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Progressive Medulloblastoma

MedGen UID:
1632224
•Concept ID:
C4687711
•
Neoplastic Process

Definition

Medulloblastoma that is increasing in scope or severity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProgressive Medulloblastoma

Professional guidelines

PubMed

Results of radiosurgery in the management of recurrent and residual medulloblastoma.
Patrice SJ, Tarbell NJ, Goumnerova LC, Shrieve DC, Black PM, Loeffler JS
Pediatr Neurosurg 1995;22(4):197-203. doi: 10.1159/000120901. PMID: 7619720

Recent clinical studies

Etiology

Life-threatening altered mental status secondary to memantine in an adolescent undergoing cranial radiotherapy for medulloblastoma.
Kim KN, Shah YB, Croy C, Lustig RA, LaRiviere M, Kotch C
J Oncol Pharm Pract 2023 Mar;29(2):469-472. Epub 2022 May 23 doi: 10.1177/10781552221102883. PMID: 35607285
Outcomes of salvage re-irradiation in recurrent medulloblastoma correlate with age at initial diagnosis, primary risk-stratification, and molecular subgrouping.
Gupta T, Maitre M, Sastri GJ, Krishnatry R, Shirsat N, Epari S, Sahay A, Chinnaswamy G, Patil V, Shetty P, Moiyadi A
J Neurooncol 2019 Sep;144(2):283-291. Epub 2019 Jun 24 doi: 10.1007/s11060-019-03225-9. PMID: 31236820
Survival After Relapse of Medulloblastoma.
Koschmann C, Bloom K, Upadhyaya S, Geyer JR, Leary SE
J Pediatr Hematol Oncol 2016 May;38(4):269-73. doi: 10.1097/MPH.0000000000000547. PMID: 26907655
Impact of site of tumor recurrence upon survival for children with recurrent or progressive medulloblastoma.
Bowers DC, Gargan L, Weprin BE, Mulne AF, Elterman RD, Munoz L, Giller CA, Winick NJ
J Neurosurg 2007 Jul;107(1 Suppl):5-10. doi: 10.3171/PED-07/07/005. PMID: 17644914
Results of radiosurgery in the management of recurrent and residual medulloblastoma.
Patrice SJ, Tarbell NJ, Goumnerova LC, Shrieve DC, Black PM, Loeffler JS
Pediatr Neurosurg 1995;22(4):197-203. doi: 10.1159/000120901. PMID: 7619720

Diagnosis

Outcomes of salvage re-irradiation in recurrent medulloblastoma correlate with age at initial diagnosis, primary risk-stratification, and molecular subgrouping.
Gupta T, Maitre M, Sastri GJ, Krishnatry R, Shirsat N, Epari S, Sahay A, Chinnaswamy G, Patil V, Shetty P, Moiyadi A
J Neurooncol 2019 Sep;144(2):283-291. Epub 2019 Jun 24 doi: 10.1007/s11060-019-03225-9. PMID: 31236820
Survival After Relapse of Medulloblastoma.
Koschmann C, Bloom K, Upadhyaya S, Geyer JR, Leary SE
J Pediatr Hematol Oncol 2016 May;38(4):269-73. doi: 10.1097/MPH.0000000000000547. PMID: 26907655
Impact of site of tumor recurrence upon survival for children with recurrent or progressive medulloblastoma.
Bowers DC, Gargan L, Weprin BE, Mulne AF, Elterman RD, Munoz L, Giller CA, Winick NJ
J Neurosurg 2007 Jul;107(1 Suppl):5-10. doi: 10.3171/PED-07/07/005. PMID: 17644914
Results of radiosurgery in the management of recurrent and residual medulloblastoma.
Patrice SJ, Tarbell NJ, Goumnerova LC, Shrieve DC, Black PM, Loeffler JS
Pediatr Neurosurg 1995;22(4):197-203. doi: 10.1159/000120901. PMID: 7619720
Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy.
Gajjar A, Mulhern RK, Heideman RL, Sanford RA, Douglass EC, Kovnar EH, Langston JA, Jenkins JJ, Kun LE
J Clin Oncol 1994 Jun;12(6):1212-6. doi: 10.1200/JCO.1994.12.6.1212. PMID: 8201384

Therapy

Life-threatening altered mental status secondary to memantine in an adolescent undergoing cranial radiotherapy for medulloblastoma.
Kim KN, Shah YB, Croy C, Lustig RA, LaRiviere M, Kotch C
J Oncol Pharm Pract 2023 Mar;29(2):469-472. Epub 2022 May 23 doi: 10.1177/10781552221102883. PMID: 35607285
Phase I study of temozolomide combined with oral etoposide in children with recurrent or progressive medulloblastoma.
Ruggiero A, Rizzo D, Attinà G, Lazzareschi I, Mastrangelo S, Maurizi P, Migliorati R, Bertolini P, Pastore M, Colosimo C, Riccardi R
Eur J Cancer 2010 Nov;46(16):2943-9. Epub 2010 Jun 9 doi: 10.1016/j.ejca.2010.05.016. PMID: 20538454
Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy.
Gajjar A, Mulhern RK, Heideman RL, Sanford RA, Douglass EC, Kovnar EH, Langston JA, Jenkins JJ, Kun LE
J Clin Oncol 1994 Jun;12(6):1212-6. doi: 10.1200/JCO.1994.12.6.1212. PMID: 8201384

Prognosis

Outcomes of salvage re-irradiation in recurrent medulloblastoma correlate with age at initial diagnosis, primary risk-stratification, and molecular subgrouping.
Gupta T, Maitre M, Sastri GJ, Krishnatry R, Shirsat N, Epari S, Sahay A, Chinnaswamy G, Patil V, Shetty P, Moiyadi A
J Neurooncol 2019 Sep;144(2):283-291. Epub 2019 Jun 24 doi: 10.1007/s11060-019-03225-9. PMID: 31236820
Survival After Relapse of Medulloblastoma.
Koschmann C, Bloom K, Upadhyaya S, Geyer JR, Leary SE
J Pediatr Hematol Oncol 2016 May;38(4):269-73. doi: 10.1097/MPH.0000000000000547. PMID: 26907655
Phase I study of temozolomide combined with oral etoposide in children with recurrent or progressive medulloblastoma.
Ruggiero A, Rizzo D, Attinà G, Lazzareschi I, Mastrangelo S, Maurizi P, Migliorati R, Bertolini P, Pastore M, Colosimo C, Riccardi R
Eur J Cancer 2010 Nov;46(16):2943-9. Epub 2010 Jun 9 doi: 10.1016/j.ejca.2010.05.016. PMID: 20538454
Impact of site of tumor recurrence upon survival for children with recurrent or progressive medulloblastoma.
Bowers DC, Gargan L, Weprin BE, Mulne AF, Elterman RD, Munoz L, Giller CA, Winick NJ
J Neurosurg 2007 Jul;107(1 Suppl):5-10. doi: 10.3171/PED-07/07/005. PMID: 17644914
Results of radiosurgery in the management of recurrent and residual medulloblastoma.
Patrice SJ, Tarbell NJ, Goumnerova LC, Shrieve DC, Black PM, Loeffler JS
Pediatr Neurosurg 1995;22(4):197-203. doi: 10.1159/000120901. PMID: 7619720

Clinical prediction guides

Phase I study of temozolomide combined with oral etoposide in children with recurrent or progressive medulloblastoma.
Ruggiero A, Rizzo D, Attinà G, Lazzareschi I, Mastrangelo S, Maurizi P, Migliorati R, Bertolini P, Pastore M, Colosimo C, Riccardi R
Eur J Cancer 2010 Nov;46(16):2943-9. Epub 2010 Jun 9 doi: 10.1016/j.ejca.2010.05.016. PMID: 20538454
Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy.
Gajjar A, Mulhern RK, Heideman RL, Sanford RA, Douglass EC, Kovnar EH, Langston JA, Jenkins JJ, Kun LE
J Clin Oncol 1994 Jun;12(6):1212-6. doi: 10.1200/JCO.1994.12.6.1212. PMID: 8201384

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