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Hormone-resistant breast carcinoma

MedGen UID:
1631521
•Concept ID:
C4049259
•
Neoplastic Process
Synonyms: Hormone-Refractory Breast Cancer; hormone-refractory breast cancer; Hormone-Resistant Breast Adenocarcinoma; Hormone-Resistant Breast Cancer; hormone-resistant breast cancer; Hormone-Resistant Breast Carcinoma; hormone-resistant breast carcinoma
 
Monarch Initiative: MONDO:0056813

Definition

Breast adenocarcinoma that does not respond to hormone therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHormone-resistant breast carcinoma

Professional guidelines

PubMed

Cholesterol biogenesis is a PTEN-dependent actionable node for the treatment of endocrine therapy-refractory cancers.
Kaysudu I, Gungul TB, Atici S, Yilmaz S, Bayram E, Guven G, Cizmecioglu NT, Sahin O, Yesiloz G, Haznedaroglu BZ, Cizmecioglu O
Cancer Sci 2023 Nov;114(11):4365-4375. Epub 2023 Sep 14 doi: 10.1111/cas.15960. PMID: 37706278Free PMC Article
Clinical efficacy and prospects for use of pegylated liposomal doxorubicin in the treatment of ovarian and breast cancers.
Muggia FM
Drugs 1997;54 Suppl 4:22-9. doi: 10.2165/00003495-199700544-00006. PMID: 9361958
Management of breast cancer: status and future trends.
Hortobagyi GN
Semin Oncol 1995 Oct;22(5 Suppl 12):101-7. PMID: 7481851

Recent clinical studies

Etiology

Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.
Militaru FC, Militaru V, Crisan N, Bocsan IC, Udrea AA, Catana A, Kutasi E, Militaru MS
Biomol Biomed 2023 Sep 4;23(5):760-771. doi: 10.17305/bb.2023.8782. PMID: 37021836Free PMC Article
Leptin Signaling Contributes to Aromatase Inhibitor Resistant Breast Cancer Cell Growth and Activation of Macrophages.
Gelsomino L, Giordano C, Camera G, Sisci D, Marsico S, Campana A, Tarallo R, Rinaldi A, Fuqua S, Leggio A, Grande F, Bonofiglio D, Andò S, Barone I, Catalano S
Biomolecules 2020 Apr 3;10(4) doi: 10.3390/biom10040543. PMID: 32260113Free PMC Article
Gefitinib treatment in hormone-resistant and hormone receptor-negative advanced breast cancer.
Green MD, Francis PA, Gebski V, Harvey V, Karapetis C, Chan A, Snyder R, Fong A, Basser R, Forbes JF; Australian New Zealand Breast Cancer Trials Group
Ann Oncol 2009 Nov;20(11):1813-7. Epub 2009 Jun 24 doi: 10.1093/annonc/mdp202. PMID: 19553291
Cytotoxic chemotherapy for prostate cancer: Who and when?
Moss RA, Petrylak DP
Curr Treat Options Oncol 2006 Sep;7(5):370-7. doi: 10.1007/s11864-006-0005-x. PMID: 16904054
Male breast cancer.
Volm MD
Curr Treat Options Oncol 2003 Apr;4(2):159-64. doi: 10.1007/s11864-003-0017-8. PMID: 12594942

Diagnosis

Cholesterol biogenesis is a PTEN-dependent actionable node for the treatment of endocrine therapy-refractory cancers.
Kaysudu I, Gungul TB, Atici S, Yilmaz S, Bayram E, Guven G, Cizmecioglu NT, Sahin O, Yesiloz G, Haznedaroglu BZ, Cizmecioglu O
Cancer Sci 2023 Nov;114(11):4365-4375. Epub 2023 Sep 14 doi: 10.1111/cas.15960. PMID: 37706278Free PMC Article
Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.
Militaru FC, Militaru V, Crisan N, Bocsan IC, Udrea AA, Catana A, Kutasi E, Militaru MS
Biomol Biomed 2023 Sep 4;23(5):760-771. doi: 10.17305/bb.2023.8782. PMID: 37021836Free PMC Article
Combination of molecular-targeted drugs with endocrine therapy for hormone-resistant breast cancer.
Saji S, Kimura-Tsuchiya R
Int J Clin Oncol 2015 Apr;20(2):268-72. Epub 2015 Feb 24 doi: 10.1007/s10147-015-0799-2. PMID: 25708592
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer.
Toy W, Shen Y, Won H, Green B, Sakr RA, Will M, Li Z, Gala K, Fanning S, King TA, Hudis C, Chen D, Taran T, Hortobagyi G, Greene G, Berger M, Baselga J, Chandarlapaty S
Nat Genet 2013 Dec;45(12):1439-45. Epub 2013 Nov 3 doi: 10.1038/ng.2822. PMID: 24185512Free PMC Article

Therapy

Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.
Militaru FC, Militaru V, Crisan N, Bocsan IC, Udrea AA, Catana A, Kutasi E, Militaru MS
Biomol Biomed 2023 Sep 4;23(5):760-771. doi: 10.17305/bb.2023.8782. PMID: 37021836Free PMC Article
Development and characterization of a patient‑derived orthotopic xenograft of therapy‑resistant breast cancer.
Butti R, Kapse P, Bhadauriya G, Ahmad S, Chaubal R, Parab P, Kadam R, Mahapatra SS, Shet T, Dutt A, Gupta S, Kundu GC
Oncol Rep 2023 May;49(5) Epub 2023 Mar 31 doi: 10.3892/or.2023.8536. PMID: 36999625Free PMC Article
Combination of molecular-targeted drugs with endocrine therapy for hormone-resistant breast cancer.
Saji S, Kimura-Tsuchiya R
Int J Clin Oncol 2015 Apr;20(2):268-72. Epub 2015 Feb 24 doi: 10.1007/s10147-015-0799-2. PMID: 25708592
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer.
Toy W, Shen Y, Won H, Green B, Sakr RA, Will M, Li Z, Gala K, Fanning S, King TA, Hudis C, Chen D, Taran T, Hortobagyi G, Greene G, Berger M, Baselga J, Chandarlapaty S
Nat Genet 2013 Dec;45(12):1439-45. Epub 2013 Nov 3 doi: 10.1038/ng.2822. PMID: 24185512Free PMC Article

Prognosis

Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.
Militaru FC, Militaru V, Crisan N, Bocsan IC, Udrea AA, Catana A, Kutasi E, Militaru MS
Biomol Biomed 2023 Sep 4;23(5):760-771. doi: 10.17305/bb.2023.8782. PMID: 37021836Free PMC Article
The Role of ESRP1 in the Regulation of PHGDH in Estrogen Receptor-Positive Breast Cancer.
Gökmen-Polar Y, Gu Y, Polar A, Gu X, Badve SS
Lab Invest 2023 Mar;103(3):100002. Epub 2023 Jan 10 doi: 10.1016/j.labinv.2022.100002. PMID: 36925195
Correlations of DKK1 with incidence and prognosis of breast cancer.
Sun W, Shang J, Zhang J, Chen S, Hao M
J BUON 2019 Jan-Feb;24(1):26-32. PMID: 30941948
Cytotoxic chemotherapy for prostate cancer: Who and when?
Moss RA, Petrylak DP
Curr Treat Options Oncol 2006 Sep;7(5):370-7. doi: 10.1007/s11864-006-0005-x. PMID: 16904054
Chemotherapy of breast cancer: a historical perspective.
Hortobagyi GN
Semin Oncol 1997 Oct;24(5 Suppl 17):S17-1-S17-4. PMID: 9374083

Clinical prediction guides

Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers.
Singh K, Munuganti RSN, Lallous N, Dalal K, Yoon JS, Sharma A, Yamazaki T, Cherkasov A, Rennie PS
Int J Mol Sci 2018 Feb 15;19(2) doi: 10.3390/ijms19020579. PMID: 29462880Free PMC Article
Selecting endocrine therapy for breast cancer: what role does HER-2/neu status play?
Prowell TM, Armstrong DK
Semin Oncol 2006 Dec;33(6):681-7. doi: 10.1053/j.seminoncol.2006.08.016. PMID: 17145348
Chemotherapy of breast cancer: a historical perspective.
Hortobagyi GN
Semin Oncol 1997 Oct;24(5 Suppl 17):S17-1-S17-4. PMID: 9374083
Can hormone "resistant" breast cancer cells be inappropriately stimulated by tamoxifen?
Horwitz KB
Ann N Y Acad Sci 1993 Jun 11;684:63-74. doi: 10.1111/j.1749-6632.1993.tb32271.x. PMID: 8317847

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