub2. PMID: 27490003Free PMC Article

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